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Carbajal-García A, Reyes-García J, Montaño LM. Androgen Effects on the Adrenergic System of the Vascular, Airway, and Cardiac Myocytes and Their Relevance in Pathological Processes. Int J Endocrinol. 2020;2020:8849641doi: 10.1155/2020/8849641.
Carbajal-García, A., Reyes-García, J., & Montaño, L. M. (2020). Androgen Effects on the Adrenergic System of the Vascular, Airway, and Cardiac Myocytes and Their Relevance in Pathological Processes. International journal of endocrinology, 20208849641. https://doi.org/10.1155/2020/8849641
Carbajal-García, Abril, et al. "Androgen Effects on the Adrenergic System of the Vascular, Airway, and Cardiac Myocytes and Their Relevance in Pathological Processes." International journal of endocrinology vol. 2020 (2020): 8849641. doi: https://doi.org/10.1155/2020/8849641
Carbajal-García A, Reyes-García J, Montaño LM. Androgen Effects on the Adrenergic System of the Vascular, Airway, and Cardiac Myocytes and Their Relevance in Pathological Processes. Int J Endocrinol. 2020 Nov 12;2020:8849641. doi: 10.1155/2020/8849641. eCollection 2020. PMID: 33273918; PMCID: PMC7676939.
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Int J Endocrinol. 2020 Nov 12;2020:8849641. doi: 10.1155/2020/8849641. eCollection 2020.

Androgen Effects on the Adrenergic System of the Vascular, Airway, and Cardiac Myocytes and Their Relevance in Pathological Processes.

International journal of endocrinology

Abril Carbajal-García, Jorge Reyes-García, Luis M Montaño

Affiliations

  1. Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, CDMX, Mexico.

PMID: 33273918 PMCID: PMC7676939 DOI: 10.1155/2020/8849641

Abstract

INTRODUCTION: Androgen signaling comprises nongenomic and genomic pathways. Nongenomic actions are not related to the binding of the androgen receptor (AR) and occur rapidly. The genomic effects implicate the binding to a cytosolic AR, leading to protein synthesis. Both events are independent of each other. Genomic effects have been associated with different pathologies such as vascular ischemia, hypertension, asthma, and cardiovascular diseases. Catecholamines play a crucial role in regulating vascular smooth muscle (VSM), airway smooth muscle (ASM), and cardiac muscle (CM) function and tone.

OBJECTIVE: The aim of this review is an updated analysis of the role of androgens in the adrenergic system of vascular, airway, and cardiac myocytes.

CONCLUSIONS: Androgens play an essential role in the adrenergic system of vascular, airway, and cardiac myocytes, favoring either a state of health or disease. While the use of androgens as a therapeutic tool for treating asthma symptoms or heart disease is proposed, the vascular system is warmly affected.

Copyright © 2020 Abril Carbajal-García et al.

Conflict of interest statement

The authors declare that they have no conflicts of interest.

References

  1. J Biol Chem. 1997 May 30;272(22):14057-61 - PubMed
  2. Sci Rep. 2018 Jan 17;8(1):994 - PubMed
  3. Cancer Res. 2005 Dec 15;65(24):11287-91 - PubMed
  4. J Clin Invest. 1996 Jul 15;98(2):556-62 - PubMed
  5. J Cereb Blood Flow Metab. 2015 Sep;35(9):1537-46 - PubMed
  6. Am J Physiol. 1997 Aug;273(2 Pt 1):C500-8 - PubMed
  7. Am J Respir Crit Care Med. 2004 Aug 1;170(3):296-305 - PubMed
  8. Curr Opin Cell Biol. 1991 Dec;3(6):1025-32 - PubMed
  9. Circulation. 1999 Nov 30;100(22):2210-2 - PubMed
  10. Dis Markers. 2013;35(2):85-96 - PubMed
  11. Mol Cell Endocrinol. 2017 Jan 5;439:444-456 - PubMed
  12. Clin Exp Pharmacol Physiol. 2007 Sep;34(9):884-8 - PubMed
  13. Ageing Res Rev. 2003 Apr;2(2):169-90 - PubMed
  14. Eur J Endocrinol. 2015 Feb;172(2):R79-91 - PubMed
  15. Eur J Pharmacol. 2008 Dec 28;601(1-3):154-62 - PubMed
  16. PLoS One. 2019 May 13;14(5):e0216951 - PubMed
  17. Arch Med Res. 1999 Jul-Aug;30(4):290-7 - PubMed
  18. Respiration. 1986;50 Suppl 2:9-16 - PubMed
  19. Clin Exp Pharmacol Physiol. 2013 Mar;40(3):181-9 - PubMed
  20. Front Pharmacol. 2019 Apr 16;10:336 - PubMed
  21. Endocr Res. 2018 Aug;43(3):166-175 - PubMed
  22. Drugs Aging. 1995 Oct;7(4):278-91 - PubMed
  23. Respir Med. 2000 May;94(5):454-65 - PubMed
  24. Circ Res. 2001 Aug 17;89(4):343-50 - PubMed
  25. Annu Rev Pharmacol Toxicol. 1994;34:117-33 - PubMed
  26. J Pharmacol Exp Ther. 2019 Jul;370(1):104-110 - PubMed
  27. Mol Endocrinol. 2015 Dec;29(12):1759-73 - PubMed
  28. Science. 2002 May 31;296(5573):1636-9 - PubMed
  29. FASEB J. 2008 Jul;22(7):2134-41 - PubMed
  30. Br J Pharmacol. 2015 Dec;172(23):5444-56 - PubMed
  31. Am J Physiol Heart Circ Physiol. 2019 Aug 1;317(2):H243-H254 - PubMed
  32. Endocr Rev. 2017 Jun 1;38(3):220-254 - PubMed
  33. Cell Calcium. 2007 May;41(5):467-77 - PubMed
  34. Br J Pharmacol. 2006 Dec;149(8):1083-91 - PubMed
  35. Horm Res. 2005;63(1):6-14 - PubMed
  36. Heart Rhythm. 2011 May;8(5):739 - PubMed
  37. Microcirculation. 2018 Jan;25(1): - PubMed
  38. Am J Med. 2007 Oct;120(10):835-40 - PubMed
  39. J Clin Invest. 2002 Mar;109(6):765-75 - PubMed
  40. Fertil Steril. 2002 Apr;77 Suppl 4:S3-5 - PubMed
  41. Naunyn Schmiedebergs Arch Pharmacol. 2003 Oct;368(4):277-83 - PubMed
  42. Endocrinology. 2014 Nov;155(11):4250-65 - PubMed
  43. Cancer Res. 2009 Jan 1;69(1):16-22 - PubMed
  44. J Am Coll Cardiol. 2016 Aug 2;68(5):574-575 - PubMed
  45. Contemp Clin Trials. 2009 Mar;30(2):133-40 - PubMed
  46. J Physiol. 2000 Nov 1;528(Pt 3):561-71 - PubMed
  47. Eur J Pharmacol. 2019 Apr 5;848:70-79 - PubMed
  48. Br J Pharmacol. 2009 Dec;158(7):1663-75 - PubMed
  49. Crit Rev Biochem Mol Biol. 1990;25(4):225-44 - PubMed
  50. Endocr Rev. 2012 Feb;33(1):1-47 - PubMed
  51. Circ Res. 1974 Dec;35(6):835-49 - PubMed
  52. Int J Mol Med. 2018 Dec;42(6):2998-3008 - PubMed
  53. J Endocr Soc. 2019 Apr 04;3(5):1087-1096 - PubMed
  54. Int J Cardiol. 2003 Jan;87(1):53-7 - PubMed
  55. J Cardiovasc Pharmacol. 1984 Sep-Oct;6(5):961-8 - PubMed
  56. Cell Mol Neurobiol. 2018 Jan;38(1):109-120 - PubMed
  57. J Biol Chem. 2010 Dec 17;285(51):39953-64 - PubMed
  58. Eur Heart J. 2000 Jun;21(11):890-4 - PubMed
  59. J Hypertens. 2002 Nov;20(11):2139-40 - PubMed
  60. Hypertension. 2001 May;37(5):1199-208 - PubMed
  61. J Clin Invest. 2006 Apr;116(4):1005-15 - PubMed
  62. J Biol Chem. 1990 Aug 15;265(23):13809-17 - PubMed
  63. Int J Cardiol. 2003 Feb;87(2-3):179-83 - PubMed
  64. Endocr Rev. 2007 Dec;28(7):778-808 - PubMed
  65. Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2065-2078 - PubMed
  66. J Pharm Pharmacol. 1995 Jun;47(6):510-3 - PubMed
  67. Prog Clin Biol Res. 1990;334:303-12 - PubMed
  68. Life Sci. 2007 May 16;80(23):2170-2180 - PubMed
  69. Mol Cell Endocrinol. 2009 Mar 25;301(1-2):191-8 - PubMed
  70. J Cardiovasc Electrophysiol. 2002 May;13(5):493-501 - PubMed
  71. Am J Physiol Heart Circ Physiol. 2003 Jul;285(1):H369-74 - PubMed
  72. J Ayub Med Coll Abbottabad. 2004 Oct-Dec;16(4):26-8 - PubMed
  73. Ann Med. 1995 Aug;27(4):439-49 - PubMed
  74. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11589-94 - PubMed
  75. Circ Res. 2003 Nov 14;93(10):896-906 - PubMed
  76. Br J Pharmacol. 2009 Feb;156(4):545-62 - PubMed
  77. Circulation. 1998 Jul 21;98(3):256-61 - PubMed
  78. Clin Rev Allergy Immunol. 2006 Oct-Dec;31(2-3):119-30 - PubMed
  79. Aging Male. 2014 Sep;17(3):155-60 - PubMed
  80. Clin Exp Hypertens. 1993 Jan;15(1):153-70 - PubMed
  81. Prog Brain Res. 2010;181:177-92 - PubMed
  82. Eur J Pharmacol. 2018 Nov 15;839:82-88 - PubMed
  83. J Mol Cell Cardiol. 2000 May;32(5):817-30 - PubMed
  84. Br J Pharmacol. 1997 Mar;120(5):819-26 - PubMed
  85. Nat New Biol. 1972 Jul 19;238(81):91-2 - PubMed
  86. Br J Pharmacol. 2008 Feb;153(4):693-709 - PubMed
  87. Br J Pharmacol. 2008 Mar;153(5):846-57 - PubMed
  88. Fertil Steril. 2017 Mar;107(3):788-795.e2 - PubMed
  89. Transl Androl Urol. 2016 Apr;5(2):207-12 - PubMed
  90. Cell Calcium. 2007 Jul;42(1):11-5 - PubMed
  91. Endocrinol Metab Clin North Am. 2013 Jun;42(2):227-53 - PubMed
  92. Circulation. 1995 Feb 15;91(4):1154-60 - PubMed
  93. J Biol Chem. 1994 Jan 28;269(4):2814-9 - PubMed
  94. Life Sci. 2018 Sep 1;208:239-245 - PubMed
  95. Clin Exp Pharmacol Physiol. 2005 Jul;32(7):503-14 - PubMed
  96. Endocrinol Metab Clin North Am. 2011 Jun;40(2):433-49, ix-x - PubMed
  97. Horm Cancer. 2014 Apr;5(2):61-71 - PubMed
  98. J Am Coll Cardiol. 2018 Jun 5;71(22):2555-2566 - PubMed
  99. Endocr Rev. 2011 Feb;32(1):81-151 - PubMed
  100. Mol Med Rep. 2018 Jun;17(6):8530-8535 - PubMed
  101. FASEB J. 2001 Dec;15(14):2718-20 - PubMed
  102. J Obstet Gynaecol Res. 2018 Jul;44(7):1193-1201 - PubMed
  103. J Hypertens. 2005 Dec;23(12):2229-36 - PubMed
  104. Med Hypotheses. 2009 Jun;72(6):723-8 - PubMed
  105. Cancer Res. 2009 Mar 15;69(6):2305-13 - PubMed
  106. Endocrinology. 2008 May;149(5):2517-26 - PubMed
  107. Oncotarget. 2017 Mar 14;8(11):18550-18576 - PubMed
  108. Biochemistry (Mosc). 2000 Jul;65(7):798-806 - PubMed
  109. Gen Comp Endocrinol. 2011 Jul 1;172(3):518-25 - PubMed
  110. Cell Physiol Biochem. 2019;53(1):215-228 - PubMed
  111. Br J Pharmacol. 1985 Jan;84(1):227-35 - PubMed
  112. J Pharmacol Exp Ther. 1989 Nov;251(2):640-4 - PubMed
  113. Endocrinology. 2016 May;157(5):1866-80 - PubMed
  114. Nat Commun. 2019 May 20;10(1):2234 - PubMed
  115. Br J Pharmacol. 1983 Feb;78(2):441-5 - PubMed
  116. J Allergy Clin Immunol. 2006 Jan;117(1):18-24; quiz 25 - PubMed
  117. Theor Biol Med Model. 2005 Feb 14;2:5 - PubMed
  118. PLoS One. 2016 Apr 21;11(4):e0154003 - PubMed
  119. Can J Physiol Pharmacol. 1994 Aug;72(8):919-36 - PubMed
  120. Can J Physiol Pharmacol. 1994 Nov;72(11):1380-5 - PubMed
  121. Pharmacol Rev. 2005 Dec;57(4):411-25 - PubMed
  122. Am J Physiol Heart Circ Physiol. 2010 Jul;299(1):H202-9 - PubMed
  123. Am J Respir Crit Care Med. 2000 Jul;162(1):68-74 - PubMed
  124. Cell Biol Int. 2015 May;39(5):584-90 - PubMed
  125. J Cardiovasc Pharmacol. 2005 Jun;45(6):580-5 - PubMed
  126. Cell Signal. 2016 Aug;28(8):1075-85 - PubMed
  127. Clin Endocrinol (Oxf). 2012 Oct;77(4):548-54 - PubMed
  128. Mol Cell Biochem. 2018 Sep;446(1-2):149-160 - PubMed
  129. J Clin Endocrinol Metab. 1986 Feb;62(2):275-9 - PubMed
  130. High Blood Press Cardiovasc Prev. 2019 Feb;26(1):1-8 - PubMed
  131. Circulation. 2006 Oct 24;114(17):1829-37 - PubMed
  132. Planta Med. 2019 Jul;85(9-10):738-744 - PubMed
  133. Front Immunol. 2017 Jun 16;8:707 - PubMed
  134. Transl Androl Urol. 2013 Sep;2(3):178-186 - PubMed
  135. Adv Immunol. 2017;136:1-28 - PubMed
  136. Mol Cell Endocrinol. 2017 Feb 5;441:62-67 - PubMed
  137. Gen Comp Endocrinol. 2018 Feb 1;257:130-136 - PubMed
  138. Circulation. 1999 Oct 19;100(16):1690-6 - PubMed
  139. J Thorac Dis. 2019 Mar;11(3):1005-1015 - PubMed
  140. Life Sci. 2011 Oct 24;89(17-18):631-7 - PubMed
  141. Pharmacol Ther. 2000 Dec;88(3):281-309 - PubMed
  142. Endocrinology. 2014 Nov;155(11):4237-49 - PubMed
  143. Br J Pharmacol. 2001 Mar;132(6):1292-8 - PubMed
  144. Mayo Clin Proc. 2018 Jan;93(1):83-100 - PubMed
  145. Annu Rev Physiol. 2009;71:1-18 - PubMed
  146. Circulation. 1996 Nov 15;94(10):2614-9 - PubMed
  147. Endocrinology. 2003 Oct;144(10):4478-83 - PubMed
  148. Arch Invest Med (Mex). 1985 Apr-Jun;16(2):169-74 - PubMed
  149. J Gen Physiol. 2017 Sep 4;149(9):867-875 - PubMed
  150. Curr Atheroscler Rep. 2018 Feb 14;20(3):13 - PubMed
  151. Am J Physiol Lung Cell Mol Physiol. 2019 Sep 1;317(3):L369-L380 - PubMed
  152. J Gerontol A Biol Sci Med Sci. 2003 May;58(5):M409-16 - PubMed
  153. Steroids. 1999 Nov;64(11):753-9 - PubMed
  154. Circ Heart Fail. 2009 Nov;2(6):654-63 - PubMed
  155. Nature. 1997 Nov 6;390(6655):88-91 - PubMed
  156. Life Sci. 2008 Oct 10;83(15-16):569-73 - PubMed
  157. Front Horm Res. 2009;37:183-196 - PubMed
  158. Circulation. 2002 Apr 9;105(14):1700-7 - PubMed
  159. Circulation. 2005 Mar 15;111(10):1242-9 - PubMed
  160. Am J Respir Crit Care Med. 1995 Oct;152(4 Pt 1):1183-8 - PubMed
  161. Pharmacol Ther. 2004 Jan;101(1):65-74 - PubMed
  162. FASEB J. 1992 Feb 1;6(3):832-9 - PubMed
  163. Mol Cell Endocrinol. 2018 Apr 15;465:4-26 - PubMed
  164. Hypertension. 2007 Jun;49(6):1442-7 - PubMed
  165. Chem Res Toxicol. 2003 Oct;16(10):1338-58 - PubMed
  166. Arch Intern Med. 1999 May 24;159(10):1061-6 - PubMed
  167. Cardiovasc J S Afr. 2005 Jan-Feb;16(1):21-8 - PubMed
  168. J Physiol. 1998 Dec 15;513 ( Pt 3):711-8 - PubMed
  169. Annu Rev Biochem. 1994;63:25-61 - PubMed
  170. Nutr Metab Cardiovasc Dis. 2012 Apr;22(4):340-6 - PubMed
  171. J Pharmacol Exp Ther. 2002 Oct;303(1):247-56 - PubMed
  172. J Endocrinol. 2014 Jul;222(1):1-13 - PubMed
  173. J Appl Physiol Respir Environ Exerc Physiol. 1978 Aug;45(2):307-11 - PubMed
  174. BMC Syst Biol. 2017 Jun 28;11(1):65 - PubMed
  175. Drugs Aging. 1991 Mar;1(2):116-29 - PubMed
  176. J Am Coll Cardiol. 2009 Dec 15;54(25):2366-73 - PubMed
  177. Channels (Austin). 2014;8(5):402-13 - PubMed
  178. Front Immunol. 2017 Aug 31;8:1069 - PubMed
  179. J Clin Endocrinol Metab. 2013 Dec;98(12):4565-92 - PubMed
  180. Cardiovasc Res. 2006 Sep 1;71(4):735-43 - PubMed
  181. Andrologia. 2013 Jun;45(3):187-94 - PubMed
  182. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1516-20 - PubMed
  183. Am J Physiol. 1997 Sep;273(3 Pt 2):H1611-8 - PubMed
  184. J Steroid Biochem Mol Biol. 2020 Feb;196:105496 - PubMed
  185. J Clin Endocrinol Metab. 1999 May;84(5):1685-9 - PubMed
  186. Int J Mol Sci. 2014 Sep 01;15(9):15412-25 - PubMed
  187. J Strength Cond Res. 2007 May;21(2):354-61 - PubMed
  188. Pharmacol Rev. 2001 Jun;53(2):319-56 - PubMed
  189. J Clin Invest. 1991 Aug;88(2):385-9 - PubMed
  190. Nat Immunol. 2015 Jan;16(1):45-56 - PubMed
  191. J Cardiovasc Pharmacol Ther. 2011 Mar;16(1):14-23 - PubMed
  192. Circulation. 2000 Oct 17;102(16):1906-11 - PubMed
  193. Basic Res Cardiol. 2017 May;112(3):29 - PubMed
  194. Blood. 2001 Dec 1;98(12):3353-8 - PubMed
  195. Anesthesiology. 2003 Oct;99(4):889-95 - PubMed
  196. Circulation. 2005 Jun 28;111(25):3420-8 - PubMed
  197. J Cardiovasc Pharmacol. 1987;10 Suppl 1:S82-8 - PubMed
  198. Circulation. 2018 Jul 10;138(2):198-205 - PubMed
  199. Cardiovasc Res. 2005 Jan 1;65(1):148-57 - PubMed
  200. Anat Rec. 2000 Aug 1;259(4):353-82 - PubMed
  201. Int J Mol Sci. 2018 Jul 30;19(8): - PubMed
  202. Metabolism. 2008 Jul;57(7):961-5 - PubMed
  203. Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):512-5 - PubMed
  204. Physiol Rev. 1998 Oct;78(4):921-47 - PubMed
  205. Eur J Pharmacol. 2004 Jan 26;484(2-3):287-90 - PubMed
  206. Semin Surg Oncol. 1990;6(2):83-90 - PubMed
  207. Am J Physiol Regul Integr Comp Physiol. 2012 Feb 1;302(3):R357-64 - PubMed
  208. EMBO J. 1991 Dec;10(12):3721-7 - PubMed
  209. Mol Cell Endocrinol. 2020 Jun 15;510:110801 - PubMed
  210. Trends Pharmacol Sci. 1994 Oct;15(10):370-4 - PubMed
  211. Am J Physiol Heart Circ Physiol. 2003 Apr;284(4):H1104-9 - PubMed
  212. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3589-93 - PubMed
  213. Cold Spring Harb Perspect Biol. 2015 Feb 02;7(2):a006023 - PubMed
  214. Br J Pharmacol. 2002 Feb;135(3):735-40 - PubMed
  215. Atherosclerosis. 2012 Sep;224(1):228-34 - PubMed
  216. J Clin Endocrinol Metab. 2000 Jul;85(7):2519-25 - PubMed
  217. Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10140-5 - PubMed
  218. Endocrinology. 2006 Mar;147(3):1386-95 - PubMed
  219. Pflugers Arch. 2011 Oct;462(4):573-85 - PubMed
  220. Eur J Endocrinol. 2001 Oct;145(4):457-61 - PubMed
  221. J Pharm Pharmacol. 1969 Feb;21(2):97-102 - PubMed
  222. Nature. 1993 Jan 28;361(6410):315-25 - PubMed
  223. Circ Res. 1987 Oct;61(4 Pt 2):I10-6 - PubMed
  224. Gen Pharmacol. 1996 Jan;27(1):181-5 - PubMed
  225. Am J Respir Cell Mol Biol. 2009 Jun;40(6):663-71 - PubMed
  226. PLoS One. 2019 May 14;14(5):e0216908 - PubMed
  227. J Mol Cell Cardiol. 2014 Mar;68:66-74 - PubMed
  228. Mol Endocrinol. 2002 Oct;16(10):2181-7 - PubMed
  229. Clin Sci (Lond). 2005 Nov;109(5):431-7 - PubMed
  230. FASEB J. 1989 Sep;3(11):2266-76 - PubMed
  231. Front Physiol. 2013 Nov 28;4:348 - PubMed
  232. FEBS J. 2005 Jan;272(1):74-84 - PubMed
  233. Anesthesiology. 1994 Nov;81(5):1235-44 - PubMed
  234. J Appl Physiol (1985). 2017 Oct 1;123(4):717-727 - PubMed
  235. Curr Hypertens Rep. 2017 May;19(5):44 - PubMed
  236. Int J Endocrinol. 2016;2016:8423192 - PubMed
  237. Life Sci. 2013 May 30;92(20-21):1029-35 - PubMed
  238. Am J Physiol. 1970 Feb;218(2):596-9 - PubMed
  239. J Clin Endocrinol Metab. 2001 Nov;86(11):5121-6 - PubMed
  240. PLoS One. 2016 Apr 01;11(4):e0152005 - PubMed
  241. Endocrinology. 2000 Aug;141(8):2786-94 - PubMed
  242. N Engl J Med. 2005 Mar 24;352(12):1223-36 - PubMed
  243. J Hypertens. 2018 Apr;36(4):768-770 - PubMed
  244. Hypertension. 1999 Dec;34(6):1232-6 - PubMed
  245. Prog Mol Biol Transl Sci. 2019;161:91-112 - PubMed
  246. Am J Physiol Cell Physiol. 2009 Apr;296(4):C766-82 - PubMed
  247. J Physiol. 2000 Feb 15;523 Pt 1:131-8 - PubMed
  248. Nat Rev Immunol. 2015 Jan;15(1):57-65 - PubMed
  249. J Cardiovasc Pharmacol. 1990;16 Suppl 5:S105-12 - PubMed
  250. Adv Exp Med Biol. 2019;1124:381-422 - PubMed
  251. Endocrinology. 2006 Nov;147(11):5160-9 - PubMed
  252. Mol Pharmacol. 2013 May;83(5):939-48 - PubMed
  253. Handb Exp Pharmacol. 2017;237:23-40 - PubMed
  254. Eur Heart J. 2003 May;24(10):909-15 - PubMed
  255. J Immunol. 2007 Oct 1;179(7):4829-39 - PubMed
  256. Asian J Androl. 2015 May-Jun;17(3):439-40 - PubMed
  257. Peptides. 1993 Mar-Apr;14(2):191-202 - PubMed
  258. Eur J Pharmacol. 2019 Jul 15;855:305-320 - PubMed
  259. Life Sci. 2007 Sep 1;81(12):993-1002 - PubMed
  260. J Physiol Sci. 2018 Nov;68(6):759-767 - PubMed
  261. Eur J Pharmacol. 2014 Oct 5;740:733-41 - PubMed
  262. Am J Physiol. 1996 Jul;271(1 Pt 1):L100-5 - PubMed
  263. Nat Genet. 1994 May;7(1):34-9 - PubMed
  264. Anesth Prog. 2015 Spring;62(1):31-9 - PubMed
  265. J Pharmacol Exp Ther. 2001 Aug;298(2):441-52 - PubMed
  266. Curr Pharm Biotechnol. 2011 Feb 1;12(2):275-84 - PubMed
  267. J Biol Chem. 1996 May 31;271(22):13239-43 - PubMed
  268. Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1596-603 - PubMed
  269. J Steroid Biochem Mol Biol. 2013 Nov;138:174-82 - PubMed
  270. Mol Cell Endocrinol. 2018 Sep 15;473:17-30 - PubMed
  271. Mol Pharmacol. 2019 May;95(5):563-572 - PubMed
  272. Br J Pharmacol. 2003 Jul;139(6):1203-11 - PubMed
  273. Biochem Biophys Res Commun. 2019 May 14;512(4):908-913 - PubMed
  274. Circ Res. 1999 Jun 11;84(11):1285-91 - PubMed
  275. Am Heart J. 1978 Jan;95(1):43-51 - PubMed
  276. Br J Pharmacol. 1986 May;88(1):41-9 - PubMed
  277. Adv Pharmacol. 2017;78:49-87 - PubMed
  278. Nature. 1994 Nov 17;372(6503):231-6 - PubMed
  279. J Biol Chem. 2005 Dec 2;280(48):40201-9 - PubMed
  280. J Clin Endocrinol Metab. 1974 Aug;39(2):340-6 - PubMed
  281. Biochem Pharmacol. 2018 Jul;153:91-122 - PubMed
  282. Hypertension. 2000 Jan;35(1 Pt 2):173-8 - PubMed
  283. J Biol Chem. 2001 Apr 27;276(17):13738-43 - PubMed
  284. Endocr Relat Cancer. 2011 Sep 20;18(5):R183-96 - PubMed
  285. J Physiol. 1994 Apr 15;476(2):279-93 - PubMed
  286. Science. 1996 Aug 9;273(5276):803-5 - PubMed
  287. Endocr J. 2005 Feb;52(1):111-5 - PubMed
  288. Sports Med. 2004;34(8):513-54 - PubMed
  289. Naunyn Schmiedebergs Arch Pharmacol. 1999 Aug;360(2):165-70 - PubMed
  290. Circulation. 1991 Nov;84(5):2108-22 - PubMed
  291. Drug Discov Today. 2012 Sep;17(17-18):974-87 - PubMed
  292. J Cardiovasc Pharmacol. 2018 Mar;71(3):147-154 - PubMed
  293. J Clin Endocrinol Metab. 1986 Feb;62(2):331-5 - PubMed
  294. Clin Sci (Lond). 2017 Jul 1;131(13):1405-1418 - PubMed
  295. PLoS One. 2014 Oct 08;9(10):e109346 - PubMed
  296. Pharmacol Res. 2006 Dec;54(6):468-73 - PubMed
  297. Physiol Genomics. 2002;9(2):85-91 - PubMed
  298. Am J Physiol. 1996 Dec;271(6 Pt 2):H2313-9 - PubMed
  299. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10775-80 - PubMed
  300. Endocr Rev. 2002 Apr;23(2):175-200 - PubMed
  301. Horm Metab Res. 2004 Apr;36(4):197-202 - PubMed
  302. Cell. 2000 May 12;101(4):365-76 - PubMed
  303. Am J Physiol Heart Circ Physiol. 2001 Oct;281(4):H1720-7 - PubMed
  304. Clin Endocrinol (Oxf). 2012 Nov;77(5):755-63 - PubMed
  305. Biochemistry. 1999 Aug 10;38(32):10361-70 - PubMed
  306. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1607-12 - PubMed
  307. J Biol Chem. 1993 Jul 25;268(21):15374-80 - PubMed
  308. J Immunol. 2018 Oct 1;201(7):1843-1854 - PubMed
  309. Pflugers Arch. 2015 Apr;467(4):767-77 - PubMed
  310. Biochim Biophys Acta. 2007 Aug;1773(8):1285-98 - PubMed
  311. FASEB J. 2002 Oct;16(12):1537-49 - PubMed
  312. Clin Exp Hypertens. 1994 Sep;16(5):611-25 - PubMed
  313. Br J Pharmacol. 1995 Jul;115(6):981-6 - PubMed
  314. Int J Mol Sci. 2018 Jan 02;19(1): - PubMed
  315. Circ Res. 1993 Nov;73(5):820-8 - PubMed
  316. J Steroid Biochem Mol Biol. 2019 Sep;192:105386 - PubMed
  317. Endocr Rev. 1980 Spring;1(2):132-9 - PubMed
  318. Naunyn Schmiedebergs Arch Pharmacol. 1983 Nov;324(3):196-200 - PubMed
  319. Auton Neurosci. 2016 Aug;199:3-16 - PubMed
  320. Endocrinology. 2012 Oct;153(10):4608-15 - PubMed
  321. Reg Anesth Pain Med. 2014 Mar-Apr;39(2):133-6 - PubMed
  322. J Mol Cell Cardiol. 2011 Oct;51(4):518-28 - PubMed
  323. J Allergy Clin Immunol. 1988 Mar;81(3):509-17 - PubMed

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