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Tarawneh R. Biomarkers: Our Path Towards a Cure for Alzheimer Disease. Biomark Insights. 2020;15:1177271920976367doi: 10.1177/1177271920976367.
Tarawneh, R. (2020). Biomarkers: Our Path Towards a Cure for Alzheimer Disease. Biomarker insights, 151177271920976367. https://doi.org/10.1177/1177271920976367
Tarawneh, Rawan. "Biomarkers: Our Path Towards a Cure for Alzheimer Disease." Biomarker insights vol. 15 (2020): 1177271920976367. doi: https://doi.org/10.1177/1177271920976367
Tarawneh R. Biomarkers: Our Path Towards a Cure for Alzheimer Disease. Biomark Insights. 2020 Nov 25;15:1177271920976367. doi: 10.1177/1177271920976367. eCollection 2020. PMID: 33293784; PMCID: PMC7705771.
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Biomark Insights. 2020 Nov 25;15:1177271920976367. doi: 10.1177/1177271920976367. eCollection 2020.

Biomarkers: Our Path Towards a Cure for Alzheimer Disease.

Biomarker insights

Rawan Tarawneh

Affiliations

  1. Department of Neurology, The Ohio State University, Columbus, OH, USA.

PMID: 33293784 PMCID: PMC7705771 DOI: 10.1177/1177271920976367

Abstract

Over the last decade, biomarkers have significantly improved our understanding of the pathophysiology of Alzheimer disease (AD) and provided valuable tools to examine different disease mechanisms and their progression over time. While several markers of amyloid, tau, neuronal, synaptic, and axonal injury, inflammation, and immune dysregulation in AD have been identified, there is a relative paucity of biomarkers which reflect other disease mechanisms such as oxidative stress, mitochondrial injury, vascular or endothelial injury, and calcium-mediated excitotoxicity. Importantly, there is an urgent need to standardize methods for biomarker assessments across different centers, and to identify dynamic biomarkers which can monitor disease progression over time and/or response to potential disease-modifying treatments. The updated research framework for AD, proposed by the National Institute of Aging- Alzheimer's Association (NIA-AA) Work Group, emphasizes the importance of incorporating biomarkers in AD research and defines AD as a biological construct consisting of amyloid, tau, and neurodegeneration which spans pre-symptomatic and symptomatic stages. As results of clinical trials of AD therapeutics have been disappointing, it has become increasingly clear that the success of future AD trials will require the incorporation of biomarkers in participant selection, prognostication, monitoring disease progression, and assessing response to treatments. We here review the current state of fluid AD biomarkers, and discuss the advantages and limitations of the updated NIA-AA research framework. Importantly, the integration of biomarker data with clinical, cognitive, and imaging domains through a systems biology approach will be essential to adequately capture the molecular, genetic, and pathological heterogeneity of AD and its spatiotemporal evolution over time.

© The Author(s) 2020.

Keywords: Alzheimer disease; biomarker; inflammation; neuron; synapse

Conflict of interest statement

Declaration of conflicting interests:The author declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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