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Nouri P, Götz S, Rauser B, et al. Dose-Dependent and Subset-Specific Regulation of Midbrain Dopaminergic Neuron Differentiation by LEF1-Mediated WNT1/b-Catenin Signaling. Front Cell Dev Biol. 2020;8:587778doi: 10.3389/fcell.2020.587778.
Nouri, P., Götz, S., Rauser, B., Irmler, M., Peng, C., Trümbach, D., Kempny, C., Lechermeier, C. G., Bryniok, A., Dlugos, A., Euchner, E., Beckers, J., Brodski, C., Klümper, C., Wurst, W., & Prakash, N. (2020). Dose-Dependent and Subset-Specific Regulation of Midbrain Dopaminergic Neuron Differentiation by LEF1-Mediated WNT1/b-Catenin Signaling. Frontiers in cell and developmental biology, 8587778. https://doi.org/10.3389/fcell.2020.587778
Nouri, Parivash, et al. "Dose-Dependent and Subset-Specific Regulation of Midbrain Dopaminergic Neuron Differentiation by LEF1-Mediated WNT1/b-Catenin Signaling." Frontiers in cell and developmental biology vol. 8 (2020): 587778. doi: https://doi.org/10.3389/fcell.2020.587778
Nouri P, Götz S, Rauser B, Irmler M, Peng C, Trümbach D, Kempny C, Lechermeier CG, Bryniok A, Dlugos A, Euchner E, Beckers J, Brodski C, Klümper C, Wurst W, Prakash N. Dose-Dependent and Subset-Specific Regulation of Midbrain Dopaminergic Neuron Differentiation by LEF1-Mediated WNT1/b-Catenin Signaling. Front Cell Dev Biol. 2020 Oct 26;8:587778. doi: 10.3389/fcell.2020.587778. eCollection 2020. PMID: 33195246; PMCID: PMC7649324.
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Front Cell Dev Biol. 2020 Oct 26;8:587778. doi: 10.3389/fcell.2020.587778. eCollection 2020.

Dose-Dependent and Subset-Specific Regulation of Midbrain Dopaminergic Neuron Differentiation by LEF1-Mediated WNT1/b-Catenin Signaling.

Frontiers in cell and developmental biology

Parivash Nouri, Sebastian Götz, Benedict Rauser, Martin Irmler, Changgeng Peng, Dietrich Trümbach, Christian Kempny, Carina G Lechermeier, Agnes Bryniok, Andrea Dlugos, Ellen Euchner, Johannes Beckers, Claude Brodski, Claudia Klümper, Wolfgang Wurst, Nilima Prakash

Affiliations

  1. Laboratory of Applied Genetics and Stem Cell Biology, Department Hamm 2, Hamm-Lippstadt University of Applied Sciences, Hamm, Germany.
  2. Institute of Developmental Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
  3. Institute of Experimental Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
  4. Advanced Institute of Translational Medicine, The First Rehabilitation Hospital of Shanghai, Tongji University School of Medicine, Tongji University, Shanghai, China.
  5. Chair of Experimental Genetics, Technical University of Munich, Munich, Germany.
  6. German Center for Diabetes Research, Neuherberg, Germany.
  7. Department of Physiology and Cell Biology, Zlotowski Center for Neuroscience, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheba, Israel.
  8. Chair of Developmental Genetics, Helmholtz Zentrum München, Technical University of Munich/Helmholtz Zentrum München, Neuherberg, Germany.
  9. German Center for Neurodegenerative Diseases, Munich, Germany.
  10. Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

PMID: 33195246 PMCID: PMC7649324 DOI: 10.3389/fcell.2020.587778

Abstract

The mesodiencephalic dopaminergic (mdDA) neurons, including the nigrostriatal subset that preferentially degenerates in Parkinson's Disease (PD), strongly depend on an accurately balanced Wingless-type MMTV integration site family member 1 (WNT1)/beta-catenin signaling pathway during their development. Loss of this pathway abolishes the generation of these neurons, whereas excessive WNT1/b-catenin signaling prevents their correct differentiation. The identity of the cells responding to this pathway in the developing mammalian ventral midbrain (VM) as well as the precise progression of WNT/b-catenin action in these cells are still unknown. We show that strong WNT/b-catenin signaling inhibits the differentiation of WNT/b-catenin-responding mdDA progenitors into PITX3

Copyright © 2020 Nouri, Götz, Rauser, Irmler, Peng, Trümbach, Kempny, Lechermeier, Bryniok, Dlugos, Euchner, Beckers, Brodski, Klümper, Wurst and Prakash.

Keywords: Parkinson’s disease; dopamine; mouse; nerve cell; regenerative therapy

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