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Ferreira MS, Jones MR, Callahan CM, et al. The Legacy of Recurrent Introgression during the Radiation of Hares. Syst Biol. 2021;70(3):593-607doi: 10.1093/sysbio/syaa088.
Ferreira, M. S., Jones, M. R., Callahan, C. M., Farelo, L., Tolesa, Z., Suchentrunk, F., Boursot, P., Mills, L. S., Alves, P. C., Good, J. M., & Melo-Ferreira, J. (2021). The Legacy of Recurrent Introgression during the Radiation of Hares. Systematic biology, 70(3), 593-607. https://doi.org/10.1093/sysbio/syaa088
Ferreira, Mafalda S, et al. "The Legacy of Recurrent Introgression during the Radiation of Hares." Systematic biology vol. 70,3 (2021): 593-607. doi: https://doi.org/10.1093/sysbio/syaa088
Ferreira MS, Jones MR, Callahan CM, Farelo L, Tolesa Z, Suchentrunk F, Boursot P, Mills LS, Alves PC, Good JM, Melo-Ferreira J. The Legacy of Recurrent Introgression during the Radiation of Hares. Syst Biol. 2021 Apr 15;70(3):593-607. doi: 10.1093/sysbio/syaa088. PMID: 33263746; PMCID: PMC8048390.
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Syst Biol. 2021 Apr 15;70(3):593-607. doi: 10.1093/sysbio/syaa088.

The Legacy of Recurrent Introgression during the Radiation of Hares.

Systematic biology

Mafalda S Ferreira, Matthew R Jones, Colin M Callahan, Liliana Farelo, Zelalem Tolesa, Franz Suchentrunk, Pierre Boursot, L Scott Mills, Paulo C Alves, Jeffrey M Good, José Melo-Ferreira

Affiliations

  1. CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, InBIO Laboratório Associado, Universidade do Porto, Vairão, Portugal.
  2. Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, Porto, Portugal.
  3. Division of Biological Sciences, University of Montana, Missoula, Montana, United States of America.
  4. Department of Biology, Hawassa University, Hawassa, Ethiopia.
  5. Department for Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology, University of Veterinary Medicine Vienna, Vienna, Austria.
  6. Institut des Sciences de l'Évolution Montpellier (ISEM), Université de Montpellier, CNRS, IRD, EPHE, France.
  7. Wildlife Biology Program, College of Forestry and Conservation, University of Montana, Missoula, Montana, United States of America.
  8. Office of Research and Creative Scholarship, University of Montana, Missoula, Montana, United States of America; Jeffrey M. Good and José Melo-Ferreira shared the senior authorship.

PMID: 33263746 PMCID: PMC8048390 DOI: 10.1093/sysbio/syaa088

Abstract

Hybridization may often be an important source of adaptive variation, but the extent and long-term impacts of introgression have seldom been evaluated in the phylogenetic context of a radiation. Hares (Lepus) represent a widespread mammalian radiation of 32 extant species characterized by striking ecological adaptations and recurrent admixture. To understand the relevance of introgressive hybridization during the diversification of Lepus, we analyzed whole exome sequences (61.7 Mb) from 15 species of hares (1-4 individuals per species), spanning the global distribution of the genus, and two outgroups. We used a coalescent framework to infer species relationships and divergence times, despite extensive genealogical discordance. We found high levels of allele sharing among species and show that this reflects extensive incomplete lineage sorting and temporally layered hybridization. Our results revealed recurrent introgression at all stages along the Lepus radiation, including recent gene flow between extant species since the last glacial maximum but also pervasive ancient introgression occurring since near the origin of the hare lineages. We show that ancient hybridization between northern hemisphere species has resulted in shared variation of potential adaptive relevance to highly seasonal environments, including genes involved in circadian rhythm regulation, pigmentation, and thermoregulation. Our results illustrate how the genetic legacy of ancestral hybridization may persist across a radiation, leaving a long-lasting signature of shared genetic variation that may contribute to adaptation. [Adaptation; ancient introgression; hybridization; Lepus; phylogenomics.].

© The Author(s) 2020. Published by Oxford University Press, on behalf of the Society of Systematic Biologists.

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