Display options
Cite
Tan OL, Safii SH, Razali M. Clinical Efficacy of Single Application Local Drug Delivery and Adjunctive Agents in Nonsurgical Periodontal Therapy: A Systematic Review and Network Meta-Analysis. Pharmaceutics. 2020;12(11)doi: 10.3390/pharmaceutics12111086.
Tan, O. L., Safii, S. H., & Razali, M. (2020). Clinical Efficacy of Single Application Local Drug Delivery and Adjunctive Agents in Nonsurgical Periodontal Therapy: A Systematic Review and Network Meta-Analysis. Pharmaceutics, 12(11), . https://doi.org/10.3390/pharmaceutics12111086
Tan, Oi Leng, et al. "Clinical Efficacy of Single Application Local Drug Delivery and Adjunctive Agents in Nonsurgical Periodontal Therapy: A Systematic Review and Network Meta-Analysis." Pharmaceutics vol. 12,11 (2020). doi: https://doi.org/10.3390/pharmaceutics12111086
Tan OL, Safii SH, Razali M. Clinical Efficacy of Single Application Local Drug Delivery and Adjunctive Agents in Nonsurgical Periodontal Therapy: A Systematic Review and Network Meta-Analysis. Pharmaceutics. 2020 Nov 12;12(11). doi: 10.3390/pharmaceutics12111086. PMID: 33198248; PMCID: PMC7698182.
Copy Download .nbib Format: NLM
Share it on

Pharmaceutics. 2020 Nov 12;12(11). doi: 10.3390/pharmaceutics12111086.

Clinical Efficacy of Single Application Local Drug Delivery and Adjunctive Agents in Nonsurgical Periodontal Therapy: A Systematic Review and Network Meta-Analysis.

Pharmaceutics

Oi Leng Tan, Syarida Hasnur Safii, Masfueh Razali

Affiliations

  1. Centre for Restorative Dentistry, Unit of Periodontology, Faculty of Dentistry, National University of Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia.
  2. Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Kuala Lumpur 50603, Malaysia.

PMID: 33198248 PMCID: PMC7698182 DOI: 10.3390/pharmaceutics12111086

Abstract

This review aimed to rank the clinical efficacy of commercially available single-application local drug delivery and adjunctive agents (LDAs) compared with subgingival mechanical debridement (SMD) in nonsurgical periodontal therapy (NSPT). Randomized controlled clinical trials that compared LDAs against SMD alone or with placebo in adults (aged at least 18 years) diagnosed with periodontitis with a minimum of 6 months follow-up were included. A frequentist approach to random-effects network meta-analysis was implemented. The efficacies of the LDAs measured by probing pocket depth (PPD) reduction and clinical attachment level (CAL) gain were reported as mean difference (MD) with 95% confidence intervals (CIs). The treatments were ranked according to their P-score. Four network meta-analyses suggested that sulfonic/sulfuric acid gel (PPD MD -1.13 mm, 95% CI -1.74 to -0.53, P-score 0.91; CAL MD -1.09 mm, 95% CI -1.58 to -0.61, P-score 0.95) and doxycycline hyclate gel (PPD MD -0.90 mm, 95% CI -1.50 to -0.30, P-score 0.93; CAL MD -0.84 mm, 95% CI -1.40 to -0.28, P-score 0.92) were the most effective in reducing PPD and gaining CAL in split-mouth and parallel studies, respectively (moderate certainty of evidence). LDAs have differing efficacies, but they present with possible clinical significance over SMD alone in NSPT.

Keywords: anti-bacterial agents; anti-infective agents; evidence-based dentistry; local; meta-analysis; periodontal debridement; periodontal pocket; periodontitis; photochemotherapy

References

  1. Stat Med. 2014 Nov 10;33(25):4353-69 - PubMed
  2. Molecules. 2017 Dec 05;22(12): - PubMed
  3. Clin Oral Investig. 2018 Mar;22(2):791-800 - PubMed
  4. BMJ. 2019 Aug 28;366:l4898 - PubMed
  5. J Periodontal Res. 2017 Aug;52(4):651-665 - PubMed
  6. Head Face Med. 2012 Apr 05;8:12 - PubMed
  7. J Clin Periodontol. 2018 Jun;45 Suppl 20:S162-S170 - PubMed
  8. Biochem Med (Zagreb). 2012;22(3):276-82 - PubMed
  9. Ann Periodontol. 2003 Dec;8(1):79-98 - PubMed
  10. J Periodontol. 2016 Jun;87(6):613-6 - PubMed
  11. J Clin Periodontol. 2013 Aug;40(8):781-8 - PubMed
  12. ISME J. 2017 Sep;11(9):2075-2089 - PubMed
  13. Periodontol 2000. 2020 Oct;84(1):14-34 - PubMed
  14. Lasers Med Sci. 2015 Jan;30(1):27-34 - PubMed
  15. Photodiagnosis Photodyn Ther. 2016 Jun;14:84-90 - PubMed
  16. Oral Dis. 2009 Mar;15(2):155-61 - PubMed
  17. Aust Crit Care. 2010 May;23(2):93-7 - PubMed
  18. Res Synth Methods. 2018 Sep;9(3):431-440 - PubMed
  19. J Periodontal Res. 2020 Dec;55(6):946-958 - PubMed
  20. J Gen Intern Med. 2002 Jun;17(6):469-76 - PubMed
  21. Health Qual Life Outcomes. 2010 Nov 05;8:126 - PubMed
  22. J Periodontol. 2005 Aug;76(8):1227-36 - PubMed
  23. J Periodontal Res. 2018 Jun;53(3):288-297 - PubMed
  24. Antibiotics (Basel). 2019 Dec 30;9(1): - PubMed
  25. Diabetes Res Clin Pract. 2019 Nov;157:107843 - PubMed
  26. J Evid Based Dent Pract. 2020 Mar;20(1):101397 - PubMed
  27. Int J Dent. 2016;2016:1891074 - PubMed
  28. J Periodontol. 1998 May;69(5):507-20 - PubMed
  29. J Periodontol. 2002 Jun;73(6):608-15 - PubMed
  30. Ann Intern Med. 2015 Jun 2;162(11):777-84 - PubMed
  31. J Oral Maxillofac Res. 2011 Apr 01;2(1):e3 - PubMed
  32. Res Synth Methods. 2012 Jun;3(2):80-97 - PubMed
  33. Hua Xi Kou Qiang Yi Xue Za Zhi. 2006 Feb;24(1):32-5 - PubMed
  34. Periodontol 2000. 2019 Feb;79(1):15-21 - PubMed
  35. Photodiagnosis Photodyn Ther. 2019 Jun;26:29-35 - PubMed
  36. Periodontol 2000. 2005;39:132-44 - PubMed
  37. J Am Dent Assoc. 2003 May;134(5):583-91 - PubMed
  38. Int J Periodontics Restorative Dent. 2019 Nov/Dec;39(6):837-843 - PubMed
  39. J Clin Periodontol. 2013 Mar;40(3):227-41 - PubMed
  40. Int J Dent Hyg. 2006 Aug;4(3):114-21 - PubMed
  41. J Indian Soc Periodontol. 2012 Apr;16(2):179-83 - PubMed
  42. Periodontol 2000. 2003;31:43-54 - PubMed
  43. J Am Dent Assoc. 2015 Jul;146(7):525-35 - PubMed
  44. J Clin Epidemiol. 2019 Nov;115:1-13 - PubMed
  45. BMJ. 2014 Sep 24;349:g5630 - PubMed
  46. Lasers Med Sci. 2009 Sep;24(5):681-8 - PubMed
  47. Clin Oral Investig. 2013 Jan;17(1):55-66 - PubMed
  48. Indian J Dent Res. 2016 Mar-Apr;27(2):121-6 - PubMed
  49. J Evid Based Dent Pract. 2012 Sep;12(3 Suppl):50-60 - PubMed
  50. J Clin Periodontol. 2017 Jun;44(6):603-611 - PubMed
  51. New Microbiol. 2015 Jul;38(3):393-407 - PubMed
  52. Periodontol 2000. 2020 Oct;84(1):202-214 - PubMed
  53. J Clin Periodontol. 2000 Dec;27(12):910-7 - PubMed
  54. J Int Acad Periodontol. 2010 Jan;12(1):20-6 - PubMed
  55. J Evid Based Dent Pract. 2014 Jun;14 Suppl:33-41.e1 - PubMed
  56. J Periodontol. 2008 Sep;79(9):1638-44 - PubMed
  57. J Clin Periodontol. 2014 Jun;41(6):573-81 - PubMed
  58. Clin Oral Investig. 2016 Jan;20(1):141-50 - PubMed
  59. Stat Med. 2009 Dec 10;28(28):3470-82 - PubMed
  60. J Indian Soc Periodontol. 2013 Jul;17(4):439-43 - PubMed
  61. J Int Acad Periodontol. 2002 Jul;4(3):72-6 - PubMed
  62. Periodontol 2000. 2012 Jun;59(1):75-88 - PubMed
  63. BMC Med Res Methodol. 2015 Jul 31;15:58 - PubMed
  64. J Periodontol. 2001 Nov;72(11):1535-44 - PubMed
  65. J Am Dent Assoc. 2015 Jul;146(7):508-24.e5 - PubMed
  66. J Clin Periodontol. 2020 Jul;47 Suppl 22:239-256 - PubMed
  67. J Clin Epidemiol. 2018 Jan;93:36-44 - PubMed
  68. J Periodontol. 2007 Aug;78(8):1538-44 - PubMed
  69. J Periodontol. 2013 Mar;84(3):278-86 - PubMed
  70. Lancet. 2020 Oct 17;396(10258):1204-1222 - PubMed
  71. Periodontol 2000. 1996 Feb;10:139-59 - PubMed
  72. Lasers Med Sci. 2012 Jul;27(4):687-93 - PubMed
  73. Int J Dent. 2018 Apr 5;2018:1748584 - PubMed
  74. BMJ. 2003 Sep 6;327(7414):557-60 - PubMed

Publication Types

Grant support