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Odle RI, Florey O, Ktistakis NT, et al. CDK1, the Other 'Master Regulator' of Autophagy. Trends Cell Biol. 2020;31(2):95-107doi: 10.1016/j.tcb.2020.11.001.
Odle, R. I., Florey, O., Ktistakis, N. T., & Cook, S. J. (2021). CDK1, the Other 'Master Regulator' of Autophagy. Trends in cell biology, 31(2), 95-107. https://doi.org/10.1016/j.tcb.2020.11.001
Odle, Richard I, et al. "CDK1, the Other 'Master Regulator' of Autophagy." Trends in cell biology vol. 31,2 (2021): 95-107. doi: https://doi.org/10.1016/j.tcb.2020.11.001
Odle RI, Florey O, Ktistakis NT, Cook SJ. CDK1, the Other 'Master Regulator' of Autophagy. Trends Cell Biol. 2021 Feb;31(2):95-107. doi: 10.1016/j.tcb.2020.11.001. Epub 2020 Nov 30. PMID: 33272830.
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Trends Cell Biol. 2021 Feb;31(2):95-107. doi: 10.1016/j.tcb.2020.11.001. Epub 2020 Nov 30.

CDK1, the Other 'Master Regulator' of Autophagy.

Trends in cell biology

Richard I Odle, Oliver Florey, Nicholas T Ktistakis, Simon J Cook

Affiliations

  1. Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.
  2. Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK. Electronic address: [email protected].

PMID: 33272830 DOI: 10.1016/j.tcb.2020.11.001

Abstract

Autophagy and cap-dependent mRNA translation are tightly regulated by the mechanistic target of rapamycin complex 1 (mTORC1) signalling complex in response to nutrient availability. However, the regulation of these processes, and mTORC1 itself, is different during mitosis, and this has remained an area of significant controversy; for example, studies have argued that autophagy is either repressed or highly active during mitosis. Recent studies have shown that autophagy initiation is repressed, and cap-dependent mRNA translation is maintained during mitosis despite mTORC1 activity being repressed. This is achieved in large part by a switch from mTORC1- to cyclin-dependent kinase 1 (CDK1)-mediated regulation. Here, we review the history and recent advances and seek to present a unifying model to inform the future study of autophagy and mTORC1 during mitosis.

Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

Keywords: CDK1; autophagy; mTORC1; mitosis; translation

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