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Hashem HE, Abdel Halim RM, El Masry SA, et al. The Utility of Neutrophil CD64 and Presepsin as Diagnostic, Prognostic, and Monitoring Biomarkers in Neonatal Sepsis. Int J Microbiol. 2020;2020:8814892doi: 10.1155/2020/8814892.
Hashem, H. E., Abdel Halim, R. M., El Masry, S. A., Mokhtar, A. M., & Abdelaal, N. M. (2020). The Utility of Neutrophil CD64 and Presepsin as Diagnostic, Prognostic, and Monitoring Biomarkers in Neonatal Sepsis. International journal of microbiology, 20208814892. https://doi.org/10.1155/2020/8814892
Hashem, Heba E, et al. "The Utility of Neutrophil CD64 and Presepsin as Diagnostic, Prognostic, and Monitoring Biomarkers in Neonatal Sepsis." International journal of microbiology vol. 2020 (2020): 8814892. doi: https://doi.org/10.1155/2020/8814892
Hashem HE, Abdel Halim RM, El Masry SA, Mokhtar AM, Abdelaal NM. The Utility of Neutrophil CD64 and Presepsin as Diagnostic, Prognostic, and Monitoring Biomarkers in Neonatal Sepsis. Int J Microbiol. 2020 Nov 01;2020:8814892. doi: 10.1155/2020/8814892. eCollection 2020. PMID: 33204274; PMCID: PMC7654214.
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Int J Microbiol. 2020 Nov 01;2020:8814892. doi: 10.1155/2020/8814892. eCollection 2020.

The Utility of Neutrophil CD64 and Presepsin as Diagnostic, Prognostic, and Monitoring Biomarkers in Neonatal Sepsis.

International journal of microbiology

Heba E Hashem, Rania M Abdel Halim, Sherin A El Masry, Amira M Mokhtar, Noureldin M Abdelaal

Affiliations

  1. Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  2. Pediatric and Neonatology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

PMID: 33204274 PMCID: PMC7654214 DOI: 10.1155/2020/8814892

Abstract

BACKGROUND: Neonatal septicemia is a critical medical situation; current conventional laboratory methods still have many limitations and diagnostic obstacles. For this purpose, last decades have witnessed a challenge between the battery of sepsis biomarkers including many leukocyte surface antigens, not only for early diagnostic purposes but also for better follow-up and good management of sepsis patients.

AIM: To evaluate the diagnostic, prognostic, and monitoring performance of both neutrophil CD64 (nCD64) and presepsin as sepsis biomarkers compared to each other and to the conventional laboratory sepsis parameters aiming to decide which is the best fitting for routine daily use in neonatal intensive care units (NICUs).

METHODS: 235 neonates were enrolled from three Egyptian neonatal ICUs, during the period from November 2015 till March 2018; they were classified into two main groups: the control group (

RESULTS: Significant increase in nCD64 and presepsin values was found in sepsis groups compared to the controls. At cutoff 41.6%, nCD64% could discriminate the presence of septicemia with sensitivity 94.7%, specificity 93.6 %, and AUC 0.925, while presepsin at cutoff 686 pg/ml achieves sensitivity 82.7%, specificity 95.5%, and AUC 0.887, respectively. Significant increase in nCD64 (

CONCLUSION: nCD64 and presepsin are valuable early diagnostic and monitoring sepsis biomarkers; the highest sensitivity could be achieved by a univariant sepsis marker in this study was recorded by the nCD64% biomarker, while the highest specificity was documented by presepsin. Combined measurement of both achieves the highest diagnostic performance in sepsis neonates. Either of CD64 or presepsin combined with hs-CRP associated with better performance than any of them alone. nCD64 carries an additional promising role in reflecting sepsis prognosis.

Copyright © 2020 Heba E. Hashem et al.

Conflict of interest statement

The authors declare that there are no conflicts of interest.

References

  1. Egypt J Immunol. 2016 Jun;23(2):29-37 - PubMed
  2. BMC Public Health. 2015 Mar 25;15:285 - PubMed
  3. BMC Pediatr. 2009 Jan 19;9:5 - PubMed
  4. J Clin Microbiol. 2009 Dec;47(12):3914-9 - PubMed
  5. BMC Pediatr. 2016 Jul 07;16:82 - PubMed
  6. J Investig Med. 2014 Mar;62(3):644-9 - PubMed
  7. JAMA. 2015 Sep 8;314(10):1039-51 - PubMed
  8. Clin Chim Acta. 2015 Dec 7;451(Pt A):46-64 - PubMed
  9. Ital J Pediatr. 2016 Jun 07;42(1):57 - PubMed
  10. Lancet. 2012 Jun 9;379(9832):2151-61 - PubMed
  11. J Pediatr. 1991 Sep;119(3):417-23 - PubMed
  12. Clin Rheumatol. 2019 May;38(5):1319-1328 - PubMed
  13. Pediatr Int. 2018 May;60(5):428-432 - PubMed
  14. EJIFCC. 2017 May 01;28(2):114-121 - PubMed
  15. Cytokine. 2006 Dec;36(5-6):283-90 - PubMed
  16. Curr Opin Pediatr. 2006 Apr;18(2):125-31 - PubMed
  17. Pediatrics. 2015 Jan;135(1):68-75 - PubMed
  18. Early Hum Dev. 2017 Feb;105:25-33 - PubMed
  19. Indian J Hematol Blood Transfus. 2011 Mar;27(1):14-7 - PubMed
  20. Scand J Infect Dis. 2010 Apr;42(4):299-305 - PubMed
  21. Cytometry A. 2011 Jun;79(6):446-60 - PubMed
  22. Expert Rev Anti Infect Ther. 2016 Oct;14(10):929-41 - PubMed
  23. Biomed Res Int. 2020 Aug 7;2020:6214363 - PubMed
  24. J Matern Fetal Neonatal Med. 2012 Oct;25(Suppl 5):51-3 - PubMed
  25. PLoS One. 2013 Dec 18;8(12):e82700 - PubMed
  26. Curr Opin Pediatr. 2016 Apr;28(2):135-40 - PubMed
  27. Lancet Respir Med. 2018 Mar;6(3):223-230 - PubMed
  28. World J Emerg Med. 2014;5(1):16-9 - PubMed
  29. J Matern Fetal Neonatal Med. 2016;29(11):1834-9 - PubMed
  30. Folia Microbiol (Praha). 2015 Mar;60(2):111-8 - PubMed
  31. Eur J Pediatr. 2018 May;177(5):625-632 - PubMed
  32. AIDS Res Hum Retroviruses. 2017 Feb;33(2):147-156 - PubMed
  33. J Infect. 2016 Jan;72(1):1-18 - PubMed
  34. Am J Respir Crit Care Med. 2012 Jul 1;186(1):65-71 - PubMed
  35. Cytokine. 2014 Feb;65(2):184-91 - PubMed
  36. Clin Chem Lab Med. 2019 Dec 18;58(1):11-17 - PubMed
  37. Egypt J Immunol. 2008;15(2):53-61 - PubMed
  38. Biomed Res Int. 2015;2015:509484 - PubMed
  39. J Infect Chemother. 2012 Dec;18(6):891-7 - PubMed
  40. Egypt J Immunol. 2017 Jan;24(1):29-36 - PubMed
  41. BMC Pediatr. 2010 Jun 04;10:39 - PubMed
  42. J Clin Lab Anal. 2010;24(6):363-70 - PubMed
  43. Ann Clin Lab Sci. 2017 Mar;47(2):184-190 - PubMed
  44. Am J Perinatol. 2017 May;34(6):550-556 - PubMed
  45. J Trop Pediatr. 2015 Feb;61(1):1-13 - PubMed
  46. World J Emerg Med. 2020;11(2):79-86 - PubMed
  47. Neonatology. 2012;102(1):25-36 - PubMed
  48. Ann Saudi Med. 2016 Jan-Feb;36(1):37-41 - PubMed
  49. Arch Dis Child Fetal Neonatal Ed. 2004 May;89(3):F229-35 - PubMed
  50. Int J Pediatr. 2013;2013:763191 - PubMed
  51. Adv Clin Exp Med. 2017 Mar-Apr;26(2):327-332 - PubMed
  52. J Matern Fetal Neonatal Med. 2011 Oct;24 Suppl 2:12-4 - PubMed
  53. Clin Exp Immunol. 2008 Oct;154(1):87-97 - PubMed
  54. Infect Drug Resist. 2019 Jan 29;12:311-319 - PubMed
  55. Clin Biochem. 2020 Mar;77:7-13 - PubMed
  56. BMC Pediatr. 2013 Mar 01;13:31 - PubMed
  57. Bull World Health Organ. 2008 Aug;86(8):650-2 - PubMed
  58. Wien Klin Wochenschr. 2020 Apr;132(7-8):182-187 - PubMed
  59. Korean J Pediatr. 2012 Jan;55(1):11-7 - PubMed
  60. Clin Chim Acta. 2017 Jan;464:6-11 - PubMed
  61. Pediatr Clin North Am. 2013 Apr;60(2):367-89 - PubMed
  62. J Matern Fetal Neonatal Med. 2017 Jul;30(14):1709-1714 - PubMed
  63. Clin Chim Acta. 2016 Sep 1;460:93-101 - PubMed
  64. J Pediatric Infect Dis Soc. 2014 Sep;3(3):234-45 - PubMed
  65. J Int Med Res. 2013 Aug;41(4):934-43 - PubMed
  66. Nat Commun. 2017 Jul 03;8:15949 - PubMed

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