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Bohns FR, Leitune VCB, Garcia IM, et al. Incorporation of amoxicillin-loaded microspheres in mineral trioxide aggregate cement: an . Restor Dent Endod. 2020;45(4):e50doi: 10.5395/rde.2020.45.e50.
Bohns, F. R., Leitune, V. C. B., Garcia, I. M., Genari, B., Dornelles, N. B., Guterres, S. S., Ogliari, F. A., de Melo, M. A. S., & Collares, F. M. (2020). Incorporation of amoxicillin-loaded microspheres in mineral trioxide aggregate cement: an . Restorative dentistry & endodontics, 45(4), e50. https://doi.org/10.5395/rde.2020.45.e50
Bohns, Fábio Rocha, et al. "Incorporation of amoxicillin-loaded microspheres in mineral trioxide aggregate cement: an ." Restorative dentistry & endodontics vol. 45,4 (2020): e50. doi: https://doi.org/10.5395/rde.2020.45.e50
Bohns FR, Leitune VCB, Garcia IM, Genari B, Dornelles NB, Guterres SS, Ogliari FA, de Melo MAS, Collares FM. Incorporation of amoxicillin-loaded microspheres in mineral trioxide aggregate cement: an . Restor Dent Endod. 2020 Oct 07;45(4):e50. doi: 10.5395/rde.2020.45.e50. eCollection 2020 Nov. PMID: 33294415; PMCID: PMC7691264.
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Restor Dent Endod. 2020 Oct 07;45(4):e50. doi: 10.5395/rde.2020.45.e50. eCollection 2020 Nov.

Incorporation of amoxicillin-loaded microspheres in mineral trioxide aggregate cement: an .

Restorative dentistry & endodontics

Fábio Rocha Bohns, Vicente Castelo Branco Leitune, Isadora Martini Garcia, Bruna Genari, Nélio Bairros Dornelles, Silvia Stanisçuaski Guterres, Fabrício Aulo Ogliari, Mary Anne Sampaio de Melo, Fabrício Mezzomo Collares

Affiliations

  1. Department of Dental Materials, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
  2. Department of Orthodontics and Biomaterials, Centro Universitário UDF, Brasília, DF, Brazil.
  3. Cosmetology Laboratory, School of Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
  4. Yller Biomaterials, Pelotas, RS, Brazil.
  5. Program in Biomedical Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA.
  6. Division of Operative Dentistry, Department of General Dentistry, University of Maryland School of Dentistry, Baltimore, MD, USA.

PMID: 33294415 PMCID: PMC7691264 DOI: 10.5395/rde.2020.45.e50

Abstract

OBJECTIVES: In this study, we investigated the potential of amoxicillin-loaded polymeric microspheres to be delivered to tooth root infection sites via a bioactive reparative cement.

MATERIALS AND METHODS: Amoxicillin-loaded microspheres were synthesized by a spray-dray method and incorporated at 2.5% and 5% into a mineral trioxide aggregate cement clinically used to induce a mineralized barrier at the root tip of young permanent teeth with incomplete root development and necrotic pulp. The formulations were modified in liquid:powder ratios and in composition by the microspheres. The optimized formulations were evaluated

RESULTS: The optimized cement formulation containing microspheres at 5% exhibited a delayed-release response and maintained its fundamental functional properties. When mixed with amoxicillin-loaded microspheres, the setting times of both test materials significantly increased. The diametral tensile strength of cement containing microspheres at 5% was similar to control. However, phytic acid had no effect on this outcome (

CONCLUSIONS: Lack of optimal concentrations of antibiotics at anatomical sites of the dental tissues is a hallmark of recurrent endodontic infections. Therefore, targeting the controlled release of broad-spectrum antibiotics may improve the therapeutic outcomes of current treatments. Overall, these results indicate that the carry of amoxicillin by microspheres could provide an alternative strategy for the local delivery of antibiotics for the management of tooth infections.

Copyright © 2020. The Korean Academy of Conservative Dentistry.

Keywords: Aggregate trioxide mineral; Amoxicillin; Dental materials; Endodontics; Microspheres

Conflict of interest statement

Conflict of Interest: No potential conflict of interest relevant to this article was reported.

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