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Am J Hypertens. 2021 May 22;34(5):494-503. doi: 10.1093/ajh/hpaa189.

Twenty-Five-Year Changes in Office and Ambulatory Blood Pressure: Results From the Coronary Artery Risk Development in Young Adults (CARDIA) Study.

American journal of hypertension

Joshua D Bundy, Byron C Jaeger, Mark D Huffman, Sarah S Knox, S Justin Thomas, Daichi Shimbo, John N Booth, Cora E Lewis, Lloyd J Edwards, Joseph E Schwartz, Paul Muntner

Affiliations

  1. Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
  2. Tulane University Translational Science Institute, New Orleans, Louisiana, USA.
  3. Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  4. Department of Preventive Medicine and Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  5. Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  6. The George Institute for Global Health, University of New South Wales, Sydney, Australia.
  7. Department of Epidemiology, West Virginia University School of Public Health, Morgantown, West Virginia, USA.
  8. Department of Psychiatry, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA.
  9. Department of Medicine, Columbia University Medical Center, New York, New York, USA.
  10. Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  11. CTI Clinical Trials and Consulting Services, Inc., Covington, Kentucky, USA.
  12. Department of Psychiatry, Stony Brook University, New York, New York, USA.

PMID: 33201230 PMCID: PMC8140654 DOI: 10.1093/ajh/hpaa189

Abstract

BACKGROUND: Blood pressure (BP) measured in the office setting increases from early through later adulthood. However, it is unknown to what extent out-of-office BP derived via ambulatory BP monitoring (ABPM) increases over time, and which participant characteristics and risk factors might contribute to these increases.

METHODS: We assessed 25-year change in office- and ABPM-derived BP across sex, race, diabetes mellitus (DM), and body mass index (BMI) subgroups in the Coronary Artery Risk Development in Young Adults study using multivariable-adjusted linear mixed effects models.

RESULTS: We included 288 participants who underwent ABPM at the Year 5 Exam (mean [SD] age, 25.1 [3.7]; 45.8% men) and 455 participants who underwent ABPM at the Year 30 Exam (mean [SD] age, 49.5 [3.7]; 42.0% men). Office, daytime, and nighttime systolic BP (SBP) increased 12.8 (95% confidence interval [CI], 7.6-17.9), 14.7 (95% CI, 9.7-19.8), and 16.6 (95% CI, 11.4-21.8) mm Hg, respectively, over 25 years. Office SBP increased 6.5 (95% CI, 2.3-10.6) mm Hg more among black compared with white participants. Daytime SBP increased 6.3 (95% CI, 0.2-12.4) mm Hg more among participants with a BMI ≥25 vs. <25 kg/m2. Nighttime SBP increased 4.7 (95% CI, 0.5-8.9) mm Hg more among black compared with white participants, and 17.3 (95% CI, 7.2-27.4) mm Hg more among participants with vs. without DM.

CONCLUSIONS: Office- and ABPM-derived BP increased more from early through middle adulthood among black adults and participants with DM and BMI ≥25 kg/m2.

© American Journal of Hypertension, Ltd 2020. All rights reserved. For Permissions, please email: [email protected].

Keywords: aging; ambulatory blood pressure monitoring; blood pressure; epidemiology; health status disparities; hypertension; risk factors

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