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Nishina H, Kashimura A, Sakairi T, et al. Spontaneous hyaline glomerulopathy in a young Slc:ICR mouse. J Toxicol Pathol. 2020;33(4):303-307doi: 10.1293/tox.2020-0027.
Nishina, H., Kashimura, A., Sakairi, T., Nishikawa, S., Mizukawa, M., & Sato, H. (2020). Spontaneous hyaline glomerulopathy in a young Slc:ICR mouse. Journal of toxicologic pathology, 33(4), 303-307. https://doi.org/10.1293/tox.2020-0027
Nishina, Hironobu, et al. "Spontaneous hyaline glomerulopathy in a young Slc:ICR mouse." Journal of toxicologic pathology vol. 33,4 (2020): 303-307. doi: https://doi.org/10.1293/tox.2020-0027
Nishina H, Kashimura A, Sakairi T, Nishikawa S, Mizukawa M, Sato H. Spontaneous hyaline glomerulopathy in a young Slc:ICR mouse. J Toxicol Pathol. 2020 Oct;33(4):303-307. doi: 10.1293/tox.2020-0027. Epub 2020 Aug 25. PMID: 33239849; PMCID: PMC7677629.
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J Toxicol Pathol. 2020 Oct;33(4):303-307. doi: 10.1293/tox.2020-0027. Epub 2020 Aug 25.

Spontaneous hyaline glomerulopathy in a young Slc:ICR mouse.

Journal of toxicologic pathology

Hironobu Nishina, Akane Kashimura, Tetsuya Sakairi, Satomi Nishikawa, Mao Mizukawa, Hiroko Sato

Affiliations

  1. Safety Research Laboratories, Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 2-26-1 Muraoka-Higashi, Fujisawa, Kanagawa 251-8555, Japan.

PMID: 33239849 PMCID: PMC7677629 DOI: 10.1293/tox.2020-0027

Abstract

Hyaline glomerulopathy is a type of glomerular lesion that occurs in aging mice. Spontaneous hyaline glomerulopathy is rare in young mice. Here, we report spontaneous hyaline glomerulopathy in a young adult (15-week-old) ICR mouse. Necropsy revealed discoloration and roughness of the kidney surface. Microscopically, diffuse glomerular lesions were prominent. Amorphous, eosinophilic materials were deposited globally in the glomeruli. The mesangial region was expanded; however, the mesangial cells showed no proliferation. Thickening of the Bowman's capsule with proliferation of parietal epithelial cells was observed. Glomerular deposits were strongly positive for anti-IgM, anti-IgG, and periodic acid-Schiff stain and were stained red by Masson's trichrome stain. The deposits were negative for anti C3 and stained negatively with Congo red stain. Periodic acid methenamine silver and electron microscopy revealed glomerular deposits limited to intraglomerular capillaries. Based on the histological features, we diagnosed this lesion as hyaline glomerulopathy. This case could improve our understanding of spontaneous lesions in toxicological and pharmacological studies.

©2020 The Japanese Society of Toxicologic Pathology.

Keywords: ICR mouse; glomerulopathy; hyaline glomerulopathy; immunoglobulin; spontaneous lesion

Conflict of interest statement

The authors declare that there are no conflicts of interest.

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