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Cornelissen LAM, Blanas A, Zaal A, et al. Tn Antigen Expression Contributes to an Immune Suppressive Microenvironment and Drives Tumor Growth in Colorectal Cancer. Front Oncol. 2020;10:1622doi: 10.3389/fonc.2020.01622.
Cornelissen, L. A. M., Blanas, A., Zaal, A., van der Horst, J. C., Kruijssen, L. J. W., O'Toole, T., van Kooyk, Y., & van Vliet, S. J. (2020). Tn Antigen Expression Contributes to an Immune Suppressive Microenvironment and Drives Tumor Growth in Colorectal Cancer. Frontiers in oncology, 101622. https://doi.org/10.3389/fonc.2020.01622
Cornelissen, Lenneke A M, et al. "Tn Antigen Expression Contributes to an Immune Suppressive Microenvironment and Drives Tumor Growth in Colorectal Cancer." Frontiers in oncology vol. 10 (2020): 1622. doi: https://doi.org/10.3389/fonc.2020.01622
Cornelissen LAM, Blanas A, Zaal A, van der Horst JC, Kruijssen LJW, O'Toole T, van Kooyk Y, van Vliet SJ. Tn Antigen Expression Contributes to an Immune Suppressive Microenvironment and Drives Tumor Growth in Colorectal Cancer. Front Oncol. 2020 Aug 18;10:1622. doi: 10.3389/fonc.2020.01622. eCollection 2020. PMID: 33014816; PMCID: PMC7461972.
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Front Oncol. 2020 Aug 18;10:1622. doi: 10.3389/fonc.2020.01622. eCollection 2020.

Tn Antigen Expression Contributes to an Immune Suppressive Microenvironment and Drives Tumor Growth in Colorectal Cancer.

Frontiers in oncology

Lenneke A M Cornelissen, Athanasios Blanas, Anouk Zaal, Joost C van der Horst, Laura J W Kruijssen, Tom O'Toole, Yvette van Kooyk, Sandra J van Vliet

Affiliations

  1. Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection & Immunity Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

PMID: 33014816 PMCID: PMC7461972 DOI: 10.3389/fonc.2020.01622

Abstract

Expression of the tumor-associated glycan Tn antigen (αGalNAc-Ser/Thr) has been correlated to poor prognosis and metastasis in multiple cancer types. However, the exact mechanisms exerted by Tn antigen to support tumor growth are still lacking. One emerging hallmark of cancer is evasion of immune destruction. Although tumor cells often exploit the glycosylation machinery to interact with the immune system, the contribution of Tn antigen to an immunosuppressive tumor microenvironment has scarcely been studied. Here, we explored how Tn antigen influences the tumor immune cell composition in a colorectal cancer (CRC) mouse model. CRISPR/Cas9-mediated knock out of the

Copyright © 2020 Cornelissen, Blanas, Zaal, van der Horst, Kruijssen, O’Toole, van Kooyk and van Vliet.

Keywords: O-glycosylation; Tn antigen; anti-tumor immunity; colorectal cancer; tumor growth

References

  1. Biomolecules. 2016 May 03;6(2): - PubMed
  2. Clin Exp Metastasis. 2002;19(1):61-70 - PubMed
  3. Oncogene. 2018 Oct;37(43):5780-5793 - PubMed
  4. Int Immunol. 2005 May;17(5):661-9 - PubMed
  5. J Exp Med. 2012 Jan 16;209(1):109-21 - PubMed
  6. Glycobiology. 2013 Jul;23(7):844-52 - PubMed
  7. Cancer Res. 2006 Jan 15;66(2):1123-31 - PubMed
  8. Bioinformatics. 2014 Apr 1;30(7):923-30 - PubMed
  9. Bioinformatics. 2009 Apr 15;25(8):1091-3 - PubMed
  10. Mol Immunol. 2009 Mar;46(6):1240-9 - PubMed
  11. Nat Med. 2015 Nov;21(11):1350-6 - PubMed
  12. J Cell Biol. 2004 Feb 2;164(3):451-9 - PubMed
  13. J Cell Mol Med. 2019 Mar;23(3):2083-2092 - PubMed
  14. Lancet. 2018 May 26;391(10135):2128-2139 - PubMed
  15. Nucleic Acids Res. 2012 May;40(10):4288-97 - PubMed
  16. Oncotarget. 2015 Sep 22;6(28):26278-90 - PubMed
  17. Cancer Res. 1989 Jan 1;49(1):197-204 - PubMed
  18. Clin Cancer Res. 2018 Sep 15;24(18):4468-4481 - PubMed
  19. Nat Immunol. 2016 Nov;17(11):1273-1281 - PubMed
  20. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3152-61 - PubMed
  21. Cancer Res. 2010 Jan 1;70(1):99-108 - PubMed
  22. Glycobiology. 2012 Jun;22(6):736-56 - PubMed
  23. J Exp Med. 2007 Jun 11;204(6):1417-29 - PubMed
  24. Nat Rev Immunol. 2009 Mar;9(3):162-74 - PubMed
  25. Immunol Lett. 1993 Jun;36(3):239-43 - PubMed
  26. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4066-75 - PubMed
  27. Cancer Manag Res. 2020 Jan 22;12:511-522 - PubMed
  28. Trends Immunol. 2018 Jul;39(7):523-535 - PubMed
  29. Methods Enzymol. 2010;479:123-41 - PubMed
  30. Front Oncol. 2019 Jan 29;9:29 - PubMed
  31. Int J Mol Sci. 2016 Feb 24;17(3):275 - PubMed
  32. PLoS One. 2017 Jul 18;12(7):e0179241 - PubMed
  33. Mol Cancer. 2015 May 29;14:109 - PubMed
  34. PLoS One. 2015 May 07;10(5):e0125994 - PubMed
  35. Front Immunol. 2020 Feb 25;11:305 - PubMed
  36. Cell Signal. 2012 Mar;24(3):718-25 - PubMed
  37. Genome Res. 2003 Nov;13(11):2498-504 - PubMed
  38. J Exp Med. 2020 Jan 6;217(1): - PubMed
  39. Bioinformatics. 2010 Jan 1;26(1):139-40 - PubMed
  40. BMC Cancer. 2018 Aug 16;18(1):827 - PubMed
  41. Nat Rev Immunol. 2018 Mar;18(3):204-211 - PubMed
  42. Oncotarget. 2015 Mar 20;6(8):6123-35 - PubMed
  43. PLoS One. 2013 Sep 06;8(9):e72413 - PubMed
  44. Semin Cancer Biol. 2020 Feb;60:41-56 - PubMed
  45. Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4572-7 - PubMed
  46. Br J Cancer. 2013 Jul 9;109(1):138-46 - PubMed
  47. Nat Rev Cancer. 2012 Mar 15;12(4):298-306 - PubMed
  48. Nat Rev Cancer. 2015 Sep;15(9):540-55 - PubMed
  49. Nat Immunol. 2006 Nov;7(11):1200-8 - PubMed
  50. Cancer Immunol Immunother. 2007 Aug;56(8):1225-36 - PubMed
  51. J Leukoc Biol. 2013 Aug;94(2):315-23 - PubMed
  52. J Biol Chem. 2015 Aug 14;290(33):20159-66 - PubMed
  53. Curr Opin Immunol. 2018 Apr;51:123-132 - PubMed
  54. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9228-33 - PubMed
  55. Nat Immunol. 2018 Feb;19(2):108-119 - PubMed
  56. Nat Methods. 2015 Apr;12(4):357-60 - PubMed
  57. Nat Rev Immunol. 2002 Feb;2(2):77-84 - PubMed
  58. BJS Open. 2018 Apr 27;2(5):353-359 - PubMed
  59. Bioinformatics. 2009 Aug 15;25(16):2078-9 - PubMed
  60. Nat Protoc. 2013 Nov;8(11):2281-2308 - PubMed
  61. Biomed Res Int. 2018 Jun 21;2018:9532389 - PubMed
  62. J Cell Mol Med. 2018 Oct;22(10):4875-4885 - PubMed
  63. Am J Pathol. 2002 Mar;160(3):1001-8 - PubMed
  64. Front Immunol. 2018 Dec 20;9:3059 - PubMed
  65. Methods Mol Biol. 2013;1022:15-28 - PubMed
  66. Immunobiology. 2006;211(6-8):577-85 - PubMed
  67. Int J Cancer. 2019 May 1;144(9):2290-2302 - PubMed

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