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Lee D, Jo MG, Kim SY, et al. Dietary Antioxidants and the Mitochondrial Quality Control: Their Potential Roles in Parkinson's Disease Treatment. Antioxidants (Basel). 2020;9(11)doi: 10.3390/antiox9111056.
Lee, D., Jo, M. G., Kim, S. Y., Chung, C. G., & Lee, S. B. (2020). Dietary Antioxidants and the Mitochondrial Quality Control: Their Potential Roles in Parkinson's Disease Treatment. Antioxidants (Basel, Switzerland), 9(11), . https://doi.org/10.3390/antiox9111056
Lee, Davin, et al. "Dietary Antioxidants and the Mitochondrial Quality Control: Their Potential Roles in Parkinson's Disease Treatment." Antioxidants (Basel, Switzerland) vol. 9,11 (2020). doi: https://doi.org/10.3390/antiox9111056
Lee D, Jo MG, Kim SY, Chung CG, Lee SB. Dietary Antioxidants and the Mitochondrial Quality Control: Their Potential Roles in Parkinson's Disease Treatment. Antioxidants (Basel). 2020 Oct 28;9(11). doi: 10.3390/antiox9111056. PMID: 33126703; PMCID: PMC7692176.
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Antioxidants (Basel). 2020 Oct 28;9(11). doi: 10.3390/antiox9111056.

Dietary Antioxidants and the Mitochondrial Quality Control: Their Potential Roles in Parkinson's Disease Treatment.

Antioxidants (Basel, Switzerland)

Davin Lee, Min Gu Jo, Seung Yeon Kim, Chang Geon Chung, Sung Bae Lee

Affiliations

  1. Department of Brain & Cognitive Sciences, DGIST, Daegu 42988, Korea.
  2. Protein Dynamics-Based Proteotoxicity Control Laboratory, Basic Research Lab, DGIST, Daegu 42988, Korea.

PMID: 33126703 PMCID: PMC7692176 DOI: 10.3390/antiox9111056

Abstract

Advances in medicine and dietary standards over recent decades have remarkably increased human life expectancy. Unfortunately, the chance of developing age-related diseases, including neurodegenerative diseases (NDDs), increases with increased life expectancy. High metabolic demands of neurons are met by mitochondria, damage of which is thought to contribute to the development of many NDDs including Parkinson's disease (PD). Mitochondrial damage is closely associated with the abnormal production of reactive oxygen species (ROS), which are widely known to be toxic in various cellular environments, including NDD contexts. Thus, ways to prevent or slow mitochondrial dysfunction are needed for the treatment of these NDDs. In this review, we first detail how ROS are associated with mitochondrial dysfunction and review the cellular mechanisms, such as the mitochondrial quality control (MQC) system, by which neurons defend against both abnormal production of ROS and the subsequent accumulation of damaged mitochondria. We next highlight previous studies that link mitochondrial dysfunction with PD and how dietary antioxidants might provide reinforcement of the MQC system. Finally, we discuss how aging plays a role in mitochondrial dysfunction and PD before considering how healthy aging through proper diet and exercise may be salutary.

Keywords: Parkinson’s disease; dietary antioxidants; mitochondria; mitochondrial quality control; neurodegenerative disease; reactive oxygen species

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