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Front Physiol. 2020 Sep 23;11:1113. doi: 10.3389/fphys.2020.01113. eCollection 2020.

The Role of Cardiac Macrophage and Cytokines on Ventricular Arrhythmias.

Frontiers in physiology

Mingxian Chen, Xuping Li, Songyun Wang, Lilei Yu, Jianjun Tang, Shenghua Zhou

Affiliations

  1. The Second Xiangya Hospital, Central South University, Changsha, China.
  2. Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.

PMID: 33071805 PMCID: PMC7540080 DOI: 10.3389/fphys.2020.01113

Abstract

In the heart, cardiac macrophages have widespread biological functions, including roles in antigen presentation, phagocytosis, and immunoregulation, through the formation of diverse cytokines and growth factors; thus, these cells play an active role in tissue repair after heart injury. Recent clinical studies have indicated that macrophages or elevated inflammatory cytokines secreted by macrophages are closely related to ventricular arrhythmias (VAs). This review describes the role of macrophages and macrophage-secreted inflammatory cytokines in ventricular arrhythmogenesis.

Copyright © 2020 Chen, Li, Wang, Yu, Tang and Zhou.

Keywords: connexin43; cytokines; electrophysiology; macrophage; ventricular arrhythmias

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