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Vlachakis D, Papageorgiou L, Papadaki A, et al. An updated evolutionary study of the Notch family reveals a new ancient origin and novel invariable motifs as potential pharmacological targets. PeerJ. 2020;8:e10334doi: 10.7717/peerj.10334.
Vlachakis, D., Papageorgiou, L., Papadaki, A., Georga, M., Kossida, S., & Eliopoulos, E. (2020). An updated evolutionary study of the Notch family reveals a new ancient origin and novel invariable motifs as potential pharmacological targets. PeerJ, 8e10334. https://doi.org/10.7717/peerj.10334
Vlachakis, Dimitrios, et al. "An updated evolutionary study of the Notch family reveals a new ancient origin and novel invariable motifs as potential pharmacological targets." PeerJ vol. 8 (2020): e10334. doi: https://doi.org/10.7717/peerj.10334
Vlachakis D, Papageorgiou L, Papadaki A, Georga M, Kossida S, Eliopoulos E. An updated evolutionary study of the Notch family reveals a new ancient origin and novel invariable motifs as potential pharmacological targets. PeerJ. 2020 Nov 05;8:e10334. doi: 10.7717/peerj.10334. eCollection 2020. PMID: 33194454; PMCID: PMC7649014.
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PeerJ. 2020 Nov 05;8:e10334. doi: 10.7717/peerj.10334. eCollection 2020.

An updated evolutionary study of the Notch family reveals a new ancient origin and novel invariable motifs as potential pharmacological targets.

PeerJ

Dimitrios Vlachakis, Louis Papageorgiou, Ariadne Papadaki, Maria Georga, Sofia Kossida, Elias Eliopoulos

Affiliations

  1. Laboratory of Genetics, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, Athens, Greece.
  2. University Research Institute of Maternal and Child Health & Precision Medicine, and UNESCO Chair on Adolescent Health Care, "Aghia Sophia" Children's Hospital, National and Kapodistrian University of Athens, Athens, Greece.
  3. Division of Endocrinology and Metabolism, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
  4. Department of Informatics and Telecommunications, National and Kapodistrian University of Athens, Athens, Greece.
  5. IMGT, The International ImMunoGeneTics Information System, Université de Montpellier, Laboratoire d'ImmunoGénétique Moléculaire and Institut de Génétique Humaine, University of Montpellier, Montpellier, France.

PMID: 33194454 PMCID: PMC7649014 DOI: 10.7717/peerj.10334

Abstract

Notch family proteins play a key role in a variety of developmental processes by controlling cell fate decisions and operating in a great number of biological processes in several organ systems, such as hematopoiesis, somatogenesis, vasculogenesis, neurogenesis and homeostasis. The Notch signaling pathway is crucial for the majority of developmental programs and regulates multiple pathogenic processes. Notch family receptors' activation has been largely related to its multiple effects in sustaining oncogenesis. The Notch signaling pathway constitutes an ancient and conserved mechanism for cell to cell communication. Much of what is known about Notch family proteins function comes from studies done in

© 2020 Vlachakis et al.

Keywords: Developmental processes; Evolutionary analysis; Notch family; Notch signaling pathway; Pharmacological target

Conflict of interest statement

The authors declare that they have no competing interests.

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