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Shen L, Dien Bard J, Biegel JA, et al. Comprehensive Genome Analysis of 6,000 USA SARS-CoV-2 Isolates Reveals Haplotype Signatures and Localized Transmission Patterns by State and by Country. Front Microbiol. 2020;11:573430doi: 10.3389/fmicb.2020.573430.
Shen, L., Dien Bard, J., Biegel, J. A., Judkins, A. R., & Gai, X. (2020). Comprehensive Genome Analysis of 6,000 USA SARS-CoV-2 Isolates Reveals Haplotype Signatures and Localized Transmission Patterns by State and by Country. Frontiers in microbiology, 11573430. https://doi.org/10.3389/fmicb.2020.573430
Shen, Lishuang, et al. "Comprehensive Genome Analysis of 6,000 USA SARS-CoV-2 Isolates Reveals Haplotype Signatures and Localized Transmission Patterns by State and by Country." Frontiers in microbiology vol. 11 (2020): 573430. doi: https://doi.org/10.3389/fmicb.2020.573430
Shen L, Dien Bard J, Biegel JA, Judkins AR, Gai X. Comprehensive Genome Analysis of 6,000 USA SARS-CoV-2 Isolates Reveals Haplotype Signatures and Localized Transmission Patterns by State and by Country. Front Microbiol. 2020 Sep 03;11:573430. doi: 10.3389/fmicb.2020.573430. eCollection 2020. PMID: 33013809; PMCID: PMC7509426.
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Front Microbiol. 2020 Sep 03;11:573430. doi: 10.3389/fmicb.2020.573430. eCollection 2020.

Comprehensive Genome Analysis of 6,000 USA SARS-CoV-2 Isolates Reveals Haplotype Signatures and Localized Transmission Patterns by State and by Country.

Frontiers in microbiology

Lishuang Shen, Jennifer Dien Bard, Jaclyn A Biegel, Alexander R Judkins, Xiaowu Gai

Affiliations

  1. Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, United States.
  2. Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.

PMID: 33013809 PMCID: PMC7509426 DOI: 10.3389/fmicb.2020.573430

Abstract

Genomic analysis of SARS-CoV-2 sequences is crucial in determining the effectiveness of prudent safer at home measures in the United States (US). By haplotype analysis of 6,356 US isolates, we identified a pattern of strongly localized outbreaks at the city-, state-, and country-levels, and temporal transmissions. This points to the effectiveness of existing travel restriction policies and public health measures in reducing the transmission of SARS-CoV-2.

Copyright © 2020 Shen, Dien Bard, Biegel, Judkins and Gai.

Keywords: COVID-19; SARS-CoV-2; haplotype; localized outbreak; temporal transmission; variant

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