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Paramonova MP, Khandazhinskaya AL, Ozerov AA, et al. Synthesis and Antiviral Properties of 1-Substituted 3-[ω-(4-Oxoquinazolin-4(3H)-yl)alkyl]uracil Derivatives. Acta Naturae. 2020;12(3):134-139doi: 10.32607/actanaturae.10983.
Paramonova, M. P., Khandazhinskaya, A. L., Ozerov, A. A., Kochetkov, S. N., Snoeck, R., Andrei, G., & Novikov, M. S. (2020). Synthesis and Antiviral Properties of 1-Substituted 3-[ω-(4-Oxoquinazolin-4(3H)-yl)alkyl]uracil Derivatives. Acta naturae, 12(3), 134-139. https://doi.org/10.32607/actanaturae.10983
Paramonova, M P, et al. "Synthesis and Antiviral Properties of 1-Substituted 3-[ω-(4-Oxoquinazolin-4(3H)-yl)alkyl]uracil Derivatives." Acta naturae vol. 12,3 (2020): 134-139. doi: https://doi.org/10.32607/actanaturae.10983
Paramonova MP, Khandazhinskaya AL, Ozerov AA, Kochetkov SN, Snoeck R, Andrei G, Novikov MS. Synthesis and Antiviral Properties of 1-Substituted 3-[ω-(4-Oxoquinazolin-4(3H)-yl)alkyl]uracil Derivatives. Acta Naturae. 2020 Jul-Sep;12(3):134-139. doi: 10.32607/actanaturae.10983. PMID: 33173603; PMCID: PMC7604896.
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Acta Naturae. 2020 Jul-Sep;12(3):134-139. doi: 10.32607/actanaturae.10983.

Synthesis and Antiviral Properties of 1-Substituted 3-[ω-(4-Oxoquinazolin-4(3H)-yl)alkyl]uracil Derivatives.

Acta naturae

M P Paramonova, A L Khandazhinskaya, A A Ozerov, S N Kochetkov, R Snoeck, G Andrei, M S Novikov

Affiliations

  1. Department of Pharmaceutical & Toxicological Chemistry, Volgograd State Medical University, Volgograd, 400131 Russia.
  2. Engelhardt Institute of Molecular Biology, Russian Academy of Science, Moscow, 119991 Russia.
  3. Rega Institute for Medical Research, KU Leuven, B-3000 Leuven, Belgium.

PMID: 33173603 PMCID: PMC7604896 DOI: 10.32607/actanaturae.10983

Abstract

A series of uracil derivatives containing a 4-oxoquinazoline fragment bound to the nitrogen atom N3 of the pyrimidine ring by a short methylene bridge was synthesized to search for new antiviral agents. Some compounds in this series are shown to exhibit high inhibitory activity against human cytomegalovirus and the varicella zoster virus in a HEL cell culture.

Copyright ® 2020 National Research University Higher School of Economics.

Keywords: 4-oxoquinazoline; antiviral activity; human cytomegalovirus; synthesis; uracil derivatives; varicella zoster virus

References

  1. Sci Rep. 2016 Jul 12;6:29487 - PubMed
  2. Infect Disord Drug Targets. 2011 Oct;11(5):475-503 - PubMed
  3. Lancet. 2000 Aug 19;356(9230):645-9 - PubMed
  4. World J Gastroenterol. 2016 Feb 14;22(6):2030-45 - PubMed
  5. Bioorg Med Chem. 2013 Jul 15;21(14):4151-7 - PubMed
  6. J Pathol. 2015 Jan;235(2):288-97 - PubMed
  7. Circulation. 2004 Feb 3;109(4):500-5 - PubMed
  8. J Infect Dis. 2016 Oct 1;214 Suppl 2:S67-74 - PubMed
  9. J Infect Dis. 2011 Jun 1;203(11):1510-2 - PubMed
  10. Expert Opin Pharmacother. 2019 Aug;20(12):1429-1438 - PubMed
  11. J Infect Dis. 2015 Jan 15;211(2):178-86 - PubMed
  12. Mech Ageing Dev. 2016 Sep;158:46-52 - PubMed
  13. Antimicrob Agents Chemother. 1999 Mar;43(3):557-67 - PubMed
  14. J Infect Dis. 2003 Mar 1;187(5):777-84 - PubMed
  15. Antiviral Res. 2019 Mar;163:91-105 - PubMed
  16. Arch Ophthalmol. 1998 Feb;116(2):178-85 - PubMed
  17. J Infect Dis. 1999 Sep;180(3):702-7 - PubMed
  18. Bioorg Med Chem. 2015 Nov 1;23(21):7035-44 - PubMed
  19. Diagn Cytopathol. 2018 Jul;46(7):593-599 - PubMed
  20. Transpl Int. 2015 Dec;28(12):1351-6 - PubMed
  21. J Virol Methods. 1988 Sep;21(1-4):79-86 - PubMed

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