Display options
Cite
Tripathy SK, Gantaguru A, Nanda SN, et al. Association of vitamin D and knee osteoarthritis in younger individuals. World J Orthop. 2020;11(10):418-425doi: 10.5312/wjo.v11.i10.418.
Tripathy, S. K., Gantaguru, A., Nanda, S. N., Velagada, S., Srinivasan, A., & Mangaraj, M. (2020). Association of vitamin D and knee osteoarthritis in younger individuals. World journal of orthopedics, 11(10), 418-425. https://doi.org/10.5312/wjo.v11.i10.418
Tripathy, Sujit Kumar, et al. "Association of vitamin D and knee osteoarthritis in younger individuals." World journal of orthopedics vol. 11,10 (2020): 418-425. doi: https://doi.org/10.5312/wjo.v11.i10.418
Tripathy SK, Gantaguru A, Nanda SN, Velagada S, Srinivasan A, Mangaraj M. Association of vitamin D and knee osteoarthritis in younger individuals. World J Orthop. 2020 Oct 18;11(10):418-425. doi: 10.5312/wjo.v11.i10.418. eCollection 2020 Oct 18. PMID: 33134104; PMCID: PMC7582112.
Copy Download .nbib Format: NLM
Share it on

World J Orthop. 2020 Oct 18;11(10):418-425. doi: 10.5312/wjo.v11.i10.418. eCollection 2020 Oct 18.

Association of vitamin D and knee osteoarthritis in younger individuals.

World journal of orthopedics

Sujit Kumar Tripathy, Amrit Gantaguru, Saurav Narayan Nanda, Sandeep Velagada, Anand Srinivasan, Manaswini Mangaraj

Affiliations

  1. Department of Orthopaedics, All India Institute of Medical Sciences, Bhubaneswar, Bhubaneswar 751019, Odisha, India. [email protected].
  2. Department of Orthopaedics, All India Institute of Medical Sciences, Bhubaneswar, Bhubaneswar 751019, Odisha, India.
  3. Department of Pharmacology, AIIMS Bhubaneswar, Bhubaneswar 751019, Odisha, India.
  4. Department of Biochemistry, AIIMS Bhubaneswar, Bhubaneswar 751019, Odisha, India.

PMID: 33134104 PMCID: PMC7582112 DOI: 10.5312/wjo.v11.i10.418

Abstract

BACKGROUND: The incidence of primary osteoarthritis knee is gradually increasing among young individuals. The increasing prevalence of obesity, sedentary lifestyle, sporting activity, and vitamin D deficiency (VDD) has been hypothesized for this shifting disease trend. This study was designed to look for the association of serum vitamin D among these young arthritic patients.

AIM: To look for the association of serum vitamin D in younger knee osteoarthritis (KOA) patients.

METHODS: In a 2-year observational study, 146 non-obese KOA patients of 35-60 years were evaluated clinically (Knee injury and Osteoarthritis Outcome Score, KOOS) and radiologically (Kellegren-Lawrence stage, KL). The serum 25(OH)D level of these patients and 146 normal healthy individuals of same age group were estimated.

RESULTS: Both the groups were comparable in terms of age and sex. The average serum 25(OH)D level in healthy individuals and KOA patients was 45.83 ng/mL and 34.58 ng/mL, respectively (

CONCLUSION: The serum 25(OH)D level is significantly low in younger KOA patients. However, the clinical and radiological severities have no association with serum vitamin D level.

©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

Keywords: Arthroplasty; Cholecalciferol; Degenerative disease; Early-onset arthritis; Knee joint; Knee replacement; Sunlight

Conflict of interest statement

Conflict-of-interest statement: The authors declare that there are no conflicts of interest.

References

  1. Scand J Rheumatol. 2012 Mar;41(2):124-31 - PubMed
  2. Arthritis Rheum. 2012 Dec;64(12):3926-35 - PubMed
  3. Indian J Med Res. 2008 Mar;127(3):229-38 - PubMed
  4. Rheumatol Int. 2017 Sep;37(9):1489-1498 - PubMed
  5. Ann Rheum Dis. 2014 Apr;73(4):697-703 - PubMed
  6. J Clin Orthop Trauma. 2019 Jan-Feb;10(1):9-15 - PubMed
  7. Best Pract Res Clin Rheumatol. 2008 Aug;22(4):657-75 - PubMed
  8. Arthritis Rheum. 2005 Dec 15;53(6):821-6 - PubMed
  9. Osteoarthritis Cartilage. 2016 Nov;24(11):1858-1866 - PubMed
  10. Int Orthop. 2011 Nov;35(11):1627-31 - PubMed
  11. Osteoarthritis Cartilage. 2015 Aug;23(8):1276-84 - PubMed
  12. Clin Rheumatol. 2014 Sep;33(9):1331-4 - PubMed
  13. J Nutr. 2014 Dec;144(12):2002-8 - PubMed
  14. Clin Orthop Relat Res. 2013 Nov;471(11):3556-62 - PubMed
  15. Ann Intern Med. 1996 Sep 1;125(5):353-9 - PubMed
  16. JAMA. 2013 Jan 9;309(2):155-62 - PubMed
  17. Arthritis Rheum. 2007 Jan;56(1):129-36 - PubMed
  18. J Orthop Sports Phys Ther. 1998 Aug;28(2):88-96 - PubMed
  19. Nat Rev Drug Discov. 2005 Apr;4(4):331-44 - PubMed
  20. Med Princ Pract. 2012;21(1):74-8 - PubMed
  21. Am J Clin Nutr. 2004 Sep;80(3):752-8 - PubMed
  22. Arthritis Rheum. 2009 May;60(5):1381-9 - PubMed
  23. Orthop J Sports Med. 2017 Jun 20;5(6):2325967117711376 - PubMed
  24. J Clin Rheumatol. 2009 Aug;15(5):230-7 - PubMed
  25. Ann Rheum Dis. 2014 Jul;73(7):1323-30 - PubMed

Publication Types