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El Sabeh M, Afrin S, Singh B, et al. Uterine Stem Cells and Benign Gynecological Disorders: Role in Pathobiology and Therapeutic Implications. Stem Cell Rev Rep. 2020;17(3):803-820doi: 10.1007/s12015-020-10075-w.
El Sabeh, M., Afrin, S., Singh, B., Miyashita-Ishiwata, M., & Borahay, M. (2021). Uterine Stem Cells and Benign Gynecological Disorders: Role in Pathobiology and Therapeutic Implications. Stem cell reviews and reports, 17(3), 803-820. https://doi.org/10.1007/s12015-020-10075-w
El Sabeh, Malak, et al. "Uterine Stem Cells and Benign Gynecological Disorders: Role in Pathobiology and Therapeutic Implications." Stem cell reviews and reports vol. 17,3 (2021): 803-820. doi: https://doi.org/10.1007/s12015-020-10075-w
El Sabeh M, Afrin S, Singh B, Miyashita-Ishiwata M, Borahay M. Uterine Stem Cells and Benign Gynecological Disorders: Role in Pathobiology and Therapeutic Implications. Stem Cell Rev Rep. 2021 Jun;17(3):803-820. doi: 10.1007/s12015-020-10075-w. Epub 2020 Nov 05. PMID: 33155150; PMCID: PMC8096869.
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Stem Cell Rev Rep. 2021 Jun;17(3):803-820. doi: 10.1007/s12015-020-10075-w. Epub 2020 Nov 05.

Uterine Stem Cells and Benign Gynecological Disorders: Role in Pathobiology and Therapeutic Implications.

Stem cell reviews and reports

Malak El Sabeh, Sadia Afrin, Bhuchitra Singh, Mariko Miyashita-Ishiwata, Mostafa Borahay

Affiliations

  1. Department of Gynecology & Obstetrics, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD, 21205, USA.
  2. Department of Gynecology & Obstetrics, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD, 21205, USA. [email protected].

PMID: 33155150 PMCID: PMC8096869 DOI: 10.1007/s12015-020-10075-w

Abstract

Stem cells in the endometrium and myometrium possess an immense regenerative potential which is necessary to maintain the menstrual cycle and support pregnancy. These cells, as well as bone marrow stem cells, have also been implicated in the development of common benign gynecological disorders including leiomyomas, endometriosis and adenomyosis. Current evidence suggests the conversion of uterine stem cells to tumor initiating stem cells in leiomyomas, endometriosis stem cells, and adenomyosis stem cells, acquiring genetic and epigenetic alterations for the progression of each benign condition. In this comprehensive review, we aim to summarize the progress that has been made to characterize the involvement of stem cells in the pathogenesis of benign gynecologic conditions which, despite their enormous burden, are not yet fully understood. We focus on the stem cell characteristics and aberrations that contribute to the development of benign gynecological disorders and the possible clinical implications of what is known so far. Lastly, we discuss the role of uterine stem cells in the setting of regenerative medicine, particularly in the treatment of Asherman syndrome.Graphical abstract.

Keywords: Adenomyosis; Endometriosis; Leiomyoma; Uterine stem cells

References

  1. PLoS One. 2010 Jun 24;5(6):e10964 - PubMed
  2. Med Sci Monit. 2012 Jun;18(6):CR361-7 - PubMed
  3. Cell J. 2017 Apr-Jun;19(1):50-64 - PubMed
  4. J Clin Endocrinol Metab. 2015 Apr;100(4):E601-6 - PubMed
  5. Eur Rev Med Pharmacol Sci. 2016 Aug;20(16):3319-26 - PubMed
  6. Science. 2000 Feb 25;287(5457):1427-30 - PubMed
  7. Am J Obstet Gynecol. 1970 Aug 15;107(8):1168-73 - PubMed
  8. Hum Reprod Update. 2015 Jan-Feb;21(1):1-12 - PubMed
  9. Endocrinology. 2012 Nov;153(11):5566-74 - PubMed
  10. Mol Med. 2009 Nov-Dec;15(11-12):392-401 - PubMed
  11. Hum Reprod Update. 2011 Sep-Oct;17(5):637-53 - PubMed
  12. Hum Reprod. 2007 May;22(5):1214-23 - PubMed
  13. Cochrane Database Syst Rev. 2016 Apr 20;4:CD012165 - PubMed
  14. Hum Reprod. 2010 Aug;25(8):2059-67 - PubMed
  15. Cell Biol Int. 2014 May;38(5):615-24 - PubMed
  16. Lab Invest. 2004 Dec;84(12):1666-76 - PubMed
  17. Hum Reprod. 2017 Nov 1;32(11):2254-2268 - PubMed
  18. J Reprod Med. 1991 Jul;36(7):470-2 - PubMed
  19. Int J Reprod Biomed. 2019 Jan 28;16(12): - PubMed
  20. Stem Cells. 2008 Jul;26(7):1695-704 - PubMed
  21. Obstet Gynecol Clin North Am. 1989 Mar;16(1):221-35 - PubMed
  22. Mol Med. 2015 Apr 13;21:242-56 - PubMed
  23. PLoS One. 2015 Apr 13;10(4):e0120137 - PubMed
  24. PLoS One. 2012;7(5):e36935 - PubMed
  25. Biol Reprod. 2004 Jun;70(6):1738-50 - PubMed
  26. Dev Cell. 2009 Jul;17(1):9-26 - PubMed
  27. PLoS One. 2010 Aug 24;5(8):e12362 - PubMed
  28. Reprod Sci. 2021 Jan;28(1):278-290 - PubMed
  29. Fertil Steril. 2020 Dec;114(6):1339-1349 - PubMed
  30. Cancer Genet Cytogenet. 2010 Oct 1;202(1):11-6 - PubMed
  31. Cells. 2020 Jun 12;9(6): - PubMed
  32. Cell. 2004 Mar 19;116(6):769-78 - PubMed
  33. Nat Med. 2006 Mar;12(3):296-300 - PubMed
  34. Stem Cells. 2014 Jun;32(6):1380-9 - PubMed
  35. Cell. 2001 May 4;105(3):369-77 - PubMed
  36. J Zhejiang Univ Sci B. 2013 Nov;14(11):961-72 - PubMed
  37. Am J Obstet Gynecol. 2015 Aug;213(2):196.e1-8 - PubMed
  38. Fertil Steril. 2000 May;73(5):1006-11 - PubMed
  39. J Clin Endocrinol Metab. 2018 May 1;103(5):1842-1849 - PubMed
  40. Fertil Steril. 2012 Sep;98(3):741-751.e6 - PubMed
  41. Biomed Pharmacother. 2018 Jun;102:333-343 - PubMed
  42. AJR Am J Roentgenol. 2004 Jun;182(6):1543-6 - PubMed
  43. J Cell Mol Med. 2020 Feb;24(4):2464-2474 - PubMed
  44. Stem Cells. 2006 Jan;24(1):3-12 - PubMed
  45. Mol Ther. 2011 Nov;19(11):2065-71 - PubMed
  46. J Ovarian Res. 2017 Apr 24;10(1):29 - PubMed
  47. Reprod Sci. 2010 Feb;17(2):158-67 - PubMed
  48. Cell Stem Cell. 2010 Aug 6;7(2):150-61 - PubMed
  49. Hum Reprod. 2020 Jan 1;35(1):44-57 - PubMed
  50. Nature. 1981 Jul 9;292(5819):154-6 - PubMed
  51. Hum Reprod. 2007 Nov;22(11):2903-11 - PubMed
  52. Front Immunol. 2014 May 19;5:205 - PubMed
  53. Eur J Hum Genet. 2013 Nov;21(11):1300-3 - PubMed
  54. J Clin Endocrinol Metab. 2017 May 1;102(5):1588-1595 - PubMed
  55. Cell J. 2019 Jul;21(2):179-185 - PubMed
  56. Endocrinology. 2014 Apr;155(4):1489-97 - PubMed
  57. Stem Cell Res Ther. 2018 Jul 11;9(1):192 - PubMed
  58. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17053-8 - PubMed
  59. Fertil Steril. 2015 Jul;104(1):225-34.e3 - PubMed
  60. J Hum Reprod Sci. 2011 Jan;4(1):43-8 - PubMed
  61. Am J Pathol. 2018 Oct;188(10):2293-2306 - PubMed
  62. Biol Reprod. 2009 Jun;80(6):1136-45 - PubMed
  63. Fertil Steril. 2011 Mar 1;95(3):1171-3 - PubMed
  64. Gynecol Obstet Res. 2016 Dec;3(2):e1-e4 - PubMed
  65. Fertil Steril. 2017 Mar;107(3):523-532 - PubMed
  66. JAMA. 2004 Jul 7;292(1):81-5 - PubMed
  67. Cell Transplant. 2012;21(10):2201-14 - PubMed
  68. Best Pract Res Clin Obstet Gynaecol. 2006 Aug;20(4):547-55 - PubMed
  69. Reprod Sci. 2020 Sep;27(9):1724-1730 - PubMed
  70. Fertil Steril. 2010 Nov;94(6):1972-9, 1979.e1-4 - PubMed
  71. Eur J Obstet Gynecol Reprod Biol. 2014 Feb;173:88-93 - PubMed
  72. Fertil Steril. 2008 Oct;90(4 Suppl):1528-37 - PubMed
  73. J Clin Med Res. 2013 Jun;5(3):153-63 - PubMed
  74. Cell Stem Cell. 2011 Feb 4;8(2):136-47 - PubMed
  75. PLoS One. 2012;7(8):e44300 - PubMed
  76. J Ovarian Res. 2018 Sep 21;11(1):83 - PubMed
  77. Semin Reprod Med. 2015 Sep;33(5):350-6 - PubMed
  78. Stem Cell Res Ther. 2015 Mar 17;6:32 - PubMed
  79. PLoS One. 2012;7(12):e50749 - PubMed
  80. Fertil Steril. 2011 Jan;95(1):338-41 - PubMed
  81. Fertil Steril. 2018 Dec;110(7):1398-1407.e1 - PubMed
  82. Bull Exp Biol Med. 2008 Apr;145(4):539-43 - PubMed
  83. Trends Neurosci. 2003 Mar;26(3):125-31 - PubMed
  84. Int J Womens Health. 2019 Mar 20;11:191-198 - PubMed
  85. Mol Hum Reprod. 2013 Jul;19(7):407-14 - PubMed
  86. J Pathol. 2014 Feb;232(3):330-43 - PubMed
  87. In Vitro Cell Dev Biol Anim. 2015 Apr;51(4):408-14 - PubMed
  88. Fertil Steril. 2018 Mar;109(3):371-379 - PubMed
  89. Stem Cells Int. 2017;2017:4794827 - PubMed
  90. Reprod Biol Endocrinol. 2013 Dec 27;11:118 - PubMed
  91. Stem Cells. 2007 Aug;25(8):2082-6 - PubMed
  92. PLoS One. 2012;7(3):e33284 - PubMed
  93. Biol Reprod. 2016 May;94(5):118 - PubMed
  94. Stem Cells Dev. 2012 Dec 10;21(18):3324-31 - PubMed
  95. Stem Cells Int. 2018 May 13;2018:1716246 - PubMed
  96. Stem Cells. 2018 Jan;36(1):91-102 - PubMed
  97. Hum Reprod. 2013 Oct;28(10):2695-708 - PubMed
  98. Curr Top Dev Biol. 2005;68:85-122 - PubMed
  99. Reprod Sci. 2017 Sep;24(9):1235-1244 - PubMed
  100. BJU Int. 2013 Oct;112(6):854-63 - PubMed
  101. Cell Commun Signal. 2019 May 17;17(1):45 - PubMed
  102. Reprod Sci. 2021 Feb;28(2):426-434 - PubMed
  103. Biol Reprod. 2012 Feb 29;86(2):58 - PubMed
  104. N Engl J Med. 2013 Oct 3;369(14):1344-55 - PubMed
  105. Am J Obstet Gynecol. 2009 Dec;201(6):608.e1-8 - PubMed
  106. Hum Reprod Update. 2014 Mar-Apr;20(2):262-78 - PubMed
  107. J Assist Reprod Genet. 2014 Aug;31(8):975-82 - PubMed
  108. Reprod Sci. 2019 May;26(5):619-638 - PubMed
  109. Kidney Int Suppl (2011). 2011 Sep;1(3):63-67 - PubMed
  110. Contracept Reprod Med. 2016 Jul 20;1:12 - PubMed
  111. Dev Biol. 2005 Dec 1;288(1):276-83 - PubMed
  112. Lab Invest. 2018 Apr;98(4):439-448 - PubMed
  113. Hum Reprod. 2019 Jan 01;34(1):56-68 - PubMed
  114. Biosci Rep. 2016 Aug 05;36(4): - PubMed
  115. Semin Reprod Med. 2017 Nov;35(6):549-559 - PubMed
  116. Endocrinology. 2020 Oct 1;161(10): - PubMed
  117. Reprod Sci. 2017 Apr;24(4):526-533 - PubMed
  118. J Transl Med. 2007 Nov 15;5:57 - PubMed
  119. Hum Reprod. 2008 Jan;23(1):139-43 - PubMed
  120. JSLS. 2012 Jan-Mar;16(1):140-2 - PubMed
  121. Int J Cancer. 2012 Oct 1;131(7):1528-36 - PubMed
  122. J Cell Mol Med. 2018 Mar;22(3):1627-1639 - PubMed
  123. Biomed Res Int. 2013;2013:901821 - PubMed
  124. Cell Transplant. 2008;17(3):303-11 - PubMed
  125. Ann N Y Acad Sci. 2011 Mar;1221:10-7 - PubMed
  126. Biochem Biophys Res Commun. 2020 Sep 17;530(2):381-388 - PubMed
  127. Fertil Steril. 2009 May;91(5 Suppl):2193-8 - PubMed
  128. J Reprod Immunol. 2016 Aug;116:1-6 - PubMed
  129. Genes Chromosomes Cancer. 2009 Oct;48(10):865-85 - PubMed
  130. Obstet Gynecol Annu. 1974;3(0):425-41 - PubMed
  131. Reprod Sci. 2018 Jun;25(6):802-817 - PubMed
  132. Biol Reprod. 2009 Sep;81(3):545-52 - PubMed
  133. Stem Cells. 2017 Mar;35(3):666-678 - PubMed
  134. Reprod Biol Endocrinol. 2015 Sep 29;13:110 - PubMed
  135. Hum Reprod Update. 2016 Dec;23(1):41-76 - PubMed
  136. Biol Reprod. 2015 Aug;93(2):37 - PubMed
  137. Am J Obstet Gynecol. 2016 Dec;215(6):750.e1-750.e8 - PubMed
  138. J Hum Reprod Sci. 2014 Apr;7(2):93-8 - PubMed
  139. Am J Obstet Gynecol. 2020 Nov;223(5):733.e1-733.e14 - PubMed
  140. Am Surg. 1985 Jul;51(7):426-30 - PubMed
  141. Reproduction. 2010 Jan;139(1):247-53 - PubMed
  142. Stem Cell Res Ther. 2018 Nov 29;9(1):333 - PubMed
  143. Reprod Sci. 2014 Dec;21(12):1465-71 - PubMed
  144. PLoS One. 2012;7(3):e33251 - PubMed
  145. Reprod Sci. 2011 Aug;18(8):755-62 - PubMed
  146. Hum Reprod. 2016 May;31(5):1087-96 - PubMed
  147. Sci Rep. 2014 Apr 08;4:4599 - PubMed
  148. Hum Reprod Update. 2018 Mar 1;24(2):207-224 - PubMed
  149. Science. 2005 Jun 10;308(5728):1589-92 - PubMed
  150. Hum Reprod. 2001 Nov;16(11):2427-33 - PubMed
  151. Obstet Gynecol Clin North Am. 1997 Jun;24(2):235-58 - PubMed
  152. J Pharmacol Exp Ther. 2010 Dec;335(3):817-29 - PubMed
  153. Fertil Steril. 2012 Sep;98(3):511-9 - PubMed
  154. Am J Physiol Cell Physiol. 2015 Oct 15;309(8):C522-31 - PubMed
  155. J Biol Chem. 2014 Dec 19;289(51):35075-86 - PubMed
  156. Eur J Obstet Gynecol Reprod Biol. 2003 Dec 10;111(2):197-203 - PubMed
  157. Fertil Steril. 2011 Mar 15;95(4):1308-15.e1 - PubMed
  158. N Engl J Med. 2009 Jan 15;360(3):268-79 - PubMed
  159. Hum Reprod Update. 2007 Jan-Feb;13(1):87-101 - PubMed
  160. Hum Reprod Update. 2016 Mar-Apr;22(2):137-63 - PubMed
  161. Acta Obstet Gynecol Scand. 2019 Dec;98(12):1565-1574 - PubMed
  162. Oncogene. 2019 Apr;38(15):2722-2735 - PubMed
  163. Mol Hum Reprod. 2009 Apr;15(4):259-67 - PubMed
  164. Cell Physiol Biochem. 2018;49(5):1970-1986 - PubMed
  165. J Reprod Immunol. 2014 Jun;103:45-52 - PubMed
  166. Mol Cancer Ther. 2011 Dec;10(12):2276-86 - PubMed
  167. Stem Cell Res Ther. 2018 Jun 28;9(1):175 - PubMed
  168. Stem Cells. 2009 Mar;27(3):577-605 - PubMed
  169. Int J Med Sci. 2018 Sep 7;15(12):1406-1414 - PubMed
  170. Fertil Steril. 2015 Dec;104(6):1475-83.e1-3 - PubMed
  171. Fertil Steril. 2014 Sep;102(3):621-9 - PubMed
  172. Leukemia. 2014 Mar;28(3):473-84 - PubMed
  173. PLoS One. 2014 May 12;9(5):e96662 - PubMed
  174. PLoS One. 2010 Apr 28;5(4):e10387 - PubMed
  175. Mol Med Rep. 2017 Dec;16(6):8259-8264 - PubMed
  176. Am J Obstet Gynecol. 2012 Aug;207(2):114.e1-7 - PubMed
  177. Hum Reprod Update. 1998 Jul-Aug;4(4):312-22 - PubMed
  178. Fertil Steril. 2008 Apr;89(4):759-79 - PubMed
  179. J Tissue Eng Regen Med. 2015 Nov;9(11):1268-76 - PubMed
  180. Best Pract Res Clin Obstet Gynaecol. 2008 Aug;22(4):571-88 - PubMed
  181. Hum Reprod. 2002 Oct;17(10):2725-36 - PubMed
  182. EXCLI J. 2017 Jun 14;16:852-867 - PubMed
  183. Semin Reprod Med. 2017 Nov;35(6):481-486 - PubMed
  184. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18700-5 - PubMed
  185. J Cell Mol Med. 2011 Apr;15(4):747-55 - PubMed
  186. Fertil Steril. 2016 Jun;105(6):1638-1648.e8 - PubMed
  187. Mol Hum Reprod. 2015 Apr;21(4):330-8 - PubMed
  188. Reprod Biomed Online. 2017 Nov;35(5):592-601 - PubMed
  189. Am J Reprod Immunol. 2017 Nov;78(5): - PubMed
  190. Hum Reprod. 2008 Jul;23(7):1511-9 - PubMed
  191. Stem Cell Res. 2015 Jul;15(1):14-22 - PubMed
  192. Reprod Biomed Online. 2018 Mar;36(3):294-301 - PubMed
  193. Hum Reprod. 2016 Dec;31(12):2723-2729 - PubMed
  194. Endocr Rev. 2006 Feb;27(1):17-46 - PubMed
  195. Obstet Gynecol Surv. 2019 Nov;74(11):661-673 - PubMed
  196. Fertil Steril. 2007 Apr;87(4):725-36 - PubMed

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