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Abdel-Megeed RM, Abd El-Alim SH, Arafa AF, et al. Crosslink among phosphatidylinositol-3 kinase/Akt, PTEN and STAT-5A signaling pathways post liposomal galactomannan hepatocellular carcinoma therapy. Toxicol Rep. 2020;7:1531-1541doi: 10.1016/j.toxrep.2020.10.018.
Abdel-Megeed, R. M., Abd El-Alim, S. H., Arafa, A. F., Matloub, A. A., Farrag, A. E. R. H., Darwish, A. B., Abdel-Hamid, A. Z., & Kadry, M. O. (2020). Crosslink among phosphatidylinositol-3 kinase/Akt, PTEN and STAT-5A signaling pathways post liposomal galactomannan hepatocellular carcinoma therapy. Toxicology reports, 71531-1541. https://doi.org/10.1016/j.toxrep.2020.10.018
Abdel-Megeed, Rehab M, et al. "Crosslink among phosphatidylinositol-3 kinase/Akt, PTEN and STAT-5A signaling pathways post liposomal galactomannan hepatocellular carcinoma therapy." Toxicology reports vol. 7 (2020): 1531-1541. doi: https://doi.org/10.1016/j.toxrep.2020.10.018
Abdel-Megeed RM, Abd El-Alim SH, Arafa AF, Matloub AA, Farrag AERH, Darwish AB, Abdel-Hamid AZ, Kadry MO. Crosslink among phosphatidylinositol-3 kinase/Akt, PTEN and STAT-5A signaling pathways post liposomal galactomannan hepatocellular carcinoma therapy. Toxicol Rep. 2020 Nov 05;7:1531-1541. doi: 10.1016/j.toxrep.2020.10.018. eCollection 2020. PMID: 33251120; PMCID: PMC7683274.
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Toxicol Rep. 2020 Nov 05;7:1531-1541. doi: 10.1016/j.toxrep.2020.10.018. eCollection 2020.

Crosslink among phosphatidylinositol-3 kinase/Akt, PTEN and STAT-5A signaling pathways post liposomal galactomannan hepatocellular carcinoma therapy.

Toxicology reports

Rehab M Abdel-Megeed, Sameh H Abd El-Alim, Azza F Arafa, Azza A Matloub, Abd El Razik H Farrag, Asmaa B Darwish, Abdel-Hamid Z Abdel-Hamid, Mai O Kadry

Affiliations

  1. Therapeutic Chemistry Department, National Research Centre, El-Buhouth St., Cairo, 12622, Egypt.
  2. Pharmaceutical Technology Department, National Research Centre, El-Buhouth St., Cairo, 12622, Egypt.
  3. Pharmacognosy D Department, National Research Centre, El-Buhouth St., Cairo, 12622, Egypt.
  4. Pathology Department, National Research Centre, El-Buhouth St., Cairo, 12622, Egypt.

PMID: 33251120 PMCID: PMC7683274 DOI: 10.1016/j.toxrep.2020.10.018

Abstract

Liposomal drug-delivery systems (LDDs) provide a promising opportunity to precisely target organs, improve drug bioavailability and reduce systemic toxicity. On the other hand, PI

© 2020 The Authors.

Keywords: AFP, α-fetoprotein; ALP, alkaline phasphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; Akt, serine/threonine kinase; Bad, Bcl-2-associated death promoter; C. gilliesii, Caesalpinia gilliesii; CCl4, carbon tetrachloride; DDs, drug-delivery systems; DEN, diethylnitrosamine; FOXO1, fork-head box protein O1; GM, galactomannan; GSH, glutathione; GSK3, glycogen synthase kinase; GST, glutathione S-transferase; HCC, hepatocellular carcinoma; Hepatocellular carcinoma; LDDs, liposomal drug-delivery systems; LPs, liposomes; Liposomal galactomannan; PI3K, phosphoinositide 3-kinase; PI3K/Akt; PIP2, phosphatidylinositol bisphosphate; PIP3, phosphatidylinositol trisphosphate; PTEN; PTEN, phosphatase and tensin homolog; STAT 5A; STAT-5A, signal transducer and activator of transcription-5A; TEM, transmission electron microscopy; VS, vesicle size

Conflict of interest statement

No conflict of interest has been declared.

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