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Hanmin C, Xiangyue Z, Lenahan C, et al. Pleiotropic Role of Tenascin-C in Central Nervous System Diseases: From Basic to Clinical Applications. Front Neurol. 2020;11:576230doi: 10.3389/fneur.2020.576230.
Hanmin, C., Xiangyue, Z., Lenahan, C., Ling, W., Yibo, O., & Yue, H. (2020). Pleiotropic Role of Tenascin-C in Central Nervous System Diseases: From Basic to Clinical Applications. Frontiers in neurology, 11576230. https://doi.org/10.3389/fneur.2020.576230
Hanmin, Chen, et al. "Pleiotropic Role of Tenascin-C in Central Nervous System Diseases: From Basic to Clinical Applications." Frontiers in neurology vol. 11 (2020): 576230. doi: https://doi.org/10.3389/fneur.2020.576230
Hanmin C, Xiangyue Z, Lenahan C, Ling W, Yibo O, Yue H. Pleiotropic Role of Tenascin-C in Central Nervous System Diseases: From Basic to Clinical Applications. Front Neurol. 2020 Nov 13;11:576230. doi: 10.3389/fneur.2020.576230. eCollection 2020. PMID: 33281711; PMCID: PMC7691598.
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Front Neurol. 2020 Nov 13;11:576230. doi: 10.3389/fneur.2020.576230. eCollection 2020.

Pleiotropic Role of Tenascin-C in Central Nervous System Diseases: From Basic to Clinical Applications.

Frontiers in neurology

Chen Hanmin, Zhou Xiangyue, Cameron Lenahan, Wang Ling, Ou Yibo, He Yue

Affiliations

  1. Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  2. Burrell College of Osteopathic Medicine, Las Cruces, NM, United States.
  3. Department of Operating Room, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

PMID: 33281711 PMCID: PMC7691598 DOI: 10.3389/fneur.2020.576230

Abstract

The extracellular matrix is composed of a variety of macromolecular substances secreted by cells, which form a complex network that supports and connects tissue structures, regulates the morphogenesis of tissues, and maintains the physiological activities of cells. Tenascin-C, a secreted extracellular matrix glycoprotein, is abundantly expressed after exposure to pathological stimuli. It plays an important regulatory role in brain tumors, vascular diseases, and neurodegenerative diseases by mediating inflammatory responses, inducing brain damage, and promoting cell proliferation, migration, and angiogenesis through multiple signaling pathways. Therefore, tenascin-C may become a potential therapeutic target for intracranial diseases. Here, we review and discuss the latest literature regarding tenascin-C, and we comprehensively explain the role and clinical significance of tenascin-C in intracranial diseases.

Copyright © 2020 Hanmin, Xiangyue, Lenahan, Ling, Yibo and Yue.

Keywords: brain injury; inflammatory; intracranial tumor; neurodegenerative diseases; tenascin-C; therapeutic target; vascular diseases

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