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Brown JC, Shang H, Yang N, et al. Autologous Fat Transfer for Scar Prevention and Remodeling: A Randomized, Blinded, Placebo-controlled Trial. Plast Reconstr Surg Glob Open. 2020;8(5):e2830doi: 10.1097/GOX.0000000000002830.
Brown, J. C., Shang, H., Yang, N., Pierson, J., Ratliff, C. R., Prince, N., Roney, N., Chan, R., Hatem, V., Gittleman, H., Barnholtz-Sloan, J. S., Vincek, V., & Katz, A. J. (2020). Autologous Fat Transfer for Scar Prevention and Remodeling: A Randomized, Blinded, Placebo-controlled Trial. Plastic and reconstructive surgery. Global open, 8(5), e2830. https://doi.org/10.1097/GOX.0000000000002830
Brown, J Christian, et al. "Autologous Fat Transfer for Scar Prevention and Remodeling: A Randomized, Blinded, Placebo-controlled Trial." Plastic and reconstructive surgery. Global open vol. 8,5 (2020): e2830. doi: https://doi.org/10.1097/GOX.0000000000002830
Brown JC, Shang H, Yang N, Pierson J, Ratliff CR, Prince N, Roney N, Chan R, Hatem V, Gittleman H, Barnholtz-Sloan JS, Vincek V, Katz AJ. Autologous Fat Transfer for Scar Prevention and Remodeling: A Randomized, Blinded, Placebo-controlled Trial. Plast Reconstr Surg Glob Open. 2020 May 27;8(5):e2830. doi: 10.1097/GOX.0000000000002830. eCollection 2020 May. PMID: 33154872; PMCID: PMC7605847.
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Plast Reconstr Surg Glob Open. 2020 May 27;8(5):e2830. doi: 10.1097/GOX.0000000000002830. eCollection 2020 May.

Autologous Fat Transfer for Scar Prevention and Remodeling: A Randomized, Blinded, Placebo-controlled Trial.

Plastic and reconstructive surgery. Global open

J Christian Brown, Hulan Shang, Ning Yang, Justine Pierson, Catherine R Ratliff, Noah Prince, Nicholas Roney, Rodney Chan, Victoria Hatem, Haley Gittleman, Jill S Barnholtz-Sloan, Vladimir Vincek, Adam J Katz

Affiliations

  1. Department of Surgery, University of Florida, Gainesville, Fla.
  2. Department of Plastic and Reconstructive Surgery, Wake Forest University, Winston Salem, N.C.
  3. Department of Plastic Surgery, University of Virginia Health System, Charlottesville, Va.
  4. Department of Plastic Surgery, Loma Linda University, Loma Linda, Calif.
  5. United States Army Institute of Surgical Research, Fort Sam, Houston, Tex.
  6. Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio.
  7. Department of Dermatology, University of Florida, Gainesville, Fla.

PMID: 33154872 PMCID: PMC7605847 DOI: 10.1097/GOX.0000000000002830

Abstract

Autologous fat transfer-also referred to as fat grafting-has been reported to provide beneficial effects to overlying scar and skin. Despite procedural frequency, there is a paucity of high-level evidence guiding the surgeon in technique, patient selection, and efficacy.

METHODS: A multicenter, double-blinded, randomized, internally placebo-controlled trial was performed with an aim to qualitatively and quantitatively evaluate the impact of autologous fat transfer on the quality of overlying scar tissue. Fat-grafted scars were evaluated and compared with paired, saline-injected "control" scars. Subjective and objective metrics were evaluated in treated sites for 12 months after treatment.

RESULTS: Blinded qualitative results demonstrated a statistically significant improvement in scar quality over time in fat-grafted scars. However, these improvements were not found to be statistically different from changes noted in scars treated with saline. In addition, objective metrics did not statistically differ between saline-injected and autologous fat-grafted scars.

CONCLUSIONS: Our results demonstrate that autologous fat grafting can improve the qualitative profile of a scar from both the patient and observer perspectives. However, there was no difference in improvement when compared with scars that were treated with saline in a randomized and blinded fashion. These results demonstrate that any improvements in scar quality related to fat grafting are also achieved using saline and suggest that mechanisms other than cell activity may be at play. Additional randomized, blinded, placebo-controlled trials are required to either corroborate or contest the putative beneficial effect(s) of adipose tissue on scar remodeling.

Copyright © 2020 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.

Conflict of interest statement

Disclosure: The authors have no financial interest to declare in relation to the content of this article. This study was funded by the Armed Forces Institute of Regenerative Medicine (AFIRM)/US Army M

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