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Hang J, Lau SY, Yin R, et al. The role of phosphoprotein phosphatases catalytic subunit genes in pancreatic cancer. Biosci Rep. 2021;41(1)doi: 10.1042/BSR20203282.
Hang, J., Lau, S. Y., Yin, R., Zhu, L., Zhou, S., Yuan, X., & Wu, L. (2021). The role of phosphoprotein phosphatases catalytic subunit genes in pancreatic cancer. Bioscience reports, 41(1), . https://doi.org/10.1042/BSR20203282
Hang, Junjie, et al. "The role of phosphoprotein phosphatases catalytic subunit genes in pancreatic cancer." Bioscience reports vol. 41,1 (2021). doi: https://doi.org/10.1042/BSR20203282
Hang J, Lau SY, Yin R, Zhu L, Zhou S, Yuan X, Wu L. The role of phosphoprotein phosphatases catalytic subunit genes in pancreatic cancer. Biosci Rep. 2021 Jan 29;41(1). doi: 10.1042/BSR20203282. PMID: 33270085; PMCID: PMC7785039.
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Biosci Rep. 2021 Jan 29;41(1). doi: 10.1042/BSR20203282.

The role of phosphoprotein phosphatases catalytic subunit genes in pancreatic cancer.

Bioscience reports

Junjie Hang, Steven Yuk-Fai Lau, Ruohan Yin, Lina Zhu, Siyuan Zhou, Xin Yuan, Lixia Wu

Affiliations

  1. Changzhou No. 2 People's Hospital, Nanjing Medical University, Xinglong Road 19, Changzhou 213000, China.
  2. Division of Biostatistics, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China.
  3. Department of Oncology, Shanghai JingAn District ZhaBei Central Hospital, Zhonghuaxin Road 619, Shanghai 200040, China.

PMID: 33270085 PMCID: PMC7785039 DOI: 10.1042/BSR20203282

Abstract

Compelling evidence suggests that phosphoprotein phosphatases (PPPs) are involved in a large spectrum of physiological and pathological processes, but little is known about their roles in pancreatic cancer. We investigated the expression level, prognostic value, and potential function of PPPs with data from Oncomine, GEPIA, THPA, and TCGA databases and an independent cohort of patients with pancreatic cancer. Among all the PPP catalytic subunits (PPPcs), the transcription levels of PPP1CA, PPP1CB, PPP3CA, PPP3CB, and PPP4C were higher in pancreatic cancer than in normal pancreas (P<0.01, fold change > 2). Kaplan-Meier analysis showed that high transcription levels of PPP1CA, PPP1CB, PPP2CA, PPP2CB, PPP3CA, and PPP4C correlated with poorer survival. In contrast, patients with high levels of PPP3CB, PPP3CC, PPP5C, PPP6C, and PPEF2 had much better prognoses. Data from THPA and patients with pancreatic cancer enrolled in our hospital also confirmed the prognostic value of PPP1CA, PPP1CB, PPP2CA, PPP2CB, PPP3CA, PPP3CB, and PPP6C at the protein level. In addition, the Pearson Chi-square test showed that PPP3CB level was significantly correlated with T and N stages. GO and KEGG analyses showed that the genes and pathways related to the pathogenesis and progression of pancreatic cancer were greatly affected by alterations in PPPcs. Results of the present study suggest that PPP1CA, PPP1CB, PPP2CA, PPP2CB, and PPP3CA have deleterious effects but PPP3CB, PPP5C, and PPP6C have beneficial effects on pancreatic cancer.

© 2021 The Author(s).

Keywords: biological function; pancreatic cancer; phosphoprotein phosphatases catalytic subunit; prognostic value

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