Display options
Cite
Zeng L, Wang S, Cai J, et al. Clinical characteristics of COVID-19 with cardiac injury: a systematic review and meta-analysis. Epidemiol Infect. 2020;148:e266doi: 10.1017/S0950268820002587.
Zeng, L., Wang, S., Cai, J., Sun, S., Wang, S., Li, J., & Sun, L. (2020). Clinical characteristics of COVID-19 with cardiac injury: a systematic review and meta-analysis. Epidemiology and infection, 148e266. https://doi.org/10.1017/S0950268820002587
Zeng, Linwen, et al. "Clinical characteristics of COVID-19 with cardiac injury: a systematic review and meta-analysis." Epidemiology and infection vol. 148 (2020): e266. doi: https://doi.org/10.1017/S0950268820002587
Zeng L, Wang S, Cai J, Sun S, Wang S, Li J, Sun L. Clinical characteristics of COVID-19 with cardiac injury: a systematic review and meta-analysis. Epidemiol Infect. 2020 Oct 23;148:e266. doi: 10.1017/S0950268820002587. PMID: 33092664; PMCID: PMC7653493.
Copy Download .nbib Format: NLM
Share it on

Epidemiol Infect. 2020 Oct 23;148:e266. doi: 10.1017/S0950268820002587.

Clinical characteristics of COVID-19 with cardiac injury: a systematic review and meta-analysis.

Epidemiology and infection

Linwen Zeng, Shihui Wang, Jianing Cai, Shaoqing Sun, Suhuai Wang, Jingjie Li, Lin Sun

Affiliations

  1. Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

PMID: 33092664 PMCID: PMC7653493 DOI: 10.1017/S0950268820002587

Abstract

OBJECTIVES: Cardiac injury is associated with poor prognosis of 2019 novel coronavirus disease 2019 (COVID-19), but the risk factors for cardiac injury have not been fully studied. In this study, we carried out a systematic analysis of clinical characteristics in COVID-19 patients to determine potential risk factors for cardiac injury complicated COVID-19 virus infection.

METHODS: We systematically searched relevant literature published in Pubmed, Embase, Europe PMC, CNKI and other databases. All statistical analyses were performed using STATA 16.0.

RESULTS: We analysed 5726 confirmed cases from 17 studies. The results indicated that compared with non-cardiac-injured patients, patients with cardiac injury are older, with a greater proportion of male patients, with higher possibilities of existing comorbidities, with higher risks of clinical complications, need for mechanical ventilation, ICU transfer and mortality. Moreover, C-reactive protein, procalcitonin, D-dimer, NT-proBNP and blood creatinine in patients with cardiac injury are also higher while lymphocyte counts and platelet counts decreased. However, we fortuitously found that patients with cardiac injury did not present higher clinical specificity for chest distress (P = 0.304), chest pain (P = 0.334), palpitations (P = 0.793) and smoking (P = 0.234). Similarly, the risk of concomitant arrhythmia (P = 0.103) did not increase observably either.

CONCLUSION: Age, male gender and comorbidities are risk factors for cardiac injury complicated COVID-19 infection. Such patients are susceptible to complications and usually have abnormal results of laboratory tests, leading to poor outcomes. Contrary to common cardiac diseases, cardiac injury complicated COVID-19 infection did not significantly induce chest distress, chest pain, palpitations or arrhythmias. Our study indicates that early prevention should be applied to COVID-19 patients with cardiac injury to reduce adverse outcomes.

Keywords: COVID-19; Cardiac injury; coronavirus; meta analysis

References

  1. BMC Med Res Methodol. 2014 Dec 19;14:135 - PubMed
  2. Clin Infect Dis. 2020 May 03;: - PubMed
  3. Cell Mol Immunol. 2015 Nov;12(6):768-76 - PubMed
  4. Circulation. 2020 Jul 7;142(1):68-78 - PubMed
  5. Science. 2017 Mar 31;355(6332):1433-1436 - PubMed
  6. J Med Virol. 2020 Apr 16;: - PubMed
  7. Prog Cardiovasc Dis. 2020 Jul - Aug;63(4):518-524 - PubMed
  8. Intern Emerg Med. 2020 Nov;15(8):1415-1424 - PubMed
  9. Circ Res. 2016 Feb 5;118(3):496-514 - PubMed
  10. JAMA. 2020 Apr 7;323(13):1239-1242 - PubMed
  11. J Am Coll Cardiol. 2020 Aug 4;76(5):533-546 - PubMed
  12. J Med Virol. 2020 May 8;: - PubMed
  13. Am J Cardiol. 2020 Oct 15;133:154-161 - PubMed
  14. J Cardiovasc Electrophysiol. 2020 May;31(5):1003-1008 - PubMed
  15. JAMA. 2020 Mar 17;323(11):1061-1069 - PubMed
  16. Stat Methods Med Res. 2018 Jun;27(6):1785-1805 - PubMed
  17. JAMA Cardiol. 2020 Jul 1;5(7):811-818 - PubMed
  18. Lancet. 2020 Mar 28;395(10229):1054-1062 - PubMed
  19. J Allergy Clin Immunol. 2020 Jul;146(1):110-118 - PubMed
  20. Intensive Care Med. 2020 Jun;46(6):1294-1297 - PubMed
  21. J Am Heart Assoc. 2020 Sep 15;9(18):e016807 - PubMed
  22. Heart. 2020 Aug;106(15):1154-1159 - PubMed
  23. Am J Emerg Med. 2020 Apr 19;: - PubMed
  24. Int J Biol Sci. 2020 Feb 21;16(8):1349-1362 - PubMed
  25. JAMA Cardiol. 2020 Jul 1;5(7):802-810 - PubMed
  26. BMJ. 2020 Mar 26;368:m1091 - PubMed
  27. J Med Virol. 2020 Mar 17;: - PubMed
  28. Zhonghua Xin Xue Guan Bing Za Zhi. 2020 Jun 24;48(6):450-455 - PubMed
  29. Lancet. 2020 Mar 28;395(10229):1033-1034 - PubMed
  30. Ann Am Thorac Soc. 2020 Jul;17(7):839-846 - PubMed
  31. Chin Med J (Engl). 2020 Jun 5;133(11):1261-1267 - PubMed

MeSH terms

Publication Types