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Chen S, Takahashi N, Chen C, et al. Transient Receptor Potential Ankyrin 1 Mediates Hypoxic Responses in Mice. Front Physiol. 2020;11:576209doi: 10.3389/fphys.2020.576209.
Chen, S., Takahashi, N., Chen, C., Pauli, J. L., Kuroki, C., Kaminosono, J., Kashiwadani, H., Kanmura, Y., Mori, Y., Ou, S., Hao, L., & Kuwaki, T. (2020). Transient Receptor Potential Ankyrin 1 Mediates Hypoxic Responses in Mice. Frontiers in physiology, 11576209. https://doi.org/10.3389/fphys.2020.576209
Chen, Sichong, et al. "Transient Receptor Potential Ankyrin 1 Mediates Hypoxic Responses in Mice." Frontiers in physiology vol. 11 (2020): 576209. doi: https://doi.org/10.3389/fphys.2020.576209
Chen S, Takahashi N, Chen C, Pauli JL, Kuroki C, Kaminosono J, Kashiwadani H, Kanmura Y, Mori Y, Ou S, Hao L, Kuwaki T. Transient Receptor Potential Ankyrin 1 Mediates Hypoxic Responses in Mice. Front Physiol. 2020 Oct 22;11:576209. doi: 10.3389/fphys.2020.576209. eCollection 2020. PMID: 33192579; PMCID: PMC7642990.
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Front Physiol. 2020 Oct 22;11:576209. doi: 10.3389/fphys.2020.576209. eCollection 2020.

Transient Receptor Potential Ankyrin 1 Mediates Hypoxic Responses in Mice.

Frontiers in physiology

Sichong Chen, Nobuaki Takahashi, Changping Chen, Jordan L Pauli, Chiharu Kuroki, Jun Kaminosono, Hideki Kashiwadani, Yuichi Kanmura, Yasuo Mori, Shaowu Ou, Liying Hao, Tomoyuki Kuwaki

Affiliations

  1. Department of Physiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
  2. Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang, China.
  3. Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
  4. The Hakubi Center for Advanced Research, Kyoto University, Kyoto, Japan.
  5. Department of Neurosurgery, First Affiliated Hospital of China Medical University, Shenyang, China.
  6. Department of Anesthesiology and Critical Care Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.

PMID: 33192579 PMCID: PMC7642990 DOI: 10.3389/fphys.2020.576209

Abstract

Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel that is broadly expressed in sensory pathways, such as the trigeminal and vagus nerves. It is capable of detecting various irritants in inspired gasses and is activated during hypoxia. In this study, the role of TRPA1 in hypoxia-induced behavioral, respiratory, and cardiovascular responses was examined through four lines of experiments using TRPA1 knockout (KO) mice and wild type (WT) littermates. First, KO mice showed significantly attenuated avoidance behavior in response to a low (15%) oxygen environment. Second, the wake-up response to a hypoxic ramp (from 21 to 10% O

Copyright © 2020 Chen, Takahashi, Chen, Pauli, Kuroki, Kaminosono, Kashiwadani, Kanmura, Mori, Ou, Hao and Kuwaki.

Keywords: avoidance behavior; hypoxic arousal; respiratory chemoreflex; transient receptor potential ankyrin-1; trigeminal afferent nerve

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