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Phinius BB, Anderson M, Bhebhe L, et al. Increased Prevalence of Liver Fibrosis and HIV Viremia among Patients with HIV, HBV, and Tuberculosis in Botswana. Pathogens. 2020;9(11)doi: 10.3390/pathogens9110950.
Phinius, B. B., Anderson, M., Bhebhe, L., Baruti, K., Manowe, G., Choga, W. T., Mupfumi, L., Mbangiwa, T., Mudanga, M., Moyo, S., Marlink, R., Blackard, J. T., & Gaseitsiwe, S. (2020). Increased Prevalence of Liver Fibrosis and HIV Viremia among Patients with HIV, HBV, and Tuberculosis in Botswana. Pathogens (Basel, Switzerland), 9(11), . https://doi.org/10.3390/pathogens9110950
Phinius, Bonolo B, et al. "Increased Prevalence of Liver Fibrosis and HIV Viremia among Patients with HIV, HBV, and Tuberculosis in Botswana." Pathogens (Basel, Switzerland) vol. 9,11 (2020). doi: https://doi.org/10.3390/pathogens9110950
Phinius BB, Anderson M, Bhebhe L, Baruti K, Manowe G, Choga WT, Mupfumi L, Mbangiwa T, Mudanga M, Moyo S, Marlink R, Blackard JT, Gaseitsiwe S. Increased Prevalence of Liver Fibrosis and HIV Viremia among Patients with HIV, HBV, and Tuberculosis in Botswana. Pathogens. 2020 Nov 14;9(11). doi: 10.3390/pathogens9110950. PMID: 33202597; PMCID: PMC7696587.
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Pathogens. 2020 Nov 14;9(11). doi: 10.3390/pathogens9110950.

Increased Prevalence of Liver Fibrosis and HIV Viremia among Patients with HIV, HBV, and Tuberculosis in Botswana.

Pathogens (Basel, Switzerland)

Bonolo B Phinius, Motswedi Anderson, Lynnette Bhebhe, Kabo Baruti, Godiraone Manowe, Wonderful T Choga, Lucy Mupfumi, Tshepiso Mbangiwa, Mbatshi Mudanga, Sikhulile Moyo, Richard Marlink, Jason T Blackard, Simani Gaseitsiwe

Affiliations

  1. Research Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.
  2. Department of Biological Sciences, Faculty of Sciences, University of Botswana, Gaborone 0000, Botswana.
  3. Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.
  4. Department of Statistics, Faculty of Sciences, University of Botswana, Gaborone 0000, Botswana.
  5. Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  6. Rutgers Global Health Institute, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ 08901, USA.
  7. Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.

PMID: 33202597 PMCID: PMC7696587 DOI: 10.3390/pathogens9110950

Abstract

People with concomitant human immunodeficiency virus (HIV) and tuberculosis (TB) have an increased risk of hepatotoxic reactions due to antiretroviral therapy (ART) and anti-TB therapy (ATT). Concomitant hepatitis B virus (HBV) in these patients may lead to poorer health outcomes. To assess liver enzyme levels and immune response in adults with HIV, HBV, and TB, data from 300 antiretroviral-naïve people living with HIV (PLWHIV) were analyzed. The prevalence of HIV/HBV (cHIV/HBV) and HIV/TB (cHIV/TB) was 28% (95% CI: 23.0-33.4) and 10% (95% CI: 6.8-14.0), respectively. HIV/HBV/TB (cHIV/HBV/TB) prevalence was 5.3% (95% CI: 3.1-8.5). There was a statistically significant difference between the groups of participants in HIV viral load (

Keywords: Africa; Botswana; hepatitis B virus; human immunodeficiency virus; tuberculosis

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