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Logroscino G, Beghi E. Stroke epidemiology and COVID-19 pandemic. Curr Opin Neurol. 2021;34(1):3-10doi: 10.1097/WCO.0000000000000879.
Logroscino, G., & Beghi, E. (2021). Stroke epidemiology and COVID-19 pandemic. Current opinion in neurology, 34(1), 3-10. https://doi.org/10.1097/WCO.0000000000000879
Logroscino, Giancarlo, and Beghi, Ettore. "Stroke epidemiology and COVID-19 pandemic." Current opinion in neurology vol. 34,1 (2021): 3-10. doi: https://doi.org/10.1097/WCO.0000000000000879
Logroscino G, Beghi E. Stroke epidemiology and COVID-19 pandemic. Curr Opin Neurol. 2021 Feb 01;34(1):3-10. doi: 10.1097/WCO.0000000000000879. PMID: 33278139.
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Curr Opin Neurol. 2021 Feb 01;34(1):3-10. doi: 10.1097/WCO.0000000000000879.

Stroke epidemiology and COVID-19 pandemic.

Current opinion in neurology

Giancarlo Logroscino, Ettore Beghi

Affiliations

  1. Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology of the University of Bari at 'Pia Fondazione Card G. Panico" Hospital Tricase (Le).
  2. Department of Basic Medicine, Neuroscience and Sense Organs, University Aldo Moro, Bari.
  3. Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.

PMID: 33278139 DOI: 10.1097/WCO.0000000000000879

Abstract

PURPOSE OF REVIEW: The aim of this study was to describe the impact of the COVID-19 outbreak on the epidemiology, cause and clinical characteristics of incident stroke in different settings and populations.

RECENT FINDINGS: Several studies have shown that there are three main themes in the epidemiology of stroke during the COVID-19 pandemic: COVID-19 seems to be associated with stroke in a significant number of patients. This association has been reported in several clinical series, mainly from China. There is a consistent trend towards a decreased number of hospital admissions of stroke patients during the pandemic. There are no population-based data available on incident stroke in individuals with COVID-19.

SUMMARY: In this review, we report on increased rates and severe prognosis of ischemic stroke among individuals with COVID-19, probably explained by hypercoagulability and inflammation, documented since the early phase of disease.We confirm the presence of falling rates of new ischemic stroke admissions in hospitals, probably due to social consequences of the pandemic: fear to be infected or not adequately treated in the hospital. This phenomenon is restricted to mild stroke and transient ischemic attacks.Short and long-term consequences of this trend of new strokes in the pandemic need to be evaluated.

Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.

References

  1. Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet (London, England) 2020; 395:507–513. - PubMed
  2. Romero-Sánchez CM, Díaz-Maroto I, Fernández-Díaz E, et al. Neurologic manifestations in hospitalized patients with COVID-19: the ALBACOVID registry. Neurology 2020; 95:e1060–e1070. - PubMed
  3. Zhou Y, Li W, Wang D, et al. Clinical time course of COVID-19, its neurological manifestation and some thoughts on its management. Stroke Vasc Neurol 2020; 5:177–179. - PubMed
  4. Baig AM, Sanders EC. Potential neuroinvasive pathways of SARS-CoV-2: Deciphering the spectrum of neurological deficit seen in coronavirus disease-2019 (COVID-19). J Med Virol 2020; doi: 10.1002/jmv.26105. [Epub ahead of print]. PMID: 32492193; PMCID: PMC7300748. - PubMed
  5. Oxley TJ, Mocco J, Majidi S, et al. Large-vessel stroke as a presenting feature of Covid-19 in the young. N Engl J Med 2020; 382:e60. - PubMed
  6. Mao L, Jin H, Wang M, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol 2020; 77:683–690. - PubMed
  7. Qin C, Zhou L, Hu Z, et al. Clinical characteristics and outcomes of COVID-19 patients with a history of stroke in Wuhan, China. Stroke 2020; 51:2219–2223. - PubMed
  8. Helms J, Kremer S, Merdji H, et al. Neurologic features in severe SARS-CoV-2 infection. N Engl J Med 2020; 382:2268–2270. - PubMed
  9. Yaghi S, Ishida K, Torres J, et al. SARS-CoV-2 and stroke in a New York Healthcare System. Stroke 2020; 51:2002–2011. - PubMed
  10. Badawi A, Ryoo SG. Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis. Int J Infect Dis 2016; 49:129–133. - PubMed
  11. Merkler AE, Parikh NS, Mir S, et al. Risk of ischemic stroke in patients with coronavirus disease 2019 (COVID-19) vs patients with influenza. JAMA Neurol 2020; 77:1–7. doi: 10.1001/jamaneurol.2020.2730. [Epub ahead of print]. - PubMed
  12. Klok FA, Kruip M, van der Meer NJM, et al. Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: an updated analysis. Thromb Res 2020; 191:148–150. - PubMed
  13. Lodigiani C, Iapichino G, Carenzo L, et al. Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy. Thromb Res 2020; 191:9–14. - PubMed
  14. Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 2020; 323:1061–1069. - PubMed
  15. Corrales-Medina VF, Alvarez KN, Weissfeld LA, et al. Association between hospitalization for pneumonia and subsequent risk of cardiovascular disease. JAMA 2015; 313:264–274. - PubMed
  16. Siegler JE, Heslin ME, Thau L, et al. Falling stroke rates during COVID-19 pandemic at a Comprehensive Stroke Center: cover title: falling stroke rates during COVID-19. J Stroke Cerebrovasc Dis 2020; 29:104953. - PubMed
  17. Diegoli H, Magalhães PSC, Martins SCO, et al. Decrease in hospital admissions for transient ischemic attack, mild, and moderate stroke during the COVID-19 era. Stroke 2020; 51:2315–2321. - PubMed
  18. Zhao J, Rudd A, Liu R. Challenges and potential solutions of stroke care during the coronavirus disease 2019 (COVID-19) outbreak. Stroke 2020; 51:1356–1357. - PubMed
  19. Metzler B, Siostrzonek P, Binder RK, et al. Decline of acute coronary syndrome admissions in Austria since the outbreak of COVID-19: the pandemic response causes cardiac collateral damage. Eur Heart J 2020; 41:1852–1853. - PubMed
  20. Roffi M, Guagliumi G, Ibanez B. The obstacle course of reperfusion for ST-segment-elevation myocardial infarction in the COVID-19 pandemic. Circulation 2020; 141:1951–1953. - PubMed
  21. Lee SY, Khang YH, Lim HK. Impact of the 2015 Middle East Respiratory Syndrome outbreak on emergency care utilization and mortality in South Korea. Yonsei Med J 2019; 60:796–803. - PubMed
  22. Lipsitch M, Swerdlow DL, Finelli L. Defining the epidemiology of Covid-19: studies needed. N Engl J Med 2020; 382:1194–1196. - PubMed
  23. Logroscino G, Kurth T, Piccininni M. The reconstructed cohort design: a method to study rare neurodegenerative diseases in population-based settings. Neuroepidemiology 2020; 54:114–122. - PubMed
  24. Jeong HY, Jung KH, Mo H, et al. Characteristics and management of stroke in Korea: 2014–2018 data from Korean Stroke Registry. Int J Stroke 2020; 15:619–626. - PubMed
  25. Giles MF, Rothwell PM. Risk of stroke early after transient ischaemic attack: a systematic review and meta-analysis. Lancet Neurol 2007; 6:1063–1072. - PubMed
  26. Rothwell PM, Giles MF, Chandratheva A, et al. Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison. Lancet (London, England) 2007; 370:1432–1442. - PubMed
  27. Zylke JW, Bauchner H. Mortality and morbidity: the measure of a pandemic. JAMA 2020; 324:458–459. - PubMed
  28. Woolf SH, Chapman DA, Sabo RT, et al. Excess deaths from COVID-19 and other causes, March-April 2020. JAMA 2020; 324:510–513. - PubMed
  29. Baum A, Schwartz MD. Admissions to Veterans Affairs Hospitals for emergency conditions during the COVID-19 pandemic. JAMA 2020; 324:96–99. - PubMed
  30. Markus HS, Brainin M. COVID-19 and stroke: a global World Stroke Organization perspective. Int J Stroke 2020; 15:361–364. - PubMed
  31. Bres Bullrich M, Fridman S, Mandzia JL, et al. COVID-19: stroke admissions, emergency department visits, and prevention clinic referrals. Can J Neurol Sci 2020; 47:693–696. - PubMed
  32. Sacco RL, Boden-Albala B, Abel G, et al. Race-ethnic disparities in the impact of stroke risk factors: the northern Manhattan stroke study. Stroke 2001; 32:1725–1731. - PubMed
  33. Gardener H, Sacco RL, Rundek T, et al. Race and ethnic disparities in stroke incidence in the Northern Manhattan Study. Stroke 2020; 51:1064–1069. - PubMed
  34. Jones J, Sullivan PS, Sanchez T, et al. Similarities and differences in COVID-19 awareness, concern, and symptoms by race and ethnicity in the United States: a cross-sectional survey. J Med Internet Res 2020. - PubMed
  35. Alsan M, Stantcheva S, Yang D, Cutler D. Disparities in Coronavirus 2019 reported incidence, knowledge, and behavior among US adults. JAMA Netw Open 2020; 3:e2012403. - PubMed
  36. Leira EC, Russman AN, Biller J, et al. Preserving stroke care during the COVID-19 pandemic: potential issues and solutions. Neurology 2020; 95:124–133. - PubMed
  37. Temporary emergency guidance to US Stroke Centers during the Coronavirus Disease 2019 (COVID-19) pandemic: on behalf of the American Heart Association/American Stroke Association Stroke Council Leadership. Stroke 2020; 51:1910--1912. - PubMed
  38. Demaerschalk BM, Raman R, Ernstrom K, Meyer BC. Efficacy of telemedicine for stroke: pooled analysis of the Stroke Team Remote Evaluation Using a Digital Observation Camera (STRokE DOC) and STRokE DOC Arizona telestroke trials. Telemed J E Health 2012; 18:230–237. - PubMed
  39. Meyer BC, Raman R, Hemmen T, et al. Efficacy of site-independent telemedicine in the STRokE DOC trial: a randomised, blinded, prospective study. Lancet Neurol 2008; 7:787–795. - PubMed
  40. Wu TC, Parker SA, Jagolino A, et al. Telemedicine can replace the neurologist on a mobile stroke unit. Stroke 2017; 48:493–496. - PubMed
  41. Mohr NM, Young T, Harland KK, et al. Telemedicine is associated with faster diagnostic imaging in stroke patients: a cohort study. Telemed J E Health 2019; 25:93–100. - PubMed

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