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Robertson H, Dinkova-Kostova AT, Hayes JD. NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis. Cancers (Basel). 2020;12(12)doi: 10.3390/cancers12123609.
Robertson, H., Dinkova-Kostova, A. T., & Hayes, J. D. (2020). NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis. Cancers, 12(12), . https://doi.org/10.3390/cancers12123609
Robertson, Holly, et al. "NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis." Cancers vol. 12,12 (2020). doi: https://doi.org/10.3390/cancers12123609
Robertson H, Dinkova-Kostova AT, Hayes JD. NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis. Cancers (Basel). 2020 Dec 02;12(12). doi: 10.3390/cancers12123609. PMID: 33276631; PMCID: PMC7761610.
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Cancers (Basel). 2020 Dec 02;12(12). doi: 10.3390/cancers12123609.

NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis.

Cancers

Holly Robertson, Albena T Dinkova-Kostova, John D Hayes

Affiliations

  1. Jacqui Wood Cancer Centre, Division of Cellular Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK.
  2. Wellcome Trust Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.

PMID: 33276631 PMCID: PMC7761610 DOI: 10.3390/cancers12123609

Abstract

NF-E2 p45-related factor 2 (NRF2, encoded in the human by

Keywords: ATF4; Cullin 3; KEAP1; NADPH generation; NRF2; adaptation; antioxidant; autophagy; bioactivation; bladder; chemoprevention; chemotherapy; colon; drug metabolism; drug resistance; glutathione; head and neck; initiation; liver; lung; metastasis; oesophagus; oncogene; oxidative stress; pentose phosphate pathway; progression; proteasome; quinone-containing drugs; reactive oxygen species; rectum; recurrent disease; stomach; thioredoxin; tumour suppressor

References

  1. J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):853-863 - PubMed
  2. Biomarkers. 2012 Dec;17(8):671-91 - PubMed
  3. Elife. 2017 Oct 02;6: - PubMed
  4. Biochem J. 1991 Oct 15;279 ( Pt 2):385-98 - PubMed
  5. J Biol Chem. 1983 Feb 10;258(3):2052-62 - PubMed
  6. Ann Oncol. 2011 Jul;22(7):1653-1660 - PubMed
  7. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13943-8 - PubMed
  8. Nat Commun. 2018 Nov 23;9(1):4962 - PubMed
  9. J Natl Cancer Inst. 1972 May;48(5):1425-30 - PubMed
  10. Cancer Res. 2016 May 15;76(10):3088-96 - PubMed
  11. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13561-6 - PubMed
  12. Rep Biochem Mol Biol. 2020 Apr;9(1):33-39 - PubMed
  13. Biochemistry. 1992 Sep 1;31(34):7879-85 - PubMed
  14. Cancer Res. 1979 Aug;39(8):2971-7 - PubMed
  15. Trends Biochem Sci. 2014 Aug;39(8):347-54 - PubMed
  16. Antioxid Redox Signal. 2018 Dec 1;29(16):1535-1552 - PubMed
  17. Oncotarget. 2016 Aug 16;7(33):53502-53514 - PubMed
  18. J Natl Cancer Inst. 2019 Oct 1;111(10):1033-1041 - PubMed
  19. Mol Cell Biol. 2005 Sep;25(18):8044-51 - PubMed
  20. Mol Carcinog. 2013 Oct;52(10):824-34 - PubMed
  21. Dev Cell. 2018 Jul 16;46(2):145-161.e10 - PubMed
  22. J Pathol. 2010 Mar;220(4):446-51 - PubMed
  23. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3410-5 - PubMed
  24. Nat Med. 2017 Nov;23(11):1362-1368 - PubMed
  25. Mol Cell. 2013 Sep 12;51(5):618-31 - PubMed
  26. Cancer Res. 1994 Aug 15;54(16):4313-20 - PubMed
  27. J Biol Chem. 2010 Mar 12;285(11):8171-84 - PubMed
  28. Nat Rev Drug Discov. 2019 Apr;18(4):295-317 - PubMed
  29. Cancer Res. 2017 Sep 15;77(18):4797-4808 - PubMed
  30. Hepatology. 2016 Jan;63(1):173-84 - PubMed
  31. Exp Mol Med. 2018 Aug 7;50(8):96 - PubMed
  32. Arch Toxicol. 2011 Apr;85(4):273-84 - PubMed
  33. Mol Med. 2020 May 20;26(1):48 - PubMed
  34. Nature. 2015 Jan 29;517(7536):576-82 - PubMed
  35. Biochem J. 2002 Jul 15;365(Pt 2):405-16 - PubMed
  36. Cell Rep. 2019 Jul 16;28(3):746-758.e4 - PubMed
  37. Free Radic Biol Med. 2015 Nov;88(Pt B):108-146 - PubMed
  38. BMC Cell Biol. 2014 Jul 10;15:28 - PubMed
  39. Nat Metab. 2019 May;1(5):519-531 - PubMed
  40. Cancer Sci. 2020 Apr;111(4):1156-1164 - PubMed
  41. Mol Cell Proteomics. 2016 Apr;15(4):1220-31 - PubMed
  42. Invest Ophthalmol Vis Sci. 2011 Mar 02;52(3):1226-34 - PubMed
  43. Cancer Res. 1966 Jul;26(7):1520-6 - PubMed
  44. Autophagy. 2016 Oct 2;12(10):1902-1916 - PubMed
  45. Cancer Cell. 2018 Jul 9;34(1):21-43 - PubMed
  46. Oncogene. 2019 Dec;38(50):7473-7490 - PubMed
  47. Nat Commun. 2019 Sep 13;10(1):4190 - PubMed
  48. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3147-50 - PubMed
  49. Cancer. 2001 Sep 15;92(6):1525-30 - PubMed
  50. Genes Dev. 2016 Sep 1;30(17):1913-30 - PubMed
  51. Aging Dis. 2019 Jun 01;10(3):637-651 - PubMed
  52. Genome Biol. 2011;12(4):220 - PubMed
  53. Mol Cell Biol. 2004 Aug;24(16):7130-9 - PubMed
  54. Nat Commun. 2020 Nov 20;11(1):5911 - PubMed
  55. Mol Cancer. 2007 Nov 22;6:75 - PubMed
  56. Cell. 2018 Apr 5;173(2):371-385.e18 - PubMed
  57. BMC Cancer. 2018 Jan 6;18(1):46 - PubMed
  58. Mol Cell Biol. 2004 Dec;24(24):10941-53 - PubMed
  59. Drug Metab Rev. 1984-1985;15(7):1307-34 - PubMed
  60. N Engl J Med. 2017 Jun 1;376(22):2109-2121 - PubMed
  61. Free Radic Biol Med. 2015 Nov;88(Pt B):158-167 - PubMed
  62. Nat Genet. 2003 Nov;35(3):238-45 - PubMed
  63. Cancer Res. 1993 Sep 1;53(17):3887-94 - PubMed
  64. Cancer Res. 2019 Mar 1;79(5):889-898 - PubMed
  65. Antioxid Redox Signal. 2015 Sep 10;23(8):651-64 - PubMed
  66. Hepatology. 2014 Jan;59(1):228-41 - PubMed
  67. Food Cosmet Toxicol. 1973 Apr;11(2):209-17 - PubMed
  68. Carcinogenesis. 2008 Jun;29(6):1235-43 - PubMed
  69. Genes Dev. 2013 Oct 15;27(20):2179-91 - PubMed
  70. Mol Cell Biol. 2020 Oct 26;40(22): - PubMed
  71. Am J Physiol Gastrointest Liver Physiol. 2020 Mar 1;318(3):G419-G427 - PubMed
  72. Front Oncol. 2020 Aug 19;10:1575 - PubMed
  73. Biochem Biophys Res Commun. 1997 Jul 18;236(2):313-22 - PubMed
  74. Arch Biochem Biophys. 2008 Sep 1;477(1):139-45 - PubMed
  75. Oncol Lett. 2013 Sep;6(3):719-721 - PubMed
  76. Mol Pharmacol. 1995 Sep;48(3):499-504 - PubMed
  77. Nat Genet. 2020 Feb;52(2):208-218 - PubMed
  78. Free Radic Biol Med. 2017 Feb;103:236-247 - PubMed
  79. Head Neck. 2006 Sep;28(9):813-8 - PubMed
  80. Cancer Res. 1985 Jan;45(1):1-8 - PubMed
  81. J Biol Chem. 2004 Dec 24;279(52):54750-8 - PubMed
  82. J Biol Chem. 2010 Oct 29;285(44):33747-55 - PubMed
  83. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11908-13 - PubMed
  84. Pharmacol Rev. 1966 Mar;18(1):805-38 - PubMed
  85. Breast Cancer Res Treat. 2012 Feb;132(1):175-87 - PubMed
  86. Cancer Res. 2008 Mar 1;68(5):1303-9 - PubMed
  87. Nat Commun. 2016 Jul 12;7:12156 - PubMed
  88. Biochem Biophys Res Commun. 2006 Jan 6;339(1):79-88 - PubMed
  89. PLoS One. 2017 May 18;12(5):e0177549 - PubMed
  90. Cancer Res. 2000 Feb 15;60(4):957-69 - PubMed
  91. Cancer Cell. 2017 Nov 13;32(5):539-541 - PubMed
  92. Mol Cell Biol. 1995 Aug;15(8):4184-93 - PubMed
  93. Nat Genet. 2012 May 06;44(6):694-8 - PubMed
  94. Int J Mol Sci. 2020 Jul 29;21(15): - PubMed
  95. Cell. 2016 Oct 20;167(3):606-609 - PubMed
  96. Carcinogenesis. 2017 Jul 1;38(7):717-727 - PubMed
  97. Cancers (Basel). 2018 Dec 03;10(12): - PubMed
  98. Cell. 2017 Jun 15;169(7):1327-1341.e23 - PubMed
  99. Cancer Res. 1984 Dec;44(12 Pt 1):5463-74 - PubMed
  100. J Carcinog. 2012;11:8 - PubMed
  101. Cancer Chemother Pharmacol. 2019 Jun;83(6):1183-1189 - PubMed
  102. Cancer Res. 2002 Sep 15;62(18):5196-203 - PubMed
  103. Oncotarget. 2015 Jan 20;6(2):1315-26 - PubMed
  104. Carcinogenesis. 1986 Aug;7(8):1379-81 - PubMed
  105. Genes Dev. 2016 Aug 1;30(15):1704-17 - PubMed
  106. Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R18-36 - PubMed
  107. Cancer Res. 1978 Dec;38(12):4486-95 - PubMed
  108. J Hepatol. 2018 Sep;69(3):635-643 - PubMed
  109. Cell. 2013 Nov 7;155(4):948-62 - PubMed
  110. Cancer Prev Res (Phila). 2015 May;8(5):444-54 - PubMed
  111. PLoS Med. 2006 Oct;3(10):e420 - PubMed
  112. Oncogene. 2020 Oct;39(44):6841-6855 - PubMed
  113. Nat Genet. 2016 Jun;48(6):607-16 - PubMed
  114. Proc Natl Acad Sci U S A. 1976 Nov;73(11):3867-71 - PubMed
  115. Nat Biotechnol. 2020 Jul;38(7):824-844 - PubMed
  116. Acc Chem Res. 2015 Oct 20;48(10):2715-23 - PubMed
  117. Clin Cancer Res. 1998 Sep;4(9):2065-70 - PubMed
  118. Toxicol Sci. 2016 Jul;152(1):40-52 - PubMed
  119. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1433-8 - PubMed
  120. Nature. 2011 Jul 06;475(7354):106-9 - PubMed
  121. Nat Chem Biol. 2015 Jan;11(1):64-70 - PubMed
  122. Cancer Res. 1978 Dec;38(12):4496-8 - PubMed
  123. Mol Cancer Ther. 2007 Jan;6(1):154-62 - PubMed
  124. Free Radic Biol Med. 2018 Feb 1;115:361-370 - PubMed
  125. Oxid Med Cell Longev. 2013;2013:305861 - PubMed
  126. Cancer Res. 1958 May;18(4):469-77 - PubMed
  127. Cancer Res. 1986 Aug;46(8):3924-31 - PubMed
  128. Chem Res Toxicol. 2014 Nov 17;27(11):1901-17 - PubMed
  129. Cancer Res. 2004 Sep 15;64(18):6424-31 - PubMed
  130. Cell Biosci. 2019 Jun 26;9:53 - PubMed
  131. Biochem Soc Trans. 2016 Jun 15;44(3):925-31 - PubMed
  132. Cancer Res. 1987 Aug 15;47(16):4271-7 - PubMed
  133. Nature. 2014 Sep 11;513(7517):202-9 - PubMed
  134. Cancer Prev Res (Phila). 2013 Feb;6(2):149-59 - PubMed
  135. Cancer Cell. 2015 Feb 9;27(2):211-22 - PubMed
  136. Oncogene. 2017 Sep 14;36(37):5285-5295 - PubMed
  137. Free Radic Biol Med. 2017 Mar;104:75-103 - PubMed
  138. Oncol Lett. 2016 Dec;12(6):4333-4338 - PubMed
  139. EMBO J. 2004 Apr 21;23(8):1681-7 - PubMed
  140. Clin Cancer Res. 2018 Jan 15;24(2):334-340 - PubMed
  141. Nucleic Acids Res. 2010 Sep;38(17):5718-34 - PubMed
  142. BMC Cancer. 2015 Jan 15;15:5 - PubMed
  143. Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9926-30 - PubMed
  144. Cancer Genet. 2020 Oct;248-249:1-10 - PubMed
  145. Proc Natl Acad Sci U S A. 1980 Sep;77(9):5216-20 - PubMed
  146. Genes Dev. 2011 Apr 15;25(8):795-800 - PubMed
  147. Cell Cycle. 2020 Oct;19(19):2411-2425 - PubMed
  148. J Cancer Res Clin Oncol. 2014 Oct;140(10):1723-31 - PubMed
  149. Dev Cell. 2019 Sep 23;50(6):690-703.e6 - PubMed
  150. Mol Cell Biol. 2006 Apr;26(8):2887-900 - PubMed
  151. Cancer Cell. 2011 Oct 18;20(4):524-37 - PubMed
  152. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14547-51 - PubMed
  153. Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10350-4 - PubMed
  154. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8773-8 - PubMed
  155. PLoS Biol. 2020 Feb 13;18(2):e3000620 - PubMed
  156. Cancer Res. 2020 Aug 15;80(16):3331-3344 - PubMed
  157. J Hepatol. 2014 Nov;61(5):1088-96 - PubMed
  158. Cell Physiol Biochem. 2018;49(5):1717-1733 - PubMed
  159. Biochem Pharmacol. 1988 Dec 15;37(24):4661-9 - PubMed
  160. EMBO J. 2019 Aug 1;38(15):e101964 - PubMed
  161. Biochem J. 1993 May 15;292 ( Pt 1):13-8 - PubMed
  162. Mol Pharmacol. 2006 Oct;70(4):1194-203 - PubMed
  163. Cancer Cell. 2020 Aug 10;38(2):247-262.e11 - PubMed
  164. J Natl Cancer Inst. 1974 May;52(5):1583-7 - PubMed
  165. Neoplasia. 2011 Sep;13(9):864-73 - PubMed
  166. Biosci Rep. 2015 Sep 04;35(5): - PubMed
  167. Nat Genet. 2015 Dec;47(12):1475-81 - PubMed
  168. J Invest Dermatol. 2014 Jul;134(7):1998-2004 - PubMed
  169. Int J Clin Exp Pathol. 2014 Feb 15;7(3):1124-31 - PubMed
  170. EMBO Mol Med. 2014 Apr;6(4):442-57 - PubMed
  171. Oncogenesis. 2017 Aug 14;6(8):e371 - PubMed
  172. Free Radic Res. 2019 Jul 24;:1-9 - PubMed
  173. Antioxid Redox Signal. 2013 Aug 10;19(5):465-81 - PubMed
  174. Cancer Res. 2001 Apr 15;61(8):3299-307 - PubMed
  175. Nature. 2015 Nov 12;527(7577):186-91 - PubMed
  176. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2040-5 - PubMed
  177. Nat Prod Rep. 2020 Jun 1;37(6):797-826 - PubMed
  178. Clin Cancer Res. 2015 Oct 15;21(20):4514-24 - PubMed
  179. ACS Chem Biol. 2016 Nov 18;11(11):3214-3225 - PubMed
  180. Autophagy. 2013 Aug;9(8):1131-58 - PubMed
  181. Sci Rep. 2019 Sep 25;9(1):13896 - PubMed
  182. Nature. 2014 Mar 20;507(7492):315-22 - PubMed
  183. Ann Oncol. 2015 Jun;26(6):1216-1223 - PubMed
  184. Cancer Res. 1994 Jun 15;54(12):3196-201 - PubMed
  185. Mol Cell Biol. 2006 Jan;26(1):221-9 - PubMed
  186. Nucleic Acids Res. 2012 Aug;40(15):7416-29 - PubMed
  187. J Biol Chem. 1997 Jan 17;272(3):1437-9 - PubMed
  188. Cancer Discov. 2012 May;2(5):401-4 - PubMed
  189. Adv Enzyme Regul. 1993;33:281-96 - PubMed
  190. Toxicol Appl Pharmacol. 2009 Jun 15;237(3):267-80 - PubMed
  191. Cell Death Dis. 2019 Oct 28;10(11):821 - PubMed
  192. Mol Cell Biol. 2020 Nov 2;: - PubMed
  193. Cancer Res. 2014 Feb 1;74(3):808-17 - PubMed
  194. Free Radic Biol Med. 2012 Oct 1;53(7):1522-30 - PubMed
  195. Cancer Cell. 2020 Aug 10;38(2):167-197 - PubMed
  196. Cancer Res. 2015 Nov 15;75(22):4817-29 - PubMed
  197. Proc Natl Acad Sci U S A. 1976 Oct;73(10):3381-5 - PubMed
  198. Oxid Med Cell Longev. 2013;2013:763257 - PubMed
  199. BMC Cancer. 2012 Feb 13;12:66 - PubMed
  200. J Pathol. 2020 Oct;252(2):125-137 - PubMed
  201. J Natl Cancer Inst. 1982 Mar;68(3):493-6 - PubMed
  202. Cancer Lett. 2018 Dec 1;438:154-164 - PubMed
  203. Thorac Cancer. 2020 Mar;11(3):738-747 - PubMed
  204. Br J Nurs. 2013 Sep 12-25;22(17):S15-6, S18, S20-2 - PubMed
  205. Cancer Res. 2006 Aug 15;66(16):8293-6 - PubMed
  206. Mol Cell Biol. 1994 Nov;14(11):7581-91 - PubMed
  207. Cancer Res. 1968 May;28(5):934-7 - PubMed
  208. Cancer Res. 1952 May;12(5):356-61 - PubMed
  209. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18838-43 - PubMed
  210. Mol Cell Biol. 2005 Jan;25(1):162-71 - PubMed
  211. Food Cosmet Toxicol. 1973 Apr;11(2):199-207 - PubMed
  212. Proc Natl Acad Sci U S A. 2002 May 28;99(11):7610-5 - PubMed
  213. J Biol Chem. 2003 Jun 13;278(24):21592-600 - PubMed
  214. J Hepatol. 2020 Jun;72(6):1182-1195 - PubMed
  215. Nature. 2018 Oct;562(7728):600-604 - PubMed
  216. Pharmacol Rep. 2016 Apr;68(2):310-8 - PubMed
  217. Cancers (Basel). 2020 Jul 31;12(8): - PubMed
  218. Free Radic Biol Med. 2000 Aug;29(3-4):246-53 - PubMed
  219. Mol Carcinog. 2018 Feb;57(2):182-192 - PubMed
  220. Nat Genet. 2014 May;46(5):467-73 - PubMed
  221. J Biol Chem. 1988 Sep 15;263(26):13324-32 - PubMed
  222. Eur Urol. 2017 Sep;72(3):354-365 - PubMed
  223. Cell Metab. 2018 Apr 3;27(4):935-943.e4 - PubMed
  224. Proc Natl Acad Sci U S A. 1988 Nov;85(21):8261-5 - PubMed
  225. Cancer Res. 1982 Apr;42(4):1205-7 - PubMed
  226. Cancer Res. 1990 Dec 1;50(23):7483-9 - PubMed
  227. Anticancer Agents Med Chem. 2018;18(3):388-393 - PubMed
  228. Cancer Res. 2005 Nov 1;65(21):10006-15 - PubMed
  229. Cancer Res. 2012 Jun 15;72(12):3038-47 - PubMed
  230. Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13568-73 - PubMed
  231. Genes Dev. 1999 Jan 1;13(1):76-86 - PubMed
  232. Adv Exp Med Biol. 2014;799:85-117 - PubMed
  233. J Pathol. 2018 Mar;244(3):346-357 - PubMed
  234. Trends Biochem Sci. 2014 Apr;39(4):199-218 - PubMed
  235. Photochem Photobiol Sci. 2010 Apr;9(4):597-600 - PubMed
  236. Carcinogenesis. 1984 Jun;5(6):841-4 - PubMed
  237. Nature. 2018 Oct;562(7726):217-222 - PubMed
  238. J Biol Chem. 1991 Jun 25;266(18):11632-9 - PubMed
  239. Mol Cancer Res. 2020 Dec;18(12):1777-1788 - PubMed
  240. Nature. 2014 May 1;509(7498):91-5 - PubMed
  241. Chem Biol Interact. 1998 Apr 24;111-112:51-67 - PubMed
  242. Biochemistry. 1997 Mar 18;36(11):3056-60 - PubMed
  243. Biochem Pharmacol. 1988 Dec 15;37(24):4671-7 - PubMed
  244. Cell Commun Signal. 2020 Jun 23;18(1):98 - PubMed
  245. Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2965-9 - PubMed
  246. Sci Signal. 2020 Aug 18;13(645): - PubMed
  247. Biomed Rep. 2018 Nov;9(5):375-382 - PubMed
  248. Mol Cell Biol. 2014 Mar;34(5):832-46 - PubMed
  249. Annu Rev Pharmacol Toxicol. 2007;47:263-92 - PubMed
  250. BMC Cancer. 2010 Oct 08;10:540 - PubMed
  251. Cancer Cell. 2018 Jun 11;33(6):985-1003.e7 - PubMed
  252. J Biol Chem. 2000 Feb 25;275(8):5416-24 - PubMed
  253. J Biol Chem. 2006 Aug 25;281(34):24756-68 - PubMed
  254. Cancer Cell. 2012 Jul 10;22(1):66-79 - PubMed
  255. Cell Rep. 2016 Sep 6;16(10):2605-2617 - PubMed
  256. Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15259-64 - PubMed
  257. Biochem Pharmacol. 2014 Nov 1;92(1):90-101 - PubMed
  258. Toxicol Sci. 2011 Oct;123(2):590-600 - PubMed
  259. Biochem J. 1992 Jul 1;285 ( Pt 1):173-80 - PubMed
  260. Cancer Cell. 2011 Oct 18;20(4):511-23 - PubMed
  261. Redox Biol. 2020 Feb;30:101425 - PubMed
  262. Biochem J. 1991 Feb 1;273 ( Pt 3):711-7 - PubMed
  263. Mol Cell Biol. 2010 Jun;30(12):3016-26 - PubMed
  264. Sci Signal. 2013 Apr 02;6(269):pl1 - PubMed
  265. Science. 2020 Apr 3;368(6486):85-89 - PubMed
  266. J Biol Chem. 2003 Mar 7;278(10):8135-45 - PubMed
  267. Hepatology. 2015 Sep;62(3):851-62 - PubMed
  268. Cancer Res. 1978 May;38(5):1410-3 - PubMed
  269. Proc Natl Acad Sci U S A. 1985 Dec;82(23):8232-6 - PubMed
  270. Mol Cells. 2009 Mar 31;27(3):279-82 - PubMed
  271. Mol Cell Biol. 2007 Nov;27(21):7511-21 - PubMed
  272. Cell Metab. 2020 Feb 4;31(2):339-350.e4 - PubMed
  273. Nat Chem Biol. 2018 Feb;14(2):148-155 - PubMed
  274. Biochem Soc Trans. 2000 Feb;28(2):33-41 - PubMed
  275. Chem Res Toxicol. 2001 Jun;14(6):727-37 - PubMed
  276. Mol Cell Biol. 2004 Oct;24(19):8477-86 - PubMed
  277. Cancer Res. 1953 Nov;13(11):802-6 - PubMed
  278. J Thorac Oncol. 2019 Nov;14(11):1881-1883 - PubMed
  279. CA Cancer J Clin. 2018 Nov;68(6):394-424 - PubMed
  280. Cancer Res. 1970 Jul;30(7):1922-5 - PubMed
  281. Food Chem Toxicol. 1999 Sep-Oct;37(9-10):1027-38 - PubMed
  282. World J Gastroenterol. 2016 Feb 21;22(7):2284-93 - PubMed
  283. Cancer Cell. 2018 Jan 8;33(1):125-136.e3 - PubMed
  284. Cancer Lett. 2006 May 8;236(1):72-9 - PubMed
  285. J Biol Chem. 2000 May 26;275(21):16023-9 - PubMed
  286. Cell Death Dis. 2014 Apr 17;5:e1183 - PubMed
  287. Cancers (Basel). 2020 Aug 16;12(8): - PubMed
  288. Mol Pharmacol. 2014 Jun;85(6):849-57 - PubMed
  289. Cell. 2018 Apr 5;173(2):321-337.e10 - PubMed
  290. Cancer Res. 1982 Jul;42(7):2609-15 - PubMed
  291. Crit Rev Biochem Mol Biol. 1995;30(6):445-600 - PubMed
  292. Mol Cancer Res. 2017 Nov;15(11):1570-1578 - PubMed
  293. Cancer Lett. 2006 Aug 28;240(2):243-52 - PubMed
  294. Free Radic Biol Med. 2011 Jun 1;50(11):1599-609 - PubMed
  295. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19589-94 - PubMed
  296. J Biol Chem. 2016 May 6;291(19):10399-410 - PubMed
  297. Adv Cancer Res. 1979;29:175-274 - PubMed
  298. Free Radic Biol Med. 2012 Aug 15;53(4):807-16 - PubMed
  299. Trends Biochem Sci. 2009 Apr;34(4):176-88 - PubMed
  300. Cancer Res. 1969 Jan;29(1):236-50 - PubMed
  301. Nat Metab. 2020 Apr;2(4):318-334 - PubMed
  302. World J Urol. 2020 Aug;38(8):1895-1904 - PubMed
  303. Cancer Res. 2013 Jul 1;73(13):4158-68 - PubMed
  304. Head Neck. 2015 May;37(5):727-34 - PubMed
  305. Nat Chem. 2013 Apr;5(4):307-14 - PubMed
  306. Cancer Res. 2000 Aug 1;60(15):4179-86 - PubMed
  307. Proc Natl Acad Sci U S A. 1992 Jan 15;89(2):668-72 - PubMed
  308. Biomolecules. 2020 Sep 25;10(10): - PubMed
  309. Thorac Cancer. 2018 Jun;9(6):726-735 - PubMed
  310. Sci Transl Med. 2011 Apr 13;3(78):78ra32 - PubMed

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