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García-Dios D, Díaz P, Viña M, et al. Efficacy of Oxyclozanide and Closantel against Rumen Flukes (Paramphistomidae) in Naturally Infected Sheep. Animals (Basel). 2020;10(11)doi: 10.3390/ani10111943.
García-Dios, D., Díaz, P., Viña, M., Remesar, S., Prieto, A., López-Lorenzo, G., Cao, J. M. D., Panadero, R., Díez-Baños, P., & López, C. M. (2020). Efficacy of Oxyclozanide and Closantel against Rumen Flukes (Paramphistomidae) in Naturally Infected Sheep. Animals : an open access journal from MDPI, 10(11), . https://doi.org/10.3390/ani10111943
García-Dios, David, et al. "Efficacy of Oxyclozanide and Closantel against Rumen Flukes (Paramphistomidae) in Naturally Infected Sheep." Animals : an open access journal from MDPI vol. 10,11 (2020). doi: https://doi.org/10.3390/ani10111943
García-Dios D, Díaz P, Viña M, Remesar S, Prieto A, López-Lorenzo G, Cao JMD, Panadero R, Díez-Baños P, López CM. Efficacy of Oxyclozanide and Closantel against Rumen Flukes (Paramphistomidae) in Naturally Infected Sheep. Animals (Basel). 2020 Oct 22;10(11). doi: 10.3390/ani10111943. PMID: 33105640; PMCID: PMC7690378.
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Animals (Basel). 2020 Oct 22;10(11). doi: 10.3390/ani10111943.

Efficacy of Oxyclozanide and Closantel against Rumen Flukes (Paramphistomidae) in Naturally Infected Sheep.

Animals : an open access journal from MDPI

David García-Dios, Pablo Díaz, Miguel Viña, Susana Remesar, Alberto Prieto, Gonzalo López-Lorenzo, Jose Manuel Díaz Cao, Rosario Panadero, Pablo Díez-Baños, Ceferino Manuel López

Affiliations

  1. Investigación en Sanidad Animal: Galicia (Grupo INVESAGA), Department of Animal Pathology, Faculty of Veterinary Medicine (Universidade de Santiago de Compostela), 27002 Lugo, Spain.

PMID: 33105640 PMCID: PMC7690378 DOI: 10.3390/ani10111943

Abstract

Paramphistomosis is considered an emergent disease of ruminants in Europe. Some drugs have been found effective for treating paramphistomid infections in cattle, but data in sheep are currently limited. Thus, faecal samples from 25 adult sheep naturally infected with paramphistomids were collected weekly to test the efficacy of oxyclozanide and closantel. Three groups were performed: nine animals orally treated with a single dose of oxyclozanide (15 mg/kg bodyweight (BW) integrated the G-OXI group, whereas eight sheep orally treated with a single dose of closantel (10 mg/kg BW) were placed in a group called G-CLS. Eight untreated controls constituted the group G-CON. Oxyclozanide showed efficacies up to 90% until week 11 post-treatment, with a maximum efficacy of 98.3%, and significant differences were found between G-OXI and G-CON until the 26th week post-treatment. Closantel was insufficiently active (0-81%) throughout the study and differences compared to G-CON were never found. The present study reveals that oxyclozanide given at a single oral dose of 15 mg/kg BW is highly effective against adult rumen flukes in sheep. In addition, the use of a single oral dose of closantel at 10 mg/kg BW is not recommended for treating paramphistomid infections in sheep.

Keywords: closantel; efficacy; oxyclozanide; paramphistomidae; sheep

References

  1. Vet Parasitol. 2003 Oct 20;116(3):217-22 - PubMed
  2. Int J Parasitol. 1991 Nov;21(7):813-9 - PubMed
  3. Vet Parasitol. 2004 Jun 10;122(1):15-26 - PubMed
  4. Vet Parasitol. 2014 Aug 29;204(3-4):199-208 - PubMed
  5. Vet Parasitol. 2000 Jan;87(2-3):133-8 - PubMed
  6. J Anim Sci. 2017 Jan;95(1):103-112 - PubMed
  7. Vet Parasitol. 2013 Jul 1;195(1-2):65-71 - PubMed
  8. Aust Vet J. 1987 Nov;64(11):328-32 - PubMed
  9. Vet Res. 2002 Sep-Oct;33(5):439-47 - PubMed
  10. Vet Parasitol. 2013 Jan 31;191(3-4):252-63 - PubMed
  11. Vet Parasitol. 2014 Aug 29;204(3-4):81-6 - PubMed
  12. Parasitol Res. 2014 Nov;113(11):4097-103 - PubMed
  13. Parasitol Res. 2007 Jul;101(2):339-42 - PubMed
  14. Vet Parasitol. 2006 Sep 10;140(3-4):281-8 - PubMed
  15. Vet J. 2009 May;180(2):265-7 - PubMed
  16. Xenobiotica. 1993 Mar;23(3):285-95 - PubMed
  17. Trop Anim Health Prod. 2007 Feb;39(2):97-102 - PubMed
  18. Vet Parasitol. 2015 Nov 30;214(1-2):178-83 - PubMed
  19. Vet Rec. 2011 Apr 16;168(15):408 - PubMed
  20. Vet Parasitol. 2012 Oct 26;189(2-4):366-8 - PubMed
  21. Aust Vet J. 1993 Jul;70(7):265-6 - PubMed
  22. Vet Parasitol. 2001 Apr 2;96(3):171-93 - PubMed
  23. Vet Parasitol. 2014 Dec 15;206(3-4):277-81 - PubMed
  24. Aust Vet J. 1969 Mar;45(3):133-5 - PubMed
  25. Vet Parasitol. 2013 Jan 16;191(1-2):165-71 - PubMed
  26. Biom J. 2008 Jun;50(3):346-63 - PubMed
  27. Trends Parasitol. 2017 Nov;33(11):836-844 - PubMed
  28. Onderstepoort J Vet Res. 1967 Dec;34(2):451-540 - PubMed
  29. Parasit Vectors. 2015 Dec 23;8:656 - PubMed
  30. BMC Vet Res. 2016 Jul 18;12(1):143 - PubMed
  31. Vet Rec. 2012 Nov 17;171(20):509-10 - PubMed
  32. Vet Parasitol. 2013 Oct 18;197(1-2):126-9 - PubMed
  33. Parasitology. 2017 Feb;144(2):237-247 - PubMed
  34. Parasitol Res. 2020 Nov 3;: - PubMed
  35. Adv Parasitol. 1971;9:33-72 - PubMed
  36. Vet Parasitol. 2012 Sep 30;189(1):2-7 - PubMed
  37. Vet Rec. 2012 Mar;170(13):343-4 - PubMed
  38. Parasit Vectors. 2016 Nov 29;9(1):610 - PubMed
  39. Vet Parasitol. 2015 Jan 15;207(1-2):134-9 - PubMed
  40. Vet Parasitol. 2015 Sep 15;212(3-4):168-74 - PubMed
  41. Aust Vet J. 1988 May;65(5):148-50 - PubMed

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