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Abood AA, Møller-Madsen B, Shiguetomi-Medina JM, et al. Autologous cartilage and fibrin sealant may be superior to conventional fat grafting in preventing physeal bone bridge formation - a pilot study in porcines. J Child Orthop. 2020;14(5):459-465doi: 10.1302/1863-2548.14.200024.
Abood, A. A., Møller-Madsen, B., Shiguetomi-Medina, J. M., Stødkilde-Jørgensen, H., Foldager, C., & Rahbek, O. (2020). Autologous cartilage and fibrin sealant may be superior to conventional fat grafting in preventing physeal bone bridge formation - a pilot study in porcines. Journal of children's orthopaedics, 14(5), 459-465. https://doi.org/10.1302/1863-2548.14.200024
Abood, Ahmed A, et al. "Autologous cartilage and fibrin sealant may be superior to conventional fat grafting in preventing physeal bone bridge formation - a pilot study in porcines." Journal of children's orthopaedics vol. 14,5 (2020): 459-465. doi: https://doi.org/10.1302/1863-2548.14.200024
Abood AA, Møller-Madsen B, Shiguetomi-Medina JM, Stødkilde-Jørgensen H, Foldager C, Rahbek O. Autologous cartilage and fibrin sealant may be superior to conventional fat grafting in preventing physeal bone bridge formation - a pilot study in porcines. J Child Orthop. 2020 Oct 01;14(5):459-465. doi: 10.1302/1863-2548.14.200024. PMID: 33204354; PMCID: PMC7666797.
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J Child Orthop. 2020 Oct 01;14(5):459-465. doi: 10.1302/1863-2548.14.200024.

Autologous cartilage and fibrin sealant may be superior to conventional fat grafting in preventing physeal bone bridge formation - a pilot study in porcines.

Journal of children's orthopaedics

Ahmed A Abood, Bjarne Møller-Madsen, Juan Manuel Shiguetomi-Medina, Hans Stødkilde-Jørgensen, Casper Foldager, Ole Rahbek

Affiliations

  1. Department of Orthopaedics, Aarhus University Hospital, Aarhus, Denmark.
  2. MR-center, Aarhus University Hospital, Aarhus, Denmark.
  3. Department of Orthopaedics, Aalborg University Hospital, Aalborg, Denmark.

PMID: 33204354 PMCID: PMC7666797 DOI: 10.1302/1863-2548.14.200024

Abstract

PURPOSE: The article compares physeal recovery after insertion of autologous cartilage and a conventional fat graft in a standardized porcine physeal gap model. Presence of a bone bridge was the primary outcome.

METHODS: Ten porcines in two groups of five were included in a paired design. A standardized physeal gap in the distal femur was made in all animals. One group (n = 5) was randomized for deposition of autologous cartilage and a Tisseel

RESULTS: MRI - Three bone bridges were seen in the fat grafted gaps. All empty gaps formed a bone bridge. No gaps filled with autologous cartilage and Tisseel

CONCLUSIONS: Fat grafts seems ineffective in preventing bone bridges. The use of autologous cartilage may be superior to the current treatment. However, donor site complications were not investigated. The study serves as a proof of concept study and requires further investigation.

LEVEL OF EVIDENCE: III.

Copyright © 2020, The author(s).

Keywords: bone bridges; cartilage graft; fat graft

References

  1. J Orthop Res. 2004 Nov;22(6):1215-21 - PubMed
  2. Cartilage. 2015 Apr;6(2):123-32 - PubMed
  3. Indian J Ophthalmol. 2009 Sep-Oct;57(5):371-9 - PubMed
  4. Nat Med. 2003 Jun;9(6):669-76 - PubMed
  5. J Pediatr Orthop. 1990 Nov-Dec;10(6):713-6 - PubMed
  6. J Pediatr Orthop. 1987 Sep-Oct;7(5):518-23 - PubMed
  7. J Pediatr Orthop. 1996 Mar-Apr;16(2):144-50 - PubMed
  8. J Pediatr Orthop B. 2012 Jul;21(4):369-72 - PubMed
  9. AJR Am J Roentgenol. 2002 Apr;178(4):967-72 - PubMed
  10. Clin Orthop Relat Res. 2002 Dec;(405):242-9 - PubMed
  11. J Pediatr Orthop. 2007 Sep;27(6):703-8 - PubMed
  12. Pediatr Radiol. 2015 Aug;45(9):1403-12 - PubMed
  13. J Bone Joint Surg Br. 1988 Mar;70(2):187-91 - PubMed
  14. J Am Acad Orthop Surg. 2005 Jan-Feb;13(1):47-58 - PubMed
  15. Stem Cells Int. 2011;2011:570125 - PubMed
  16. J Pediatr Orthop B. 2006 Mar;15(2):126-30 - PubMed
  17. J Mol Histol. 2011 Dec;42(6):513-22 - PubMed
  18. Curr Opin Pediatr. 2008 Feb;20(1):46-51 - PubMed
  19. J Orthop Traumatol. 2017 Sep;18(3):217-220 - PubMed
  20. Drug Discov Today. 2003 Nov 1;8(21):980-9 - PubMed
  21. Nat Med. 1999 Jun;5(6):623-8 - PubMed
  22. J Thorac Cardiovasc Surg. 1989 Feb;97(2):194-203 - PubMed

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