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Bărboi OB, Ciortescu I, Chirilă I, et al. Effect of inulin in the treatment of irritable bowel syndrome with constipation (Review). Exp Ther Med. 2020;20(6):185doi: 10.3892/etm.2020.9315.
Bărboi, O. B., Ciortescu, I., Chirilă, I., Anton, C., & Drug, V. (2020). Effect of inulin in the treatment of irritable bowel syndrome with constipation (Review). Experimental and therapeutic medicine, 20(6), 185. https://doi.org/10.3892/etm.2020.9315
Bărboi, Oana-Bogdana, et al. "Effect of inulin in the treatment of irritable bowel syndrome with constipation (Review)." Experimental and therapeutic medicine vol. 20,6 (2020): 185. doi: https://doi.org/10.3892/etm.2020.9315
Bărboi OB, Ciortescu I, Chirilă I, Anton C, Drug V. Effect of inulin in the treatment of irritable bowel syndrome with constipation (Review). Exp Ther Med. 2020 Dec;20(6):185. doi: 10.3892/etm.2020.9315. Epub 2020 Oct 13. PMID: 33101475; PMCID: PMC7579772.
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Exp Ther Med. 2020 Dec;20(6):185. doi: 10.3892/etm.2020.9315. Epub 2020 Oct 13.

Effect of inulin in the treatment of irritable bowel syndrome with constipation (Review).

Experimental and therapeutic medicine

Oana-Bogdana Bărboi, Irina Ciortescu, Ioan Chirilă, Carmen Anton, Vasile Drug

Affiliations

  1. Department of Gastroenterology, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.
  2. Institute of Gastroenterology and Hepatology, 'Saint Spiridon' Hospital, 700111 Iasi, Romania.
  3. Health Related to Environment Department, National Institute of Public Health, 700506 Iasi, Romania.

PMID: 33101475 PMCID: PMC7579772 DOI: 10.3892/etm.2020.9315

Abstract

At present, irritable bowel syndrome (IBS) is a common medical problem all over the world that implies considerable social burden and high costs. Considering the different pathophysiological pathways, unitary management for IBS is not possible. Of the therapeutic approaches that have been proposed so far, only a few have been demonstrated to have beneficial effects in IBS patients. The implication of gut microbiota in IBS is obvious, similarly to the therapeutic effect of pro-/prebiotics, which is reflected by the latest publications. The intake of inulin seems to regulate the bowel peristalsis and colonic transit, the consistency and frequency of the stools, as it changes the composition of gut microbiota. The beneficial effect of inulin in patients with IBS-constipation form (IBS-C) is obvious, but still, more randomized controlled clinical trials involving large samples of patients are needed in order to provide more evidence.

Copyright © 2020, Spandidos Publications.

Keywords: constipation; gut microbiota; inulin; irritable bowel syndrome; prebiotic; probiotic

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