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Bordonne M, Chawki MB, Marie PY, et al. High-quality brain perfusion SPECT images may be achieved with a high-speed recording using 360° CZT camera. EJNMMI Phys. 2020;7(1):65doi: 10.1186/s40658-020-00334-7.
Bordonne, M., Chawki, M. B., Marie, P. Y., Zaragori, T., Roch, V., Grignon, R., Imbert, L., & Verger, A. (2020). High-quality brain perfusion SPECT images may be achieved with a high-speed recording using 360° CZT camera. EJNMMI physics, 7(1), 65. https://doi.org/10.1186/s40658-020-00334-7
Bordonne, Manon, et al. "High-quality brain perfusion SPECT images may be achieved with a high-speed recording using 360° CZT camera." EJNMMI physics vol. 7,1 (2020): 65. doi: https://doi.org/10.1186/s40658-020-00334-7
Bordonne M, Chawki MB, Marie PY, Zaragori T, Roch V, Grignon R, Imbert L, Verger A. High-quality brain perfusion SPECT images may be achieved with a high-speed recording using 360° CZT camera. EJNMMI Phys. 2020 Nov 04;7(1):65. doi: 10.1186/s40658-020-00334-7. PMID: 33146804; PMCID: PMC7642149.
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EJNMMI Phys. 2020 Nov 04;7(1):65. doi: 10.1186/s40658-020-00334-7.

High-quality brain perfusion SPECT images may be achieved with a high-speed recording using 360° CZT camera.

EJNMMI physics

Manon Bordonne, Mohammad B Chawki, Pierre-Yves Marie, Timothée Zaragori, Véronique Roch, Rachel Grignon, Laetitia Imbert, Antoine Verger

Affiliations

  1. Department of Nuclear Medicine and Nancyclotep Imaging Platform, CHRU-Nancy, Université de Lorraine, F-54000, Nancy, France.
  2. Médecine Nucléaire, CHRU-Nancy Brabois, Allée du Morvan, 54500 Vandoeuvre-lès-, Nancy, France.
  3. Université de Lorraine, INSERM, UMR-1116 DCAC, F-54000, Nancy, France.
  4. Université de Lorraine, INSERM U1254, IADI, F-54000, Nancy, France.
  5. Department of Nuclear Medicine and Nancyclotep Imaging Platform, CHRU-Nancy, Université de Lorraine, F-54000, Nancy, France. [email protected].
  6. Médecine Nucléaire, CHRU-Nancy Brabois, Allée du Morvan, 54500 Vandoeuvre-lès-, Nancy, France. [email protected].
  7. Université de Lorraine, INSERM U1254, IADI, F-54000, Nancy, France. [email protected].

PMID: 33146804 PMCID: PMC7642149 DOI: 10.1186/s40658-020-00334-7

Abstract

OBJECTIVE: The aim of this study was to compare brain perfusion SPECT obtained from a 360° CZT and a conventional Anger camera.

METHODS: The 360° CZT camera utilizing a brain configuration, with 12 detectors surrounding the head, was compared to a 2-head Anger camera for count sensitivity and image quality on 30-min SPECT recordings from a brain phantom and from

RESULTS: The CZT camera provided more than 2-fold increase in count sensitivity, as compared with the Anger camera, as well as (1) lower sharpness indexes, giving evidence of higher spatial resolution, for both peripheral/central brain structures, with respective median values of 5.2%/3.7% versus 2.4%/1.9% for CZT and Anger camera respectively in patients (p < 0.01), and 8.0%/6.9% versus 6.2%/3.7% on phantom; and (2) higher gray/white matter contrast on peripheral/central structures, with respective ratio median values of 1.56/1.35 versus 1.11/1.20 for CZT and Anger camera respectively in patients (p < 0.05), and 2.57/2.17 versus 1.40/1.12 on phantom; and (3) no change in noise level. Image quality, scored visually by experienced physicians, was also significantly higher on CZT than on the Anger camera (+ 80%, p < 0.01), and all these results were unchanged on the CZT images obtained with only a 15 min recording time.

CONCLUSION: The 360° CZT camera provides brain perfusion images of much higher quality than a conventional Anger camera, even with high-speed recordings, thus demonstrating the potential for repositioning brain perfusion SPECT to the forefront of brain imaging.

Keywords: Brain perfusion; CZT; Count sensitivity; Image quality; SPECT

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