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Comput Struct Biotechnol J. 2020 Nov 04;18:3324-3334. doi: 10.1016/j.csbj.2020.10.027. eCollection 2020.

The staphylococcal exopolysaccharide PIA - Biosynthesis and role in biofilm formation, colonization, and infection.

Computational and structural biotechnology journal

Hoai T T Nguyen, Thuan H Nguyen, Michael Otto

Affiliations

  1. Pathogen Molecular Genetics Section, Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, U.S. National Institutes of Health, 50 South Drive, Bethesda 20814, MD, USA.
  2. School of Biotechnology, International University, Vietnam National University of Ho Chi Minh City, Khu Pho 6, Thu Duc, Ho Chi Minh City, Viet Nam.

PMID: 33240473 PMCID: PMC7674160 DOI: 10.1016/j.csbj.2020.10.027

Abstract

Exopolysaccharide is a key part of the extracellular matrix that contributes to important mechanisms of bacterial pathogenicity, most notably biofilm formation and immune evasion. In the human pathogens

Keywords: Biofilm; CoNS, coagulase-negative staphylococci; Colonization; Device-related infection; MRSA, methicillin-resistant Staphylococcus aureus; MSSA, methicillin-sensitive Staphylococcus aureus; PIA; PIA, polysaccharide intercellular adhesin; PNAG; PNAG, poly-N-acetylglucosamine; Poly-N-acetylglucosamine; Polysaccharide intercellular adhesin; Staphylococcus aureus; Staphylococcus epidermidis

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

References

  1. Microbiology (Reading). 2011 Apr;157(Pt 4):1042-1049 - PubMed
  2. J Biotechnol. 2000 Sep 29;83(1-2):37-44 - PubMed
  3. Cell Microbiol. 2004 Mar;6(3):269-75 - PubMed
  4. Infect Immun. 2005 Mar;73(3):1811-9 - PubMed
  5. Infect Immun. 1998 Oct;66(10):4711-20 - PubMed
  6. Microb Pathog. 2004 May;36(5):237-45 - PubMed
  7. J Orthop Res. 2017 Feb;35(2):381-388 - PubMed
  8. FEMS Immunol Med Microbiol. 2003 Mar 20;35(2):135-40 - PubMed
  9. J Clin Invest. 2010 Sep;120(9):3220-33 - PubMed
  10. J Bacteriol. 2006 Jul;188(13):4861-70 - PubMed
  11. Circulation. 1991 Dec;84(6):2539-46 - PubMed
  12. Microbiologyopen. 2019 Oct;8(10):e906 - PubMed
  13. Annu Rev Med. 2013;64:175-88 - PubMed
  14. PLoS Pathog. 2016 Nov 30;12(11):e1006024 - PubMed
  15. FEMS Microbiol Rev. 2015 Sep;39(5):649-69 - PubMed
  16. Cell Microbiol. 2009 Mar;11(3):421-32 - PubMed
  17. J Infect Dis. 1996 Oct;174(4):881-4 - PubMed
  18. J Bacteriol. 2005 Apr;187(7):2348-56 - PubMed
  19. Biomaterials. 2008 Nov;29(33):4374-82 - PubMed
  20. Nat Commun. 2016 Jul 29;7:12304 - PubMed
  21. Appl Environ Microbiol. 2008 Oct;74(19):6155-7 - PubMed
  22. J Wound Care. 2019 Feb 2;28(2):66-73 - PubMed
  23. Eur J Clin Microbiol Infect Dis. 2015 Apr;34(4):773-8 - PubMed
  24. Appl Microbiol Biotechnol. 2007 May;75(1):125-32 - PubMed
  25. Appl Microbiol. 1975 Sep;30(3):381-5 - PubMed
  26. J Clin Invest. 2011 Jan;121(1):238-48 - PubMed
  27. Front Microbiol. 2015 May 26;6:496 - PubMed
  28. Nucleic Acids Res. 2008 Mar;36(5):1567-77 - PubMed
  29. PLoS Pathog. 2012;8(4):e1002626 - PubMed
  30. Antimicrob Agents Chemother. 2019 Jan 29;63(2): - PubMed
  31. Appl Environ Microbiol. 2012 Aug;78(16):5890-6 - PubMed
  32. Antimicrob Agents Chemother. 2002 Mar;46(3):900-3 - PubMed
  33. Antimicrob Agents Chemother. 2013 Apr;57(4):1968-70 - PubMed
  34. Mol Microbiol. 2005 Mar;55(6):1883-95 - PubMed
  35. J Infect Dis. 1990 Aug;162(2):435-41 - PubMed
  36. Infect Immun. 2002 Aug;70(8):4433-40 - PubMed
  37. Clin Orthop Relat Res. 2006 Oct;451:21-4 - PubMed
  38. PLoS One. 2019 Jan 25;14(1):e0211132 - PubMed
  39. Mol Microbiol. 1996 Jun;20(5):1083-91 - PubMed
  40. Infect Immun. 2008 May;76(5):2044-50 - PubMed
  41. Biochemistry. 2013 Aug 13;52(32):5463-71 - PubMed
  42. Biomaterials. 2007 Mar;28(9):1711-20 - PubMed
  43. Antimicrob Agents Chemother. 1993 Dec;37(12):2522-6 - PubMed
  44. J Clin Microbiol. 2013 May;51(5):1541-7 - PubMed
  45. PLoS One. 2015 Apr 13;10(4):e0123206 - PubMed
  46. Chem Biol. 2012 Dec 21;19(12):1503-13 - PubMed
  47. Infect Immun. 2005 Oct;73(10):6868-76 - PubMed
  48. Antimicrob Agents Chemother. 2010 Sep;54(9):3746-55 - PubMed
  49. Infect Immun. 2001 Jun;69(6):4079-85 - PubMed
  50. J Med Microbiol. 2013 Jul;62(Pt 7):1051-1059 - PubMed
  51. PLoS One. 2016 Feb 12;11(2):e0149092 - PubMed
  52. J Med Microbiol. 2002 Apr;51(4):344-349 - PubMed
  53. Biofouling. 2009;25(4):367-75 - PubMed
  54. PLoS One. 2012;7(9):e43813 - PubMed
  55. J Infect Dis. 2005 Dec 1;192(11):2012-9 - PubMed
  56. J Antimicrob Chemother. 2009 Mar;63(3):485-8 - PubMed
  57. J Med Microbiol. 2013 Oct;62(Pt 10):1579-1587 - PubMed
  58. Infect Immun. 2005 Oct;73(10):6752-62 - PubMed
  59. Mol Microbiol. 2019 Jun;111(6):1571-1591 - PubMed
  60. Infect Immun. 2004 Jul;72(7):3838-48 - PubMed
  61. FEMS Microbiol Lett. 2006 Feb;255(1):11-6 - PubMed
  62. Infect Immun. 1999 May;67(5):2627-32 - PubMed
  63. Infect Immun. 2005 May;73(5):3188-91 - PubMed
  64. J Infect Dis. 2001 Apr 1;183(7):1038-42 - PubMed
  65. Appl Environ Microbiol. 2003 Sep;69(9):5648-55 - PubMed
  66. Pathog Dis. 2017 Jul 31;75(5): - PubMed
  67. Front Cell Infect Microbiol. 2012 Mar 26;2:38 - PubMed
  68. Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20700-20706 - PubMed
  69. Microb Pathog. 2007 Feb-Mar;42(2-3):94-7 - PubMed
  70. Sci Rep. 2018 Feb 2;8(1):2254 - PubMed
  71. J Clin Microbiol. 2001 Dec;39(12):4595-6 - PubMed
  72. Infect Immun. 1999 Oct;67(10):5427-33 - PubMed
  73. Infect Immun. 2007 Oct;75(10):4728-42 - PubMed
  74. J Bacteriol. 2005 Aug;187(15):5318-29 - PubMed
  75. Clin Infect Dis. 2012 Nov;55(9):1188-97 - PubMed
  76. Microb Pathog. 2014 Dec;77:89-99 - PubMed
  77. Infect Immun. 2004 Feb;72(2):1210-5 - PubMed
  78. J Infect Dis. 1994 Sep;170(3):720-3 - PubMed
  79. Appl Environ Microbiol. 2011 Dec;77(23):8303-9 - PubMed
  80. Eur Cell Mater. 2012 Nov 17;24:386-402 - PubMed
  81. Cell Microbiol. 2017 Dec;19(12): - PubMed
  82. Clin Microbiol Infect. 2004 Dec;10(12):1081-8 - PubMed
  83. Microbiol Spectr. 2015 Apr;3(2):MB-0001-2014 - PubMed
  84. Infect Immun. 1994 Aug;62(8):3244-53 - PubMed
  85. Infect Immun. 1996 Aug;64(8):3410-5 - PubMed
  86. Microb Pathog. 2007 Jul;43(1):1-9 - PubMed
  87. Nat Commun. 2018 Nov 28;9(1):5034 - PubMed
  88. Malawi Med J. 2018 Dec;30(4):243-249 - PubMed
  89. J Bacteriol. 1996 Jan;178(1):175-83 - PubMed
  90. J Clin Microbiol. 1985 Dec;22(6):1025-9 - PubMed
  91. Clin Microbiol Infect. 2011 Nov;17(11):1684-90 - PubMed
  92. Infect Immun. 2010 Jun;78(6):2877-89 - PubMed
  93. Antimicrob Agents Chemother. 2000 Dec;44(12):3357-63 - PubMed
  94. J Antimicrob Chemother. 2010 Sep;65(9):1955-8 - PubMed
  95. J Clin Microbiol. 2007 May;45(5):1379-88 - PubMed
  96. Infect Immun. 2011 Mar;79(3):1007-15 - PubMed
  97. PLoS Pathog. 2007 Apr;3(4):e57 - PubMed
  98. N Engl J Med. 1998 Aug 20;339(8):520-32 - PubMed
  99. Infect Immun. 1983 Apr;40(1):407-10 - PubMed
  100. J Infect Dis. 2003 Sep 1;188(5):706-18 - PubMed
  101. J Bacteriol. 2009 Oct;191(20):6363-73 - PubMed
  102. Microbiol Spectr. 2018 Aug;6(4): - PubMed
  103. J Bacteriol. 2019 Feb 25;201(6): - PubMed
  104. J Bacteriol. 2004 Dec;186(24):8213-20 - PubMed
  105. J Infect Dis. 2000 Jul;182(1):351-5 - PubMed
  106. J Hosp Infect. 2005 Dec;61(4):342-8 - PubMed
  107. Carbohydr Res. 2003 Apr 22;338(9):903-22 - PubMed
  108. Mol Microbiol. 2003 May;48(4):1075-87 - PubMed
  109. Front Cell Infect Microbiol. 2014 Nov 26;4:167 - PubMed
  110. PLoS One. 2018 Oct 10;13(10):e0205526 - PubMed
  111. BMC Res Notes. 2019 Oct 25;12(1):691 - PubMed
  112. J Biol Chem. 1998 Jul 17;273(29):18586-93 - PubMed
  113. Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1281-6 - PubMed
  114. Front Microbiol. 2015 Oct 27;6:1174 - PubMed
  115. Future Microbiol. 2012 Sep;7(9):1061-72 - PubMed
  116. J Bacteriol. 2003 May;185(9):2879-86 - PubMed
  117. Int J Med Microbiol. 2015 Dec;305(8):948-56 - PubMed
  118. PLoS Pathog. 2019 Mar 14;15(3):e1007618 - PubMed
  119. Infect Immun. 2011 Jun;79(6):2267-76 - PubMed
  120. Science. 1999 May 28;284(5419):1523-7 - PubMed
  121. J Bacteriol. 2002 Aug;184(16):4400-8 - PubMed
  122. J Med Microbiol. 2007 Jan;56(Pt 1):83-93 - PubMed
  123. J Infect Dis. 2008 Apr 1;197(7):1028-35 - PubMed
  124. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):E2209-18 - PubMed
  125. J Bacteriol. 2004 May;186(9):2724-34 - PubMed
  126. Mol Microbiol. 2003 May;48(4):889-99 - PubMed
  127. FEMS Microbiol Rev. 2017 May 1;41(3):276-301 - PubMed
  128. Int J Biochem Cell Biol. 2008;40(3):355-61 - PubMed
  129. Infection. 2005 Feb;33(1):3-8 - PubMed
  130. Infect Immun. 2017 Jul 19;85(8): - PubMed
  131. Mol Cell. 2008 Oct 10;32(1):150-8 - PubMed
  132. J Bacteriol. 2005 Jan;187(1):382-7 - PubMed
  133. Infect Immun. 2007 Jul;75(7):3406-13 - PubMed
  134. Folia Microbiol (Praha). 2015 Jan;60(1):1-5 - PubMed
  135. J Bacteriol. 2008 Aug;190(15):5178-89 - PubMed
  136. Front Biosci. 2004 Jan 01;9:841-63 - PubMed
  137. BMC Microbiol. 2012 May 17;12:76 - PubMed
  138. PLoS One. 2011;6(11):e26714 - PubMed
  139. Infect Immun. 2005 May;73(5):3007-17 - PubMed
  140. Vaccine. 2009 Apr 14;27(17):2379-86 - PubMed
  141. J Biomed Mater Res. 2002 Mar 5;59(3):557-62 - PubMed
  142. J Clin Microbiol. 2004 Dec;42(12):5614-9 - PubMed
  143. FEBS Lett. 2014 May 21;588(10):1869-72 - PubMed
  144. J Bacteriol. 2007 Apr;189(7):2886-96 - PubMed
  145. J Biol Chem. 2015 Jul 31;290(31):19261-72 - PubMed
  146. Infect Immun. 1997 Mar;65(3):890-6 - PubMed
  147. Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):E3106-E3115 - PubMed
  148. J Clin Microbiol. 1999 Oct;37(10):3235-8 - PubMed
  149. J Biol Chem. 2004 Dec 24;279(52):54881-6 - PubMed
  150. Can J Microbiol. 2007 Jan;53(1):82-91 - PubMed
  151. PLoS One. 2016 Mar 15;11(3):e0151240 - PubMed
  152. Infect Immun. 2005 Mar;73(3):1856-60 - PubMed
  153. Arch Biochem Biophys. 1994 Feb 1;308(2):432-8 - PubMed
  154. J Bacteriol. 1996 Jan;178(2):418-23 - PubMed
  155. Mol Microbiol. 1999 Apr;32(2):345-56 - PubMed
  156. Infect Immun. 2010 Feb;78(2):764-72 - PubMed
  157. J Infect Dis. 1988 Apr;157(4):713-22 - PubMed
  158. J Bacteriol. 2008 Oct;190(19):6530-3 - PubMed
  159. PLoS Genet. 2013;9(12):e1004001 - PubMed
  160. Infect Immun. 1999 May;67(5):2656-9 - PubMed
  161. J Biomed Mater Res A. 2007 Mar 1;80(3):742-51 - PubMed
  162. Environ Microbiol. 2008 Jun;10(6):1419-32 - PubMed
  163. FEMS Immunol Med Microbiol. 2011 Nov;63(2):269-80 - PubMed
  164. Front Microbiol. 2019 Sep 18;10:2162 - PubMed
  165. J Bacteriol. 2007 Feb;189(3):750-60 - PubMed
  166. J Microbiol Immunol Infect. 2015 Aug;48(4):397-405 - PubMed
  167. Infect Immun. 2008 Nov;76(11):5127-32 - PubMed
  168. Nat Rev Microbiol. 2011 Apr;9(4):244-53 - PubMed
  169. Nat Rev Microbiol. 2008 Apr;6(4):276-87 - PubMed
  170. Antonie Van Leeuwenhoek. 2017 Nov;110(11):1467-1474 - PubMed
  171. Mol Microbiol. 2007 Sep;65(5):1276-87 - PubMed
  172. Arch Biochem Biophys. 1997 Jun 15;342(2):389-95 - PubMed
  173. J Clin Microbiol. 2000 Feb;38(2):877-80 - PubMed
  174. Appl Environ Microbiol. 2008 Jan;74(2):470-6 - PubMed
  175. J Bacteriol. 2009 Oct;191(19):5953-63 - PubMed
  176. mSphere. 2016 Oct 5;1(5): - PubMed
  177. J Clin Microbiol. 2005 Apr;43(4):1973-6 - PubMed
  178. Infect Immun. 2005 Aug;73(8):4596-606 - PubMed
  179. J Med Microbiol. 2014 Jun;63(Pt 6):884-891 - PubMed
  180. Curr Opin Microbiol. 2007 Dec;10(6):644-8 - PubMed
  181. J Infect Dis. 2008 May 1;197(9):1254-62 - PubMed
  182. Int J Med Microbiol. 2007 Apr;297(2):117-22 - PubMed
  183. BMC Biol. 2014 May 29;12:41 - PubMed
  184. Curr Eye Res. 2006 Feb;31(2):137-46 - PubMed
  185. Clin Microbiol Infect. 2008 Dec;14(12):1135-45 - PubMed
  186. J Bacteriol. 2003 Aug;185(16):4693-8 - PubMed
  187. Infect Immun. 1986 Jan;51(1):294-301 - PubMed
  188. Adv Colloid Interface Sci. 2018 Nov;261:1-14 - PubMed
  189. Infect Immun. 1992 Apr;60(4):1363-7 - PubMed
  190. J Mol Biol. 2019 Jul 26;431(16):3015-3027 - PubMed
  191. J Bacteriol. 2019 May 8;201(11): - PubMed
  192. Expert Rev Vaccines. 2016 Aug;15(8):1041-53 - PubMed
  193. Infect Immun. 2006 Jan;74(1):488-96 - PubMed
  194. Curr Top Microbiol Immunol. 2017;404:1-44 - PubMed
  195. Carbohydr Res. 2003 Nov 14;338(23):2539-47 - PubMed
  196. Cell Microbiol. 2014 Jul;16(7):1105-18 - PubMed
  197. PLoS Pathog. 2018 Jul 19;14(7):e1007160 - PubMed
  198. J Med Microbiol. 2019 May;68(5):791-802 - PubMed
  199. Infect Immun. 2013 Sep;81(9):3227-38 - PubMed
  200. PLoS Pathog. 2014 Jul 31;10(7):e1004292 - PubMed
  201. J Bacteriol. 2004 Apr;186(8):2449-56 - PubMed
  202. Trends Microbiol. 2019 Nov;27(11):927-941 - PubMed
  203. ACS Nano. 2016 Mar 22;10(3):3443-52 - PubMed
  204. Transfusion. 2014 Feb;54(2):461-70 - PubMed
  205. J Bacteriol. 2004 Sep;186(18):6208-19 - PubMed
  206. Curr Microbiol. 2015 Jun;70(6):829-34 - PubMed
  207. J Hosp Infect. 2005 Nov;61(3):225-30 - PubMed
  208. Invest Ophthalmol Vis Sci. 2018 May 1;59(6):2512-2519 - PubMed
  209. Front Microbiol. 2019 Aug 27;10:1971 - PubMed

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