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Front Neurosci. 2020 Oct 19;14:567129. doi: 10.3389/fnins.2020.567129. eCollection 2020.

Dopamine, Alpha-Synuclein, and Mitochondrial Dysfunctions in Parkinsonian Eyes.

Frontiers in neuroscience

Alessia Indrieri, Rocco Pizzarelli, Brunella Franco, Elvira De Leonibus

Affiliations

  1. Telethon Institute of Genetics and Medicine, Pozzuoli, Italy.
  2. Institute for Genetic and Biomedical Research, National Research Council, Milan, Italy.
  3. Center for Life Nanoscience, Istituto Italiano di Tecnologia, Rome, Italy.
  4. Medical Genetics, Department of Translational Medical Science, University of Naples "Federico II", Naples, Italy.
  5. Institute of Biochemistry and Cellular Biology, National Research Council, Rome, Italy.

PMID: 33192254 PMCID: PMC7604532 DOI: 10.3389/fnins.2020.567129

Abstract

Parkinson's disease (PD) is characterized by motor dysfunctions including bradykinesia, tremor at rest and motor instability. These symptoms are associated with the progressive degeneration of dopaminergic neurons originating in the

Copyright © 2020 Indrieri, Pizzarelli, Franco and De Leonibus.

Keywords: Parkinson’ disease; alpha-synuclein; dopamine; mitochondria; optic neuropathies; parkinsonism; retina; visual dysfunctions

References

  1. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):E4016-25 - PubMed
  2. Mov Disord. 2014 Jan;29(1):61-7 - PubMed
  3. EMBO Mol Med. 2019 May;11(5): - PubMed
  4. Parkinsonism Relat Disord. 2018 Nov;56:41-46 - PubMed
  5. Mov Disord. 2014 Jan;29(1):15-22 - PubMed
  6. Neuron. 2013 Sep 18;79(6):1044-66 - PubMed
  7. Lancet Neurol. 2006 Jun;5(6):525-35 - PubMed
  8. J Neuroophthalmol. 2013 Mar;33(1):62-5 - PubMed
  9. Vision Res. 1995 Sep;35(18):2659-64 - PubMed
  10. J Clin Neurophysiol. 2006 Oct;23(5):431-5 - PubMed
  11. J Biol Chem. 1986 Jun 15;261(17):7585-7 - PubMed
  12. Brain. 2018 Feb 1;141(2):505-520 - PubMed
  13. J Neurosci. 2006 Jan 4;26(1):41-50 - PubMed
  14. Neurol Sci. 2015 Feb;36(2):257-62 - PubMed
  15. Neuron. 1997 May;18(5):723-36 - PubMed
  16. Neurology. 1988 Feb;38(2):336-7 - PubMed
  17. Mol Cell Neurosci. 2013 Jul;55:62-76 - PubMed
  18. J Neurol Neurosurg Psychiatry. 1987 Sep;50(9):1243-4 - PubMed
  19. Mol Vis. 2007 Jun 18;13:949-61 - PubMed
  20. Sci Rep. 2017 Mar 10;7:44373 - PubMed
  21. Parkinsonism Relat Disord. 2013 Jan;19(1):1-14 - PubMed
  22. Neurology. 2005 Dec 27;65(12):1907-13 - PubMed
  23. Arch Neurol. 1982 May;39(5):284-6 - PubMed
  24. J Neurosci. 2012 Jul 4;32(27):9359-68 - PubMed
  25. Brain. 1995 Jun;118 ( Pt 3):771-8 - PubMed
  26. Cell Tissue Res. 2004 Oct;318(1):121-34 - PubMed
  27. J Geriatr Psychiatry Neurol. 2006 Mar;19(1):36-40 - PubMed
  28. Mov Disord. 2017 Mar;32(3):346-363 - PubMed
  29. J Neurol. 2001 Nov;248(11):975-8 - PubMed
  30. Eur J Neurol. 2013 Jan;20(1):198-201 - PubMed
  31. Ann Neurol. 2020 Nov;88(5):893-906 - PubMed
  32. Acta Neuropathol Commun. 2016 Jun 23;4(1):62 - PubMed
  33. J Parkinsons Dis. 2014;4(3):317-9 - PubMed
  34. Eur J Ophthalmol. 2011 Jan-Feb;21(1):24-9 - PubMed
  35. Mov Disord. 1992;7(3):232-8 - PubMed
  36. Neurology. 2006 Mar 28;66(6):845-51 - PubMed
  37. Sci Transl Med. 2010 Oct 6;2(52):52ra73 - PubMed
  38. J Neurol Sci. 2000 Jan 1;172(1):7-11 - PubMed
  39. Life Sci. 1988;43(3):255-62 - PubMed
  40. EMBO J. 2012 Jun 26;31(14):3038-62 - PubMed
  41. Trends Pharmacol Sci. 1994 Jul;15(7):264-70 - PubMed
  42. J Parkinsons Dis. 2016;6(1):39-51 - PubMed
  43. Lancet Neurol. 2008 Jan;7(1):97-109 - PubMed
  44. Mov Disord. 2012 Dec;27(14):1781-8 - PubMed
  45. J Parkinsons Dis. 2015;5(4):681-97 - PubMed
  46. Clin Neuropsychol. 2013;27(7):1167-78 - PubMed
  47. Neurosci Biobehav Rev. 2008;32(4):611-56 - PubMed
  48. Clin Exp Optom. 2011 Mar;94(2):150-60 - PubMed
  49. Prog Retin Eye Res. 2014 Mar;39:58-76 - PubMed
  50. Neuropsychologia. 2009 Jan;47(2):314-20 - PubMed
  51. Parkinsons Dis. 2018 Jul 11;2018:3201308 - PubMed
  52. Nippon Ganka Gakkai Zasshi. 1992 Jun;96(6):767-75 - PubMed
  53. Neurocase. 2014 Apr;20(2):121-32 - PubMed
  54. J Ophthalmol. 2016;2016:8503859 - PubMed
  55. Mov Disord. 2014 Oct;29(12):1547-51 - PubMed
  56. Mov Disord. 2005 Feb;20(2):130-40 - PubMed
  57. Neuron. 2001 Apr;30(1):211-25 - PubMed
  58. Science. 1975 Apr 18;188(4185):270-3 - PubMed
  59. Neurobiol Dis. 2019 Jan;121:1-16 - PubMed
  60. Lancet Neurol. 2013 May;12(5):443-53 - PubMed
  61. J Ophthalmol. 2012;2012:728457 - PubMed
  62. Acta Neuropathol. 2016 Dec;132(6):789-806 - PubMed
  63. Nature. 1997 Aug 28;388(6645):839-40 - PubMed
  64. J Neural Transm Park Dis Dement Sect. 1994;7(1):13-9 - PubMed
  65. Mov Disord. 2011 Nov;26(13):2387-95 - PubMed
  66. Proc Natl Acad Sci U S A. 1985 Apr;82(7):2173-7 - PubMed
  67. Neurology. 1995 Feb;45(2):386-7 - PubMed
  68. Curr Neurol Neurosci Rep. 2017 Sep;17(9):66 - PubMed
  69. J Clin Exp Neuropsychol. 2001 Oct;23(5):592-8 - PubMed
  70. Neurobiol Aging. 2003 Mar-Apr;24(2):197-211 - PubMed
  71. Vision Res. 2004 Nov;44(24):2793-7 - PubMed
  72. Ann Neurol. 2014 Jun;75(6):964-6 - PubMed
  73. Neuron. 1995 Feb;14(2):467-75 - PubMed
  74. Science. 2000 Feb 18;287(5456):1265-9 - PubMed
  75. J Biol Chem. 2011 Jun 10;286(23):20710-26 - PubMed
  76. Prog Retin Eye Res. 2011 Mar;30(2):81-114 - PubMed
  77. Int J Mol Sci. 2020 Mar 18;21(6): - PubMed
  78. Acta Neuropathol. 2019 Mar;137(3):379-395 - PubMed
  79. Vision Res. 1998 May;38(10):1479-87 - PubMed
  80. Ann Neurol. 2015 Jan;77(1):15-32 - PubMed
  81. J Neuropathol Exp Neurol. 2011 Jan;70(1):63-8 - PubMed
  82. J Comp Neurol. 2005 Dec 12;493(2):261-73 - PubMed
  83. Neurology. 2011 Jul 26;77(4):325-33 - PubMed
  84. Hum Mol Genet. 2013 Jun 1;22(11):2129-40 - PubMed
  85. Surg Radiol Anat. 1988;10(2):137-44 - PubMed
  86. Invest Ophthalmol Vis Sci. 1990 Nov;31(11):2473-5 - PubMed
  87. Arch Neurobiol (Madr). 1990 Jan-Feb;53(1):1-7 - PubMed
  88. Sci Rep. 2020 Jun 15;10(1):9619 - PubMed
  89. J Parkinsons Dis. 2014;4(2):197-204 - PubMed
  90. J Neurosci. 2000 Sep 1;20(17):6365-73 - PubMed
  91. Graefes Arch Clin Exp Ophthalmol. 2018 Feb;256(2):237-245 - PubMed
  92. Acta Neurol Scand. 2002 Apr;105(4):256-60 - PubMed
  93. J Mov Disord. 2019 Sep;12(3):139-151 - PubMed
  94. Brain Res. 1990 Sep 10;527(1):21-31 - PubMed
  95. Lancet. 2015 Aug 29;386(9996):896-912 - PubMed
  96. Ann Neurol. 1987 Sep;22(3):365-9 - PubMed
  97. Mov Disord. 2015 Oct;30(12):1591-601 - PubMed
  98. Lancet Neurol. 2020 Feb;19(2):170-178 - PubMed
  99. Br J Ophthalmol. 1984 Dec;68(12):885-9 - PubMed
  100. Parkinsonism Relat Disord. 2017 Jan;34:15-19 - PubMed
  101. Neuron. 2010 Jan 14;65(1):66-79 - PubMed
  102. Nat Med. 2017 Feb 7;23(2):1-13 - PubMed
  103. Brain Behav. 2017 Apr 07;7(5):e00703 - PubMed
  104. J Parkinsons Dis. 2015;5(4):715-26 - PubMed
  105. J Neurosci. 1998 Sep 1;18(17):6776-89 - PubMed
  106. J Neurosci. 1999 Sep 15;19(18):7812-22 - PubMed
  107. J Neurol Neurosurg Psychiatry. 2001 Jun;70(6):734-8 - PubMed
  108. Neuron. 2018 Jan 3;97(1):108-124.e6 - PubMed
  109. J Neuroophthalmol. 2013 Jun;33(2):137-42 - PubMed
  110. Doc Ophthalmol. 2015 Oct;131(2):95-104 - PubMed
  111. EMBO J. 2010 Oct 20;29(20):3571-89 - PubMed
  112. J Neural Transm (Vienna). 2013 May;120(5):745-53 - PubMed
  113. Brain Res. 2006 Aug 23;1106(1):134-141 - PubMed
  114. Expert Rev Pharmacoecon Outcomes Res. 2015;15(6):889-911 - PubMed
  115. Eur J Ophthalmol. 2007 Sep-Oct;17(5):812-6 - PubMed
  116. Mov Disord. 2012 Apr 15;27(5):617-26 - PubMed
  117. Ann Neurol. 2011 May;69(5):811-8 - PubMed
  118. Parkinsonism Relat Disord. 2011 Jul;17(6):431-6 - PubMed
  119. Neurochem Res. 2012 May;37(5):1050-6 - PubMed
  120. Ageing Res Rev. 2018 Mar;42:72-85 - PubMed
  121. J Biol Chem. 2011 Mar 25;286(12):10814-24 - PubMed
  122. Eur J Neurosci. 1996 Nov;8(11):2286-97 - PubMed
  123. Neurobiol Dis. 2011 Oct;44(1):102-15 - PubMed
  124. Biochim Biophys Acta. 2009 May;1787(5):518-28 - PubMed
  125. Parkinsonism Relat Disord. 2017 Jul;40:1-10 - PubMed
  126. Mov Disord. 2010 May 15;25(7):882-7 - PubMed
  127. J Neurosci. 2015 Jan 21;35(3):890-905 - PubMed
  128. Ann Neurol. 1989 Apr;25(4):357-64 - PubMed
  129. J Parkinsons Dis. 2015;5(1):125-30 - PubMed
  130. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4087-92 - PubMed
  131. Mov Disord. 2012 Apr 15;27(5):608-16 - PubMed
  132. J Pharmacol Sci. 2019 May;140(1):86-93 - PubMed
  133. Prog Neurobiol. 2020 Feb;185:101729 - PubMed
  134. Brain Pathol. 2014 Jan;24(1):25-32 - PubMed
  135. Mov Disord. 2018 Sep;33(9):1390-1406 - PubMed
  136. Brain. 2000 Apr;123 ( Pt 4):733-45 - PubMed
  137. Trends Neurosci. 2001 May;24(5):245-7 - PubMed
  138. Annu Rev Vis Sci. 2015 Nov 24;1:263-289 - PubMed
  139. Vision Res. 1994 Aug;34(16):2051-7 - PubMed
  140. Acta Ophthalmol. 2008 Jun;86(4):395-400 - PubMed
  141. Doc Ophthalmol. 2004 Jan;108(1):17-40 - PubMed
  142. Electroencephalogr Clin Neurophysiol. 1987 Apr;66(4):349-57 - PubMed
  143. Invest Ophthalmol Vis Sci. 2009 Jun;50(6):2567-71 - PubMed
  144. Science. 1983 Feb 25;219(4587):979-80 - PubMed
  145. J Neurol. 2017 Sep;264(9):2027-2030 - PubMed
  146. Kaohsiung J Med Sci. 2018 Mar;34(3):166-171 - PubMed
  147. BMJ Open. 2016 May 06;6(5):e009658 - PubMed
  148. Psychiatry Res. 1979 Dec;1(3):249-54 - PubMed
  149. J Bioenerg Biomembr. 2009 Dec;41(6):499-503 - PubMed
  150. Mov Disord. 2018 Aug;33(8):1315-1324 - PubMed
  151. J Neurochem. 2016 Oct;139 Suppl 1:216-231 - PubMed
  152. J Neurol. 2019 Sep;266(9):2103-2111 - PubMed
  153. Mov Disord. 1994 Sep;9(5):563-70 - PubMed
  154. Vision Res. 1994 Oct;34(19):2629-38 - PubMed
  155. Brain. 1987 Dec;110 ( Pt 6):1675-98 - PubMed
  156. Mov Disord. 2010 Aug 15;25(11):1590-6 - PubMed
  157. Arch Neurol. 1993 Jul;50(7):721-4 - PubMed
  158. Neurocase. 2010 Dec;16(6):466-87 - PubMed
  159. Brain. 2005 Oct;128(Pt 10):2260-71 - PubMed
  160. Neurochem Int. 2007 Jan;50(1):189-95 - PubMed
  161. Arch Neurol. 2002 Aug;59(8):1249-52 - PubMed
  162. Radiology. 2017 Dec;285(3):885-895 - PubMed
  163. Nat Neurosci. 2020 Mar;23(3):327-336 - PubMed
  164. Brain. 2016 Nov 1;139(11):2827-2843 - PubMed
  165. J Comp Neurol. 1995 May 8;355(3):392-404 - PubMed
  166. Parkinsonism Relat Disord. 2016 Jan;22 Suppl 1:S134-7 - PubMed
  167. J Neurophysiol. 2018 Mar 1;119(3):957-970 - PubMed
  168. Neurosci Lett. 2014 Jun 13;571:34-8 - PubMed
  169. Mov Disord. 2010 Oct 30;25(14):2461-2 - PubMed
  170. EMBO J. 2014 Nov 3;33(21):2442-3 - PubMed
  171. Clin Ophthalmol. 2010 Dec 06;4:1427-32 - PubMed
  172. J Biomed Biotechnol. 2012;2012:845618 - PubMed
  173. Acta Neuropathol Commun. 2016 Aug 18;4(1):86 - PubMed
  174. Free Radic Biol Med. 2013 Oct;63:1-29 - PubMed
  175. Neurology. 1992 Apr;42(4):887-90 - PubMed
  176. J Alzheimers Dis. 2013;34(3):659-64 - PubMed
  177. BMC Ophthalmol. 2012 Oct 02;12:54 - PubMed
  178. Sci Transl Med. 2016 Jun 8;8(342):342ra78 - PubMed
  179. Nat Neurosci. 2000 Dec;3(12):1301-6 - PubMed
  180. PLoS One. 2012;7(4):e34891 - PubMed
  181. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3213-9 - PubMed

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