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Fertala A. Three Decades of Research on Recombinant Collagens: Reinventing the Wheel or Developing New Biomedical Products?. Bioengineering (Basel). 2020;7(4)doi: 10.3390/bioengineering7040155.
Fertala, A. (2020). Three Decades of Research on Recombinant Collagens: Reinventing the Wheel or Developing New Biomedical Products?. Bioengineering (Basel, Switzerland), 7(4), . https://doi.org/10.3390/bioengineering7040155
Fertala, Andrzej. "Three Decades of Research on Recombinant Collagens: Reinventing the Wheel or Developing New Biomedical Products?." Bioengineering (Basel, Switzerland) vol. 7,4 (2020). doi: https://doi.org/10.3390/bioengineering7040155
Fertala A. Three Decades of Research on Recombinant Collagens: Reinventing the Wheel or Developing New Biomedical Products?. Bioengineering (Basel). 2020 Dec 02;7(4). doi: 10.3390/bioengineering7040155. PMID: 33276472; PMCID: PMC7712652.
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Bioengineering (Basel). 2020 Dec 02;7(4). doi: 10.3390/bioengineering7040155.

Three Decades of Research on Recombinant Collagens: Reinventing the Wheel or Developing New Biomedical Products?.

Bioengineering (Basel, Switzerland)

Andrzej Fertala

Affiliations

  1. Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Curtis Building, Room 501, 1015 Walnut Street, Philadelphia, PA 19107, USA.

PMID: 33276472 PMCID: PMC7712652 DOI: 10.3390/bioengineering7040155

Abstract

Collagens provide the building blocks for diverse tissues and organs. Furthermore, these proteins act as signaling molecules that control cell behavior during organ development, growth, and repair. Their long half-life, mechanical strength, ability to assemble into fibrils and networks, biocompatibility, and abundance from readily available discarded animal tissues make collagens an attractive material in biomedicine, drug and food industries, and cosmetic products. About three decades ago, pioneering experiments led to recombinant human collagens' expression, thereby initiating studies on the potential use of these proteins as substitutes for the animal-derived collagens. Since then, scientists have utilized various systems to produce native-like recombinant collagens and their fragments. They also tested these collagens as materials to repair tissues, deliver drugs, and serve as therapeutics. Although many tests demonstrated that recombinant collagens perform as well as their native counterparts, the recombinant collagen technology has not yet been adopted by the biomedical, pharmaceutical, or food industry. This paper highlights recent technologies to produce and utilize recombinant collagens, and it contemplates their prospects and limitations.

Keywords: biomaterials; gelatin; recombinant collagen; tissue engineering

References

  1. EMBO J. 1997 Nov 17;16(22):6702-12 - PubMed
  2. J Allergy Clin Immunol. 2009 Nov;124(5):1108-10 - PubMed
  3. Dermatol Surg. 1999 Mar;25(3):195-201 - PubMed
  4. Chem Commun (Camb). 2017 Jun 22;53(51):6856-6859 - PubMed
  5. Matrix. 1993 Sep;13(5):399-405 - PubMed
  6. J Invest Dermatol. 2016 Jun;136(6):1116-1123 - PubMed
  7. Adv Drug Deliv Rev. 2003 Nov 28;55(12):1547-67 - PubMed
  8. Mar Drugs. 2020 Sep 18;18(9): - PubMed
  9. J Biomed Mater Res B Appl Biomater. 2004 Apr 15;69(1):18-24 - PubMed
  10. J Biol Chem. 2002 Aug 23;277(34):31142-53 - PubMed
  11. Tissue Eng Part A. 2013 Jul;19(13-14):1519-26 - PubMed
  12. Blood. 1994 Mar 1;83(5):1244-50 - PubMed
  13. Bioengineering (Basel). 2019 Jun 30;6(3): - PubMed
  14. Adv Exp Med Biol. 2018;1078:161-210 - PubMed
  15. Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1038-43 - PubMed
  16. Biomacromolecules. 2014 Oct 13;15(10):3540-9 - PubMed
  17. Biotechnol Prog. 2009 Nov-Dec;25(6):1660-8 - PubMed
  18. Biochem Soc Trans. 2000;28(4):350-3 - PubMed
  19. J Struct Biol. 2016 Nov;196(2):138-146 - PubMed
  20. J Biomed Mater Res A. 2018 May;106(5):1363-1372 - PubMed
  21. J Biol Chem. 2016 Feb 26;291(9):4343-55 - PubMed
  22. Sci Adv. 2020 Jun 17;6(25): - PubMed
  23. Biomater Sci. 2019 Apr 23;7(5):2191-2199 - PubMed
  24. Front Chem. 2014 Jun 23;2:40 - PubMed
  25. J Mater Chem B. 2019 May 15;7(19):3100-3108 - PubMed
  26. Infect Immun. 2000 Dec;68(12):6542-53 - PubMed
  27. PLoS One. 2017 Feb 9;12(2):e0172068 - PubMed
  28. J Mater Chem B. 2017 Aug 14;5(30):5942-5953 - PubMed
  29. J Biol Chem. 1993 Feb 15;268(5):3029-32 - PubMed
  30. Wounds. 2019 Apr;31(4):103-107 - PubMed
  31. J Biomed Mater Res B Appl Biomater. 2004 Nov 15;71(2):343-54 - PubMed
  32. Biomacromolecules. 2020 Oct 12;21(10):3997-4007 - PubMed
  33. Biopolymers. 2008 May;89(5):345-53 - PubMed
  34. Biotechnol Prog. 2016 Jan-Feb;32(1):98-107 - PubMed
  35. Acta Virol. 2017;61(3):231-239 - PubMed
  36. Transplantation. 2018 Mar;102(3):387-395 - PubMed
  37. JBJS Case Connect. 2019 Jul-Sep;9(3):e0302 - PubMed
  38. Yeast. 2001 Jun 30;18(9):797-806 - PubMed
  39. J Biol Chem. 1991 Jan 15;266(2):1117-21 - PubMed
  40. Curr Stem Cell Res Ther. 2019;14(1):52-56 - PubMed
  41. J Biol Chem. 2006 Mar 3;281(9):6058-69 - PubMed
  42. Biomaterials. 2010 Apr;31(10):2755-61 - PubMed
  43. J Biomed Mater Res A. 2006 Mar 1;76(3):551-60 - PubMed
  44. Annu Rev Neurosci. 2001;24:519-50 - PubMed
  45. J Am Chem Soc. 2003 Sep 24;125(38):11500-1 - PubMed
  46. Biomater Sci. 2018 Jul 24;6(8):2197-2208 - PubMed
  47. Adv Healthc Mater. 2015 Nov 18;4(16):2423-55 - PubMed
  48. J Biomed Mater Res A. 2017 Jul;105(7):1856-1866 - PubMed
  49. Matrix Biol. 2011 Jan;30(1):16-26 - PubMed
  50. Aust N Z J Ophthalmol. 1996 Aug;24(3):257-60 - PubMed
  51. J Biol Chem. 1997 Aug 29;272(35):21824-30 - PubMed
  52. Mol Diagn Ther. 2020 Jun;24(3):299-309 - PubMed
  53. Mol Inform. 2017 May;36(5-6): - PubMed
  54. Nat Biotechnol. 2007 Jan;25(1):132-8 - PubMed
  55. Biotechnol Appl Biochem. 2018 May;65(3):306-322 - PubMed
  56. Proc Natl Acad Sci U S A. 1987 Feb;84(3):764-8 - PubMed
  57. Tissue Eng Part A. 2017 Sep;23(17-18):946-957 - PubMed
  58. J Mol Biol. 1982 May 5;157(1):105-32 - PubMed
  59. Front Bioeng Biotechnol. 2019 May 07;7:95 - PubMed
  60. Colorectal Dis. 2018 Mar;20(3):243-251 - PubMed
  61. Biomaterials. 2010 Nov;31(32):8313-22 - PubMed
  62. Tissue Eng Part A. 2017 Dec;23(23-24):1423-1435 - PubMed
  63. Protein Expr Purif. 2008 Jun;59(2):274-81 - PubMed
  64. J Tissue Eng Regen Med. 2017 Mar;11(3):843-854 - PubMed
  65. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2824-9 - PubMed
  66. J Shoulder Elbow Surg. 2019 Mar;28(3):503-509 - PubMed
  67. J Am Acad Dermatol. 1989 Dec;21(6):1203-8 - PubMed
  68. J Biol Chem. 2005 Apr 8;280(14):13848-57 - PubMed
  69. Methods Mol Biol. 2018;1868:3-7 - PubMed
  70. J Biol Chem. 1987 Nov 15;262(32):15696-701 - PubMed
  71. J Assist Reprod Genet. 2020 Sep;37(9):2105-2117 - PubMed
  72. Protein J. 2017 Aug;36(4):322-331 - PubMed
  73. World J Microbiol Biotechnol. 2016 Jun;32(6):100 - PubMed
  74. J Biol Chem. 1994 Apr 15;269(15):11584-9 - PubMed
  75. Adv Mater. 2019 Jan;31(1):e1801651 - PubMed
  76. Am J Pathol. 2015 Jan;185(1):214-29 - PubMed
  77. Hum Mutat. 2008 Jun;29(6):841-51 - PubMed
  78. J Invest Dermatol. 1987 Apr;88(4):362-8 - PubMed
  79. Mar Drugs. 2018 Dec 08;16(12): - PubMed
  80. Cytokine. 2002 May 21;18(4):214-21 - PubMed
  81. Bull Am Coll Surg. 1997 Jul;82(7):13-5, 72 - PubMed
  82. Biomolecules. 2019 Sep 04;9(9): - PubMed
  83. Neurosurgery. 2018 Sep 1;83(3):377-384 - PubMed
  84. Appl Microbiol Biotechnol. 2005 Dec;69(3):245-52 - PubMed
  85. J Biomed Mater Res A. 2015 Apr;103(4):1357-65 - PubMed
  86. Bioengineered. 2014 Jul-Aug;5(4):227-33 - PubMed
  87. J Struct Biol. 2007 Feb;157(2):297-307 - PubMed
  88. J Biol Chem. 2014 Feb 21;289(8):4941-51 - PubMed
  89. Biophys J. 2016 Dec 6;111(11):2404-2416 - PubMed
  90. Adv Drug Deliv Rev. 2016 Feb 1;97:69-84 - PubMed
  91. Cold Spring Harb Perspect Biol. 2011 Jan 01;3(1):a004978 - PubMed
  92. Spine J. 2020 May;20(5):677-684 - PubMed
  93. Biochem Biophys Res Commun. 2006 May 12;343(3):692-9 - PubMed
  94. J Biomed Mater Res B Appl Biomater. 2019 Jul;107(5):1420-1430 - PubMed
  95. Materials (Basel). 2020 Sep 23;13(19): - PubMed
  96. Org Biomol Chem. 2019 Sep 21;17(35):8031-8047 - PubMed
  97. Int J Mol Sci. 2020 Jun 11;21(11): - PubMed
  98. Biomaterials. 2014 Mar;35(8):2420-7 - PubMed
  99. J Biol Chem. 1995 Jun 2;270(22):13105-11 - PubMed
  100. J Am Acad Dermatol. 2011 Jan;64(1):1-34; quiz 35-6 - PubMed
  101. Sci Rep. 2017 Jan 11;7:39805 - PubMed
  102. Tissue Eng. 1999 Feb;5(1):53-65 - PubMed
  103. Sci Transl Med. 2010 Aug 25;2(46):46ra61 - PubMed
  104. Appl Microbiol Biotechnol. 2014 May;98(10):4445-55 - PubMed
  105. Annu Rev Food Sci Technol. 2015;6:527-57 - PubMed
  106. J Cosmet Dermatol. 2018 Feb;17(1):20-26 - PubMed
  107. J Biomed Mater Res. 2001 Oct;57(1):48-58 - PubMed
  108. J Biomed Mater Res A. 2020 Jun 5;: - PubMed
  109. J Biol Chem. 1999 Aug 6;274(32):22464-8 - PubMed
  110. Proc Natl Acad Sci U S A. 1992 Oct 15;89(20):9860-4 - PubMed
  111. J Biomech. 2003 Oct;36(10):1529-53 - PubMed
  112. J Struct Biol. 2014 Jun;186(3):451-61 - PubMed
  113. Int J Biol Macromol. 2020 Apr 15;149:1275-1284 - PubMed
  114. J Biol Chem. 2005 Jan 7;280(1):191-8 - PubMed
  115. Biochem J. 1994 Feb 15;298 ( Pt 1):31-7 - PubMed
  116. Cytotechnology. 2020 Oct;72(5):715-730 - PubMed
  117. Bioengineered. 2014 Jan-Feb;5(1):49-52 - PubMed
  118. Mol Ther. 2009 Jan;17(1):26-33 - PubMed
  119. Subcell Biochem. 2017;82:601-629 - PubMed
  120. Tissue Eng Part A. 2013 Jul;19(13-14):1507-18 - PubMed
  121. Cell Transplant. 2019 Sep-Oct;28(9-10):1242-1256 - PubMed
  122. J Biol Chem. 1996 May 17;271(20):11988-95 - PubMed
  123. BMC Biotechnol. 2011 Jun 24;11:69 - PubMed
  124. Appl Microbiol Biotechnol. 2008 May;79(2):195-202 - PubMed
  125. Regen Biomater. 2020 Jun;7(3):293-302 - PubMed
  126. J Struct Biol. 2018 Jan;201(1):76-83 - PubMed
  127. Int J Biol Macromol. 2019 Oct 15;139:967-974 - PubMed
  128. Biochemistry. 2003 Oct 7;42(39):11434-42 - PubMed
  129. Protein Sci. 2003 Sep;12(9):2063-72 - PubMed
  130. Biomacromolecules. 2009 Sep 14;10(9):2640-5 - PubMed
  131. Nat Commun. 2019 Oct 25;10(1):4866 - PubMed
  132. J Orthop Surg Res. 2019 Jan 3;14(1):2 - PubMed
  133. J Biol Chem. 2008 Jul 25;283(30):21187-97 - PubMed
  134. Sci Rep. 2013 Oct 04;3:2864 - PubMed
  135. Allergy. 2000 Feb;55(2):108-15 - PubMed
  136. J Biol Chem. 1998 Nov 27;273(48):31822-8 - PubMed
  137. J Tissue Eng Regen Med. 2018 May;12(5):1186-1194 - PubMed
  138. Nat Rev Dis Primers. 2020 Sep 24;6(1):78 - PubMed
  139. EMBO J. 1992 Dec;11(12):4281-90 - PubMed
  140. Clin Mater. 1992;9(3-4):155-62 - PubMed
  141. Hepatology. 2020 Aug;72(2):729-741 - PubMed
  142. Protein Sci. 2009 Jun;18(6):1241-51 - PubMed
  143. J Biol Chem. 1998 Jun 19;273(25):15598-604 - PubMed
  144. J Invest Dermatol. 2015 Dec;135(12):3060-3067 - PubMed
  145. J Investig Allergol Clin Immunol. 2000 Mar-Apr;10(2):107-9 - PubMed
  146. Nat Biotechnol. 1999 Apr;17(4):385-9 - PubMed
  147. J Funct Biomater. 2019 Sep 02;10(3): - PubMed
  148. FEBS Lett. 2000 Mar 3;469(1):132-6 - PubMed
  149. Regen Ther. 2020 May 19;14:284-295 - PubMed
  150. J Mol Biol. 2004 Dec 3;344(4):993-1003 - PubMed
  151. J Struct Biol. 1998;122(1-2):111-8 - PubMed

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