Display options
Share it on

Brain Sci. 2020 Oct 20;10(10). doi: 10.3390/brainsci10100756.

Perspectives on Human Hearing Loss, Cochlear Regeneration, and the Potential for Hearing Restoration Therapies.

Brain sciences

Patricia M White

Affiliations

  1. Department of Neuroscience, Ernest J. Del Monte Institute for Neuroscience, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA.

PMID: 33092183 PMCID: PMC7589617 DOI: 10.3390/brainsci10100756

Abstract

Most adults who acquire hearing loss find it to be a disability that is poorly corrected by current prosthetics. This gap drives current research in cochlear mechanosensory hair cell regeneration and in hearing restoration. Birds and fish can spontaneously regenerate lost hair cells through a process that has become better defined in the last few years. Findings from these studies have informed new research on hair cell regeneration in the mammalian cochlea. Hair cell regeneration is one part of the greater problem of hearing restoration, as hearing loss can stem from a myriad of causes. This review discusses these issues and recent findings, and places them in the greater social context of need and community.

Keywords: cochlear regeneration; deaf perspective; hair cell; hearing loss; hearing restoration; noise damage

References

  1. Development. 2019 Feb 15;146(4): - PubMed
  2. Cold Spring Harb Perspect Med. 2019 Aug 1;9(8): - PubMed
  3. Semin Hear. 2019 May;40(2):104-107 - PubMed
  4. PLoS One. 2019 Sep 9;14(9):e0221713 - PubMed
  5. Hear Res. 2013 Jan;295:3-8 - PubMed
  6. J Neurophysiol. 2013 Aug;110(3):577-86 - PubMed
  7. Science. 1988 Jun 24;240(4860):1772-4 - PubMed
  8. J Comp Neurol. 2000 Aug 21;424(2):307-26 - PubMed
  9. Hear Res. 2000 Nov;149(1-2):239-47 - PubMed
  10. Nat Med. 2005 Mar;11(3):271-6 - PubMed
  11. Am J Hum Genet. 2007 Jun;80(6):1055-63 - PubMed
  12. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8167-72 - PubMed
  13. Development. 1999 Feb;126(5):961-73 - PubMed
  14. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):E1393-401 - PubMed
  15. Cell Rep. 2017 Feb 21;18(8):1917-1929 - PubMed
  16. Nat Neurosci. 2000 Jun;3(6):580-6 - PubMed
  17. Dev Cell. 2015 Aug 10;34(3):267-82 - PubMed
  18. JAMA. 1989 Apr 7;261(13):1916-9 - PubMed
  19. Development. 2015 Oct 15;142(20):3529-36 - PubMed
  20. J Neurosci. 2013 Jan 23;33(4):1564-76 - PubMed
  21. Otolaryngol Head Neck Surg. 2019 Aug;161(1_suppl):S1-S45 - PubMed
  22. J Comp Neurol. 1994 Mar 1;341(1):50-67 - PubMed
  23. J Neurosci. 1996 Oct 1;16(19):6157-74 - PubMed
  24. Am Ann Deaf. 2010 Winter;154(5):486-92; discussion 493-6 - PubMed
  25. BMC Neurosci. 2014 May 22;15:66 - PubMed
  26. PLoS Genet. 2006 Jan;2(1):e4 - PubMed
  27. Development. 2008 Jul;135(13):2251-61 - PubMed
  28. Eur J Neurosci. 2018 Nov;48(10):3299-3316 - PubMed
  29. Nat Commun. 2019 Dec 4;10(1):5530 - PubMed
  30. Ann Otol Rhinol Laryngol. 1976 Nov-Dec;85(6 PT. 1):740-51 - PubMed
  31. Development. 2006 Mar;133(5):865-75 - PubMed
  32. J Speech Lang Hear Res. 2007 Oct;50(5):1157-65 - PubMed
  33. Dev Biol. 2012 Mar 1;363(1):191-200 - PubMed
  34. Hear Res. 2013 Mar;297:113-20 - PubMed
  35. Nat Rev Genet. 2007 Jun;8(6):450-61 - PubMed
  36. PLoS Genet. 2018 Jul 31;14(7):e1007552 - PubMed
  37. Science. 1999 Jun 11;284(5421):1837-41 - PubMed
  38. Development. 2019 Jun 21;146(13): - PubMed
  39. Front Mol Neurosci. 2017 Dec 21;10:426 - PubMed
  40. Elife. 2020 Jan 24;9: - PubMed
  41. Occup Environ Med. 2001 Jan;58(1):46-51 - PubMed
  42. PLoS One. 2012;7(1):e30871 - PubMed
  43. J Mol Med (Berl). 2006 Jan;84(1):37-45 - PubMed
  44. Development. 2000 Nov;127(21):4551-60 - PubMed
  45. Laryngoscope. 1990 Dec;100(12):1326-30 - PubMed
  46. J Neurosci. 2015 Jul 29;35(30):10786-98 - PubMed
  47. J Neurosci Res. 2020 Sep;98(9):1698-1704 - PubMed
  48. Laryngoscope. 1991 Nov;101(11):1139-49 - PubMed
  49. Elife. 2017 Sep 27;6: - PubMed
  50. Development. 1998 Dec;125(23):4645-54 - PubMed
  51. J Acoust Soc Am. 2011 Jul;130(1):1-4 - PubMed
  52. Brain Res. 2009 Feb 27;1257:108-16 - PubMed
  53. Acta Otolaryngol. 1976 Mar-Apr;81(3-4):337-43 - PubMed
  54. Am J Otol. 2000 Mar;21(2):188-91 - PubMed
  55. J Neurosci. 2012 Jul 11;32(28):9639-48 - PubMed
  56. PLoS One. 2014 Feb 20;9(2):e89377 - PubMed
  57. J Clin Invest. 2018 Apr 2;128(4):1641-1656 - PubMed
  58. J Neurosci. 2014 Nov 26;34(48):15851-60 - PubMed
  59. Cell. 2018 Aug 23;174(5):1229-1246.e17 - PubMed
  60. Development. 2014 Feb;141(4):816-29 - PubMed
  61. Oncogene. 1999 Jun 17;18(24):3593-607 - PubMed
  62. J Neurosci. 2008 Jul 16;28(29):7350-8 - PubMed
  63. JAMA. 2012 Mar 21;307(11):1147-8 - PubMed
  64. J Neurosci. 2009 Nov 11;29(45):14077-85 - PubMed
  65. Int J Pediatr Otorhinolaryngol. 2009 Dec;73(12):1691-5 - PubMed
  66. Science. 1988 Jun 24;240(4860):1774-6 - PubMed
  67. J Biol Chem. 2010 Jan 1;285(1):392-400 - PubMed
  68. Acta Otolaryngol. 1975 Nov-Dec;80(5-6):375-82 - PubMed
  69. J Deaf Stud Deaf Educ. 2005 Summer;10(3):291-310 - PubMed
  70. Dev Cell. 2009 Jan;16(1):58-69 - PubMed
  71. J Neurosci. 2016 Sep 7;36(36):9479-89 - PubMed
  72. JAMA Otolaryngol Head Neck Surg. 2018 Feb 1;144(2):115-126 - PubMed
  73. Adv Exp Med Biol. 2019;1130:37-57 - PubMed
  74. Arch Otolaryngol. 1976 Feb;102(2):108-11 - PubMed
  75. Mech Ageing Dev. 2010 Jul-Aug;131(7-8):480-6 - PubMed
  76. Development. 2000 Mar;127(6):1185-96 - PubMed
  77. B-ENT. 2013;9(1):23-8 - PubMed
  78. J Gerontol A Biol Sci Med Sci. 2017 May 1;72(5):703-709 - PubMed
  79. Brain. 2002 Jul;125(Pt 7):1583-93 - PubMed
  80. J Neurosci. 2006 Jan 11;26(2):550-8 - PubMed
  81. Semin Cell Dev Biol. 2020 Jan;97:63-73 - PubMed
  82. Hear Res. 1987;30(2-3):181-95 - PubMed
  83. Stem Cell Res Ther. 2019 Dec 2;10(1):365 - PubMed
  84. Dev Biol. 2009 Feb 1;326(1):86-100 - PubMed
  85. Front Cell Neurosci. 2018 May 04;12:120 - PubMed
  86. Front Cell Neurosci. 2015 Mar 31;9:110 - PubMed
  87. Disabil Rehabil. 2002 Oct 15;24(15):763-73 - PubMed
  88. J Neurosci. 2002 Nov 1;22(21):9643-50 - PubMed
  89. Hear Res. 2018 Jul;364:1-11 - PubMed
  90. Otol Neurotol. 2019 Jun;40(5):559-570 - PubMed
  91. J Assoc Res Otolaryngol. 2003 Jun;4(2):219-34 - PubMed
  92. Dev Neurobiol. 2014 Apr;74(4):438-56 - PubMed
  93. Hear Res. 2018 Apr;361:66-79 - PubMed
  94. J Am Acad Audiol. 2006 Jul-Aug;17(7):498-505 - PubMed
  95. Cereb Cortex. 2020 Mar 21;30(2):812-823 - PubMed
  96. Hear Res. 2013 Mar;297:20-9 - PubMed
  97. Arch Otolaryngol Head Neck Surg. 1987 Oct;113(10):1058-62 - PubMed
  98. Hear Res. 2005 Jun;204(1-2):90-100 - PubMed
  99. J Neurosci. 1996 Jan 15;16(2):649-62 - PubMed
  100. Dev Dyn. 2007 Jan;236(1):156-70 - PubMed
  101. Infect Dis Ther. 2018 Dec;7(4):421-438 - PubMed
  102. Arch Otolaryngol Head Neck Surg. 2001 Mar;127(3):253-8 - PubMed
  103. Otol Neurotol. 2014 Jun;35(5):775-81 - PubMed
  104. Elife. 2019 Jan 25;8: - PubMed
  105. PLoS One. 2007 Jun 13;2(6):e525 - PubMed
  106. Development. 2007 May;134(9):1713-22 - PubMed
  107. PLoS One. 2016 Dec 5;11(12):e0167286 - PubMed
  108. Neuron. 2013 Jan 9;77(1):58-69 - PubMed
  109. Mol Ther. 2018 May 2;26(5):1313-1326 - PubMed
  110. Otol Neurotol. 2017 Jul;38(6):792-803 - PubMed
  111. Nature. 2006 Jun 22;441(7096):984-7 - PubMed
  112. Genes Dev. 2002 Sep 15;16(18):2365-78 - PubMed
  113. Front Mol Neurosci. 2020 Feb 05;13:13 - PubMed
  114. Curr Biol. 2009 May 12;19(9):R381-6 - PubMed
  115. Adv Exp Med Biol. 2019;1130:17-36 - PubMed
  116. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):E1383-92 - PubMed
  117. J Neurosci. 2019 Jun 5;39(23):4434-4447 - PubMed
  118. J Neurosci. 2002 Dec 15;22(24):10838-46 - PubMed
  119. J Assoc Res Otolaryngol. 2011 Oct;12(5):605-16 - PubMed
  120. Nat Genet. 1997 Feb;15(2):186-9 - PubMed
  121. Nature. 2018 Jan 11;553(7687):217-221 - PubMed
  122. Mol Ther. 2019 May 8;27(5):904-911 - PubMed
  123. J Assoc Res Otolaryngol. 2003 Sep;4(3):422-43 - PubMed
  124. Cell Rep. 2017 Apr 11;19(2):307-320 - PubMed
  125. J Neurocytol. 1992 Sep;21(9):663-71 - PubMed
  126. Hear Res. 2017 Jun;349:182-196 - PubMed
  127. Hear Res. 2020 Jan;385:107839 - PubMed
  128. J Biol Chem. 2002 Aug 23;277(34):30998-1004 - PubMed
  129. Semin Cell Dev Biol. 2017 May;65:96-105 - PubMed
  130. Development. 2018 Nov 27;145(23): - PubMed
  131. Anat Rec (Hoboken). 2020 Mar;303(3):461-470 - PubMed

Publication Types

Grant support