Fatigue. 2019;7(4):196-206. doi: 10.1080/21641846.2019.1687117. Epub 2019 Nov 06.
Differentiating Post-Polio Syndrome from Myalgic Encephalomyelitis and Chronic Fatigue Syndrome.
Fatigue : biomedicine, health & behavior
Lauren Klebek, Madison Sunnquist, Leonard A Jason
Affiliations
Affiliations
- Center for Community Research, DePaul University.
PMID: 33014628
PMCID: PMC7531614 DOI: 10.1080/21641846.2019.1687117
Abstract
BACKGROUND: Overlapping and concomitant symptoms among similar chronic illnesses have created difficulties for diagnosis and further treatment. Three such chronically fatiguing illnesses, Post-polio syndrome (PPS), Myalgic Encephalomyelitis (ME) and chronic fatigue syndrome (CFS) fall under this category.
PURPOSE: The aim of this study is to examine and distinguish between core symptoms found in these illnesses (i.e. muscle pain/weakness, fatigue or exhaustion, and autonomic symptoms) via three methods of analysis (DePaul Symptom Questionnaire 2 (DSQ-2), Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36), and machine learning techniques).
RESULTS: Items assessing onset and severity for individuals who reported having PPS were found to have experienced an onset of PPS related symptoms roughly 30 years after the onset of Polio. Items found in the DSQ-2, SF-36 compared all illness groups and found that participants with ME/CFS were more functionally impaired across symptoms than those with PPS. Across all analyses, three domains most commonly differentiated the illnesses (neurocognitive, Post-exertional malaise, and neuroendocrine).
CONCLUSION: Examining functional impairment amongst chronically fatiguing illnesses using multiple methods of analysis can be an important factor in distinguishing similar illnesses. These findings support further analysis of analogous symptomatology among other chronic illnesses to assist in diagnosis.
Keywords: Myalgic Encephalomyelitis; chronic fatigue syndrome; chronic illness; fatigue; polio; post-polio syndrome
References
- J Biomed Inform. 2009 Apr;42(2):377-81 - PubMed
- Arch Phys Med Rehabil. 1991 Feb;72(2):115-8 - PubMed
- Med Care. 1994 Jan;32(1):40-66 - PubMed
- Am J Med. 1998 Sep 28;105(3A):66S-73S - PubMed
- Fatigue. 2015;3(3):164-172 - PubMed
- Popul Health Metr. 2007 Jun 08;5:5 - PubMed
- Neurology (ECronicon). 2016;4(2):41-45 - PubMed
- Crit Rev Neurobiol. 1987;3(3):199-220 - PubMed
- Fatigue. 2015 Jan 1;3(1):16-32 - PubMed
- Front Pediatr. 2018 Nov 06;6:330 - PubMed
- Med Care. 1992 Jun;30(6):473-83 - PubMed
- Am J Epidemiol. 1992 Oct 1;136(7):769-86 - PubMed
- Autoimmun Rev. 2018 Jun;17(6):601-609 - PubMed
- Qual Life Res. 2017 Apr;26(4):913-921 - PubMed
- Biomed Eng Online. 2004 Jun 29;3(1):21 - PubMed
- Arch Intern Med. 1999 Oct 11;159(18):2129-37 - PubMed
- Shanghai Arch Psychiatry. 2015 Apr 25;27(2):130-5 - PubMed
- Fatigue. 2014 Jan 1;2(1):40-56 - PubMed
- Autoimmun Rev. 2009 Feb;8(4):287-91 - PubMed
- Med Care Res Rev. 2006 Apr;63(2):217-35 - PubMed
- J Neurol Sci. 2005 Sep 15;236(1-2):31-5 - PubMed
- Spinal Cord. 1998 Apr;36(4):280-4 - PubMed
- Arch Phys Med Rehabil. 1994 Oct;75(10):1122-6 - PubMed
- Insights Biomed. 2017;2(2): - PubMed
- Ann Behav Med. 2003 Dec;26(3):172-81 - PubMed
- J Psychosom Res. 2002 Jun;52(6):467-73 - PubMed
- Fatigue. 2014;2(3):132-152 - PubMed
- Health Policy. 2005 Jan;71(1):97-106 - PubMed
- Fatigue. 2019;7(3):166-179 - PubMed
Publication Types
Grant support