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Ardeshir F, Keshavarz L, Asadian F, et al. Role of the 820 A/G variant in the . Int J Reprod Biomed. 2020;18(9):747-754doi: 10.18502/ijrm.v13i9.7669.
Ardeshir, F., Keshavarz, L., Asadian, F., Omidmokhtarkhanloo, G., & Yavarian, M. (2020). Role of the 820 A/G variant in the . International journal of reproductive biomedicine, 18(9), 747-754. https://doi.org/10.18502/ijrm.v13i9.7669
Ardeshir, Farzaneh, et al. "Role of the 820 A/G variant in the ." International journal of reproductive biomedicine vol. 18,9 (2020): 747-754. doi: https://doi.org/10.18502/ijrm.v13i9.7669
Ardeshir F, Keshavarz L, Asadian F, Omidmokhtarkhanloo G, Yavarian M. Role of the 820 A/G variant in the . Int J Reprod Biomed. 2020 Sep 20;18(9):747-754. doi: 10.18502/ijrm.v13i9.7669. eCollection 2020 Sep. PMID: 33062920; PMCID: PMC7521167.
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Int J Reprod Biomed. 2020 Sep 20;18(9):747-754. doi: 10.18502/ijrm.v13i9.7669. eCollection 2020 Sep.

Role of the 820 A/G variant in the .

International journal of reproductive biomedicine

Farzaneh Ardeshir, Leila Keshavarz, Fatemeh Asadian, Gohar Omidmokhtarkhanloo, Majid Yavarian

Affiliations

  1. Department of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran.
  2. Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran.
  3. Persian Bayan Gene Research and Training Center, Dr. Faghihi's Medical Genetic Center, Siraz, Iran.
  4. Shiraz Nephron-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

PMID: 33062920 PMCID: PMC7521167 DOI: 10.18502/ijrm.v13i9.7669

Abstract

BACKGROUND: Insulin-like growth factor-2 (

OBJECTIVE: This cross-sectional study aimed to investigate the role of 820A/G variant of the

MATERIALS AND METHODS: In this study, 50 aborted fetuses tissue for the study group and blood samples umbilical-cord from newborns as control group (n = 50) were collected from Shiraz-Iran (2017). The genotyping of the target point in the

RESULTS: Based on the collected data (AA genotype = reference), allele "A" frequency in aborted fetus was 51% and control 68% as well as allele G 49% and 32%, respectively. Moreover, 27 aborted embryos (54%) were heterozygous (A/G) (OR = 3.274, 95% CI = 1.015-10.561, p = 0.04), while 18 cases (36%) in control sample showed heterozygosity. Considering the phenotypic status, the G allele had a dominant effect on the incidence of RSA (p = 0.008, OR = 3.167).

CONCLUSION: Based on the present study, the risk of abortion due to loss of heterozygosity or quantitative decline of the

Copyright © 2020 Ardeshir et al.

Keywords: Gene expression; Genomic imprinting; IGF-2; Spontaneous abortion; Variant

Conflict of interest statement

There is no conflict of interest in this study.

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