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J Clin Med. 2020 Oct 31;9(11). doi: 10.3390/jcm9113524.

Effects of Netarsudil on Actin-Driven Cellular Functions in Normal and Glaucomatous Trabecular Meshwork Cells: A Live Imaging Study.

Journal of clinical medicine

Kate E Keller, Casey Kopczynski

Affiliations

  1. Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
  2. Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR 97239, USA.
  3. Aerie Pharmaceuticals, Durham, NC 27703, USA.

PMID: 33142742 PMCID: PMC7693753 DOI: 10.3390/jcm9113524

Abstract

The actin cytoskeleton of trabecular meshwork (TM) cells is a therapeutic target for lowering intraocular pressure (IOP) in glaucoma patients. Netarsudil (the active ingredient in Rhopressa

Keywords: actin cytoskeleton; extracellular vesicles; glaucoma; live cell imaging; trabecular meshwork; tunneling nanotubes

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