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Hepkema JT, Poelmann FB, Gouw ASH, et al. Malignant Transformation of an HNF1a-Inactivated Hepatocellular Adenoma to Hepatocellular Carcinoma. Case Rep Gastroenterol. 2020;14(3):577-585doi: 10.1159/000510215.
Hepkema, J. T., Poelmann, F. B., Gouw, A. S. H., de Haas, R. J., Duiker, E. W., Blokzijl, H., & Klaase, J. M. (2020). Malignant Transformation of an HNF1a-Inactivated Hepatocellular Adenoma to Hepatocellular Carcinoma. Case reports in gastroenterology, 14(3), 577-585. https://doi.org/10.1159/000510215
Hepkema, Joris T, et al. "Malignant Transformation of an HNF1a-Inactivated Hepatocellular Adenoma to Hepatocellular Carcinoma." Case reports in gastroenterology vol. 14,3 (2020): 577-585. doi: https://doi.org/10.1159/000510215
Hepkema JT, Poelmann FB, Gouw ASH, de Haas RJ, Duiker EW, Blokzijl H, Klaase JM. Malignant Transformation of an HNF1a-Inactivated Hepatocellular Adenoma to Hepatocellular Carcinoma. Case Rep Gastroenterol. 2020 Nov 02;14(3):577-585. doi: 10.1159/000510215. eCollection 2020. PMID: 33250700; PMCID: PMC7670361.
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Case Rep Gastroenterol. 2020 Nov 02;14(3):577-585. doi: 10.1159/000510215. eCollection 2020.

Malignant Transformation of an HNF1a-Inactivated Hepatocellular Adenoma to Hepatocellular Carcinoma.

Case reports in gastroenterology

Joris T Hepkema, Floris B Poelmann, Annette S H Gouw, Robbert J de Haas, Evelien W Duiker, Hans Blokzijl, Joost M Klaase

Affiliations

  1. Division of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  2. Department of Medical Biology and Pathology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  3. Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  4. Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

PMID: 33250700 PMCID: PMC7670361 DOI: 10.1159/000510215

Abstract

Hepatocellular adenomas (HCA) are rare benign tumors of the liver, occurring predominantly in females using oral contraceptives. Our case describes a 66-year-old woman presenting with a palpable mass in her upper abdomen. Contrast-enhanced computed tomography and magnetic resonance imaging showed a large exophytic mass protruding from the caudal border of liver segments IV and V, without visible metastases. Laparoscopic resection of the tumor and gallbladder was performed. Histopathological examination showed a hepatocellular carcinoma with areas of HNF1a-HCA (H-HCA). This case shows that malignant transformation is possible in H-HCA. We present our preoperative decision-making process, as well as the role of imaging techniques in this rare case.

Copyright © 2020 by S. Karger AG, Basel.

Keywords: Hepatocellular adenoma; Hepatocellular carcinoma; Hepatocyte nuclear factor 1-alpha; Imaging; Laparoscopy; Surgical resection

Conflict of interest statement

The authors have no conflicts of interest to declare.

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