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Subramanian K, Utriainen D, Ramasamy DP, et al. Longitudinal Magnetic Resonance Imaging of Cerebral Microbleeds in Multiple Sclerosis Patients. Diagnostics (Basel). 2020;10(11)doi: 10.3390/diagnostics10110942.
Subramanian, K., Utriainen, D., Ramasamy, D. P., Sethi, S. K., Schweser, F., Beaver, J., Hagemeier, J., Weinstock-Guttman, B., Rajagovindan, R., Zivadinov, R., & Haacke, E. M. (2020). Longitudinal Magnetic Resonance Imaging of Cerebral Microbleeds in Multiple Sclerosis Patients. Diagnostics (Basel, Switzerland), 10(11), . https://doi.org/10.3390/diagnostics10110942
Subramanian, Karthikeyan, et al. "Longitudinal Magnetic Resonance Imaging of Cerebral Microbleeds in Multiple Sclerosis Patients." Diagnostics (Basel, Switzerland) vol. 10,11 (2020). doi: https://doi.org/10.3390/diagnostics10110942
Subramanian K, Utriainen D, Ramasamy DP, Sethi SK, Schweser F, Beaver J, Hagemeier J, Weinstock-Guttman B, Rajagovindan R, Zivadinov R, Haacke EM. Longitudinal Magnetic Resonance Imaging of Cerebral Microbleeds in Multiple Sclerosis Patients. Diagnostics (Basel). 2020 Nov 12;10(11). doi: 10.3390/diagnostics10110942. PMID: 33198313; PMCID: PMC7697968.
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Diagnostics (Basel). 2020 Nov 12;10(11). doi: 10.3390/diagnostics10110942.

Longitudinal Magnetic Resonance Imaging of Cerebral Microbleeds in Multiple Sclerosis Patients.

Diagnostics (Basel, Switzerland)

Karthikeyan Subramanian, David Utriainen, Deepa P Ramasamy, Sean K Sethi, Ferdinand Schweser, John Beaver, Jesper Hagemeier, Bianca Weinstock-Guttman, Rajasimhan Rajagovindan, Robert Zivadinov, Ewart Mark Haacke

Affiliations

  1. Department of Radiology, Wayne State University, Detroit, MI 48201, USA.
  2. Magnetic Resonance Innovations, Inc., Bingham Farms, MI 48025, USA.
  3. SpinTech, Inc., Bingham Farms, MI 48025, USA.
  4. Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14203, USA.
  5. Translational Imaging Center at Clinical and Translational Science Institute, University at Buffalo, The State University of New York, Buffalo, NY 14203, USA.
  6. Translational Imaging, Abbvie Inc., North Chicago, IL 60085, USA.
  7. Jacobs Multiple Sclerosis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14202, USA.

PMID: 33198313 PMCID: PMC7697968 DOI: 10.3390/diagnostics10110942

Abstract

We hypothesized that cerebral microbleeds (CMBs) in multiple sclerosis (MS) patients will be detected with higher prevalence compared to healthy controls (HC) and that quantitative susceptibility mapping (QSM) will help remove false positives seen in susceptibility weighted imaging (SWI). A cohort of 100 relapsing remitting MS subjects scanned at 3T were used to validate a set of CMB detection guidelines specifically using QSM. A second longitudinal cohort of 112 MS and 25 HCs, also acquired at 3T, was reviewed across two time points. Both cohorts were imaged with SWI and fluid attenuated inversion recovery. Fourteen subjects in the first cohort (14%, 95% CI 8-21%) and twenty-one subjects in the second cohort (18.7%, 95% CI 11-27%) had at least one CMB. The combined information from SWI and QSM allowed us to discern stable CMBs and new CMBs from potential mimics and evaluate changes over time. The longitudinal results demonstrated that longer disease duration increased the chance to develop new CMBs. Higher age was also associated with increased CMB prevalence for MS and HC. We observed that MS subjects developed new CMBs between time points, indicating the need for longitudinal quantitative imaging of CMBs.

Keywords: cerebral microbleeds; multiple sclerosis; susceptibility mapping; susceptibility weighted imaging

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