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Abdulla S, Hussain A, Azim D, et al. COVID-19-Induced Hepatic Injury: A Systematic Review and Meta-Analysis. Cureus. 2020;12(10):e10923doi: 10.7759/cureus.10923.
Abdulla, S., Hussain, A., Azim, D., Abduallah, E. H., Elawamy, H., Nasim, S., Kumar, S., & Naveed, H. (2020). COVID-19-Induced Hepatic Injury: A Systematic Review and Meta-Analysis. Cureus, 12(10), e10923. https://doi.org/10.7759/cureus.10923
Abdulla, Sara, et al. "COVID-19-Induced Hepatic Injury: A Systematic Review and Meta-Analysis." Cureus vol. 12,10 (2020): e10923. doi: https://doi.org/10.7759/cureus.10923
Abdulla S, Hussain A, Azim D, Abduallah EH, Elawamy H, Nasim S, Kumar S, Naveed H. COVID-19-Induced Hepatic Injury: A Systematic Review and Meta-Analysis. Cureus. 2020 Oct 13;12(10):e10923. doi: 10.7759/cureus.10923. PMID: 33194489; PMCID: PMC7657443.
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Cureus. 2020 Oct 13;12(10):e10923. doi: 10.7759/cureus.10923.

COVID-19-Induced Hepatic Injury: A Systematic Review and Meta-Analysis.

Cureus

Sara Abdulla, Azhar Hussain, Dua Azim, Enas H Abduallah, Hayam Elawamy, Sundus Nasim, Sohail Kumar, Hassan Naveed

Affiliations

  1. Biochemistry, University of Benghazi, Benghazi, LBY.
  2. Healthcare Administration, Franklin University, Columbus, USA.
  3. Medicine, Xavier University School of Medicine, Oranjestad, ABW.
  4. Internal Medicine, Dow Medical College, Dr. Ruth K. M. Pfau Civil Hospital, Karachi, PAK.
  5. Mathematics, University of Tobruk, Tobruk, LBY.
  6. Medical Laboratory, College of Medical Technology, Benghazi, LBY.
  7. Internal Medicine, St. Matthew's University School of Medicine, Grand Cayman, CYM.

PMID: 33194489 PMCID: PMC7657443 DOI: 10.7759/cureus.10923

Abstract

Background The current pandemic of the novel coronavirus disease (COVID-19) is a global health challenge. Pulmonary dysfunction is the main outcome of COVID-19 infection. In critically ill patients, however, liver complications have also been reported. Thus, we conducted a systematic review and meta-analysis to draw generalized conclusions regarding impaired liver biochemistry and its potential relationship with COVID-19 disease severity. Materials and Methods We searched the PubMed, Scopus, and Web of Science databases for all the related literature published up to June 20, 2020. The data were analyzed using R statistical software. A random-effects model was employed for pooling the data. The risk of bias and quality of included studies was assessed using the modified Newcastle-Ottawa Scale (NOS) for cohort studies. Results The present meta-analysis comprises 10 retrospective and two prospective studies (6,976 COVID-19 patients). The serum analysis revealed significantly higher levels of alanine aminotransferases and aspartate aminotransferases and significantly lower albumin levels. Moreover, insignificant increases in serum levels of total bilirubin were observed. Upon subgroup analysis of six studies (severe cases, n=131; non-severe cases, n=334) stratified on the basis of disease severity, we found that these abnormalities were relatively higher in severe cases of COVID-19 (albumin [weighted mean difference (WMD), 34.03 g/L; 95% CI, 27.42 to 40.63; p<0.0001; I

Copyright © 2020, Abdulla et al.

Keywords: covid-19; hepatic injury; lfts; liver injury; liver injury biomarkers; sars-cov-2; systematic review and meta-analysis

Conflict of interest statement

The authors have declared that no competing interests exist.

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