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Gorbunova AS, Yapryntseva MA, Denisenko TV, et al. BNIP3 in Lung Cancer: To Kill or Rescue?. Cancers (Basel). 2020;12(11)doi: 10.3390/cancers12113390.
Gorbunova, A. S., Yapryntseva, M. A., Denisenko, T. V., & Zhivotovsky, B. (2020). BNIP3 in Lung Cancer: To Kill or Rescue?. Cancers, 12(11), . https://doi.org/10.3390/cancers12113390
Gorbunova, Anna S, et al. "BNIP3 in Lung Cancer: To Kill or Rescue?." Cancers vol. 12,11 (2020). doi: https://doi.org/10.3390/cancers12113390
Gorbunova AS, Yapryntseva MA, Denisenko TV, Zhivotovsky B. BNIP3 in Lung Cancer: To Kill or Rescue?. Cancers (Basel). 2020 Nov 16;12(11). doi: 10.3390/cancers12113390. PMID: 33207677; PMCID: PMC7697772.
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Cancers (Basel). 2020 Nov 16;12(11). doi: 10.3390/cancers12113390.

BNIP3 in Lung Cancer: To Kill or Rescue?.

Cancers

Anna S Gorbunova, Maria A Yapryntseva, Tatiana V Denisenko, Boris Zhivotovsky

Affiliations

  1. Faculty of Basic Medicine, Lomonosov Moscow State University, 119192 Moscow, Russia.
  2. Karolinska Institutet, Institute of Environmental Medicine, SE-17177 Stockholm, Sweden.

PMID: 33207677 PMCID: PMC7697772 DOI: 10.3390/cancers12113390

Abstract

Bcl-2/adenovirus E1B 19kDa interacting protein 3 (BNIP3) is a pro-apoptotic BH3-only protein of the Bcl-2 family. Initially, BNIP3 was described as one of the mediators of hypoxia-induced apoptotic cell death in cardiac myocytes and neurons. Besides apoptosis, BNIP3 plays a crucial role in autophagy, metabolic pathways, and metastasis-related processes in different tumor types. Lung cancer is one of the most aggressive types of cancer, which is often diagnosed at an advanced stage. Therefore, there is still urgent demand for reliable biochemical markers for lung cancer and its efficient treatment. Mitochondria functioning and mitochondrial proteins, including BNIP3, have a strong impact on lung cancer development and progression. Here, we summarized current knowledge about the BNIP3 gene and protein features and their role in cancer progression, especially in lung cancer in order to develop new therapeutic approaches associated with BNIP3.

Keywords: BNIP3; apoptosis; autophagy; lung cancer; metastasis

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