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Karmaniolou I, Lamprou K, Staikou C, et al. Effect of Triiodothyronine Administration on the Kidney During Haemorrhagic Shock and Resuscitation. Turk J Anaesthesiol Reanim. 2020;48(5):406-413doi: 10.5152/TJAR.2019.81542.
Karmaniolou, I., Lamprou, K., Staikou, C., Giamarellos-Bourboulis, E., Theodoraki, K., Papalois, A., Mylonas, A., Orfanos, N., Smyrniotis, V., & Arkadopoulos, N. (2020). Effect of Triiodothyronine Administration on the Kidney During Haemorrhagic Shock and Resuscitation. Turkish journal of anaesthesiology and reanimation, 48(5), 406-413. https://doi.org/10.5152/TJAR.2019.81542
Karmaniolou, Iosifina, et al. "Effect of Triiodothyronine Administration on the Kidney During Haemorrhagic Shock and Resuscitation." Turkish journal of anaesthesiology and reanimation vol. 48,5 (2020): 406-413. doi: https://doi.org/10.5152/TJAR.2019.81542
Karmaniolou I, Lamprou K, Staikou C, Giamarellos-Bourboulis E, Theodoraki K, Papalois A, Mylonas A, Orfanos N, Smyrniotis V, Arkadopoulos N. Effect of Triiodothyronine Administration on the Kidney During Haemorrhagic Shock and Resuscitation. Turk J Anaesthesiol Reanim. 2020 Oct;48(5):406-413. doi: 10.5152/TJAR.2019.81542. Epub 2020 Feb 05. PMID: 33103146; PMCID: PMC7556640.
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Turk J Anaesthesiol Reanim. 2020 Oct;48(5):406-413. doi: 10.5152/TJAR.2019.81542. Epub 2020 Feb 05.

Effect of Triiodothyronine Administration on the Kidney During Haemorrhagic Shock and Resuscitation.

Turkish journal of anaesthesiology and reanimation

Iosifina Karmaniolou, Konstantinos Lamprou, Chryssoula Staikou, Evangelos Giamarellos-Bourboulis, Kassiani Theodoraki, Apostolos Papalois, Anastasios Mylonas, Nikolaos Orfanos, Vassilios Smyrniotis, Nikolaos Arkadopoulos

Affiliations

  1. Department of Anaesthesia, Guy's and St Thomas' NHS Foundation Trust, London, UK.
  2. Department of Obstetrics and Gynaecology, Bradford Royal Infirmary, Bradford, UK.
  3. 1 Department of Anaesthesia, Aretaieion Hospital, University of Athens Medical School, Athens, Greece.
  4. 4 Department of Internal Medicine, Attikon Hospital, Medical School, University of Athens, Chaidari, Greece.
  5. Experimental-Research Center ELPEN Pharmaceuticals, Pikermi, Greece.
  6. 4 Department of Surgery, Attikon Hospital, Medical School, University of Athens, Chaidari, Greece.

PMID: 33103146 PMCID: PMC7556640 DOI: 10.5152/TJAR.2019.81542

Abstract

OBJECTIVE: Apoptosis, measured via caspase activity, can be used to assess renal tissue damage in haemorrhagic shock. We investigated whether Triiodothyronine could attenuate apoptosis and protect against haemorrhagic shock-induced renal injury.

METHODS: Haemorrhagic shock was induced in swine until the mean arterial pressure (MAP) was 35-40 mmHg for 40 minutes. Animals were randomly assigned to a control group (n=5), Group-F (Fluid resuscitation, n=6), and Group-T3 (Fluid plus Triiodothyronine, n=6). The swine were resuscitated for 1 hour aiming to MAP restoration (±10% from baseline) and were followed up for another 360 minutes. Haemodynamic parameters, fluids, acid-base status, plasma urea nitrogen, creatinine levels and caspase activity in the kidney were measured.

RESULTS: Haemodynamic parameters did not differ significantly amongst the three groups. Group-T3 required less normal saline (Group-T3: 1083±204 mL versus F: 2500±547 mL, p=0.001) and hydroxyethyl starch (Group-T3: 558±102 mL versus F: 916±204 mL, p=0.004) during resuscitation. Additionally, Group-T3 swine experienced less acidosis following haemorrhage/resuscitation with a pH of 7.39 versus a pH of 7.26 in Group-F (p=0.004) at 360 minutes. Urea remained within normal limits in all groups, but creatinine levels were elevated at 6 hours in Group-F as compared to Group-T3 (p=0.019). Apoptosis, assessed by renal caspase-3 activity, was increased in Group-T3 (132±174 pmol minute

CONCLUSION: Administration of Triiodothyronine in a swine model of haemorrhagic shock seems to interfere with renal cell apoptosis. The exact mechanism needs to be further investigated in future research.

© Copyright 2020 by Turkish Anaesthesiology and Intensive Care Society.

Keywords: Apoptosis; haemorrhagic shock; kidney; resuscitation; triiodothyronine

Conflict of interest statement

Conflict of Interest: The authors have no conflicts of interest to declare.

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