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Feng J, Leung AWK, Cheng FWT, et al. t(1;22)(p13;q13) Acute Megakaryoblastic Leukemia Complicated by Hepatic Fibrosis: Antifibrosis Therapy?. J Pediatr Hematol Oncol. 2021;43(8):e1164-e1167doi: 10.1097/MPH.0000000000001986.
Feng, J., Leung, A. W. K., Cheng, F. W. T., Lam, G. K. S., Chow, T. T. W., Ng, M. H. L., Chu, W. C. W., Chan, N. P. H., & Li, C. K. (2021). t(1;22)(p13;q13) Acute Megakaryoblastic Leukemia Complicated by Hepatic Fibrosis: Antifibrosis Therapy?. Journal of pediatric hematology/oncology, 43(8), e1164-e1167. https://doi.org/10.1097/MPH.0000000000001986
Feng, Jianhua, et al. "t(1;22)(p13;q13) Acute Megakaryoblastic Leukemia Complicated by Hepatic Fibrosis: Antifibrosis Therapy?." Journal of pediatric hematology/oncology vol. 43,8 (2021): e1164-e1167. doi: https://doi.org/10.1097/MPH.0000000000001986
Feng J, Leung AWK, Cheng FWT, Lam GKS, Chow TTW, Ng MHL, Chu WCW, Chan NPH, Li CK. t(1;22)(p13;q13) Acute Megakaryoblastic Leukemia Complicated by Hepatic Fibrosis: Antifibrosis Therapy?. J Pediatr Hematol Oncol. 2021 Nov 01;43(8):e1164-e1167. doi: 10.1097/MPH.0000000000001986. PMID: 33122587.
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J Pediatr Hematol Oncol. 2021 Nov 01;43(8):e1164-e1167. doi: 10.1097/MPH.0000000000001986.

t(1;22)(p13;q13) Acute Megakaryoblastic Leukemia Complicated by Hepatic Fibrosis: Antifibrosis Therapy?.

Journal of pediatric hematology/oncology

Jianhua Feng, Alex W K Leung, Frankie W T Cheng, Grace K S Lam, Terry T W Chow, Margaret H L Ng, Winnie C W Chu, Natalie P H Chan, Chi-Kong Li

Affiliations

  1. Departments of Paediatrics.
  2. Department of Paediatrics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, PR China.
  3. Anatomincal & Cellular Pathology.
  4. Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR.

PMID: 33122587 DOI: 10.1097/MPH.0000000000001986

Abstract

BACKGROUND: There is no established effective treatment for patients with t(1;22)(p13;q13) acute megakaryoblastic leukemia (AMKL) and hepatic fibrosis.

OBSERVATION: Here we report the outcomes of 2 t(1;22)(p13;q13) AMKL patients with hepatic fibrosis. One patient died from liver failure despite the control of leukemia. The other patient was successfully treated with reduced-intensity chemotherapy and antifibrosis therapy with tretinoin and α-tocopheryl acetate, the hepatic fibrosis resolved and leukemia was in remission for 3 years.

CONCLUSIONS: Reduced-intensity chemotherapy plus antifibrosis therapy with tretinoin and α-tocopheryl acetate could be a treatment option for these patients with t(1;22)(p13;q13) AMKL and hepatic fibrosis.

Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.

Conflict of interest statement

The authors declare no conflict of interest.

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