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Wu Q, Chen X, Li J, et al. Serine and Metabolism Regulation: A Novel Mechanism in Antitumor Immunity and Senescence. Aging Dis. 2020;11(6):1640-1653doi: 10.14336/AD.2020.0314.
Wu, Q., Chen, X., Li, J., & Sun, S. (2020). Serine and Metabolism Regulation: A Novel Mechanism in Antitumor Immunity and Senescence. Aging and disease, 11(6), 1640-1653. https://doi.org/10.14336/AD.2020.0314
Wu, Qi, et al. "Serine and Metabolism Regulation: A Novel Mechanism in Antitumor Immunity and Senescence." Aging and disease vol. 11,6 (2020): 1640-1653. doi: https://doi.org/10.14336/AD.2020.0314
Wu Q, Chen X, Li J, Sun S. Serine and Metabolism Regulation: A Novel Mechanism in Antitumor Immunity and Senescence. Aging Dis. 2020 Dec 01;11(6):1640-1653. doi: 10.14336/AD.2020.0314. eCollection 2020 Dec. PMID: 33269112; PMCID: PMC7673844.
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Aging Dis. 2020 Dec 01;11(6):1640-1653. doi: 10.14336/AD.2020.0314. eCollection 2020 Dec.

Serine and Metabolism Regulation: A Novel Mechanism in Antitumor Immunity and Senescence.

Aging and disease

Qi Wu, Xinyue Chen, Juanjuan Li, Shengrong Sun

Affiliations

  1. 1Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.

PMID: 33269112 PMCID: PMC7673844 DOI: 10.14336/AD.2020.0314

Abstract

As one of the nonessential amino acids (NEAAs), serine is involved in the anabolism of multiple macromolecular substances by participating in one-carbon unit metabolism. Thus, rapidly proliferating cells such as tumor cells and activated immune cells are highly dependent on serine. Serine supports the proliferation of various immune cells through multiple pathways to enhance the antitumor immune response. Moreover, serine influences aging specificity in an epigenetic and metabolic manner. In this review, we focus on recent advances in the relationship between serine metabolism, antitumor immunity, and senescence. The metabolic regulation of serine seems to be a key point of intervention in antitumor immunity and aging-related disease, providing an opportunity for several novel therapeutics.

copyright: © 2020 Wu et al.

Keywords: Serine; antitumor immunity and senescence; metabolism

Conflict of interest statement

Conflicts of Interest No potential conflicts of interest were disclosed.

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