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Ward A, Brown B, Walton K, et al. Application of Focus Variation Microscopy and Dissolution Imaging in Understanding the Behaviour of Hydrophilic Matrices. Pharmaceutics. 2020;12(12)doi: 10.3390/pharmaceutics12121162.
Ward, A., Brown, B., Walton, K., Timmins, P., Conway, B. R., & Asare-Addo, K. (2020). Application of Focus Variation Microscopy and Dissolution Imaging in Understanding the Behaviour of Hydrophilic Matrices. Pharmaceutics, 12(12), . https://doi.org/10.3390/pharmaceutics12121162
Ward, Adam, et al. "Application of Focus Variation Microscopy and Dissolution Imaging in Understanding the Behaviour of Hydrophilic Matrices." Pharmaceutics vol. 12,12 (2020). doi: https://doi.org/10.3390/pharmaceutics12121162
Ward A, Brown B, Walton K, Timmins P, Conway BR, Asare-Addo K. Application of Focus Variation Microscopy and Dissolution Imaging in Understanding the Behaviour of Hydrophilic Matrices. Pharmaceutics. 2020 Nov 28;12(12). doi: 10.3390/pharmaceutics12121162. PMID: 33260657; PMCID: PMC7759878.
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Pharmaceutics. 2020 Nov 28;12(12). doi: 10.3390/pharmaceutics12121162.

Application of Focus Variation Microscopy and Dissolution Imaging in Understanding the Behaviour of Hydrophilic Matrices.

Pharmaceutics

Adam Ward, Benedict Brown, Karl Walton, Peter Timmins, Barbara R Conway, Kofi Asare-Addo

Affiliations

  1. Department of Pharmacy, University of Huddersfield, Huddersfield HD1 3DH, UK.
  2. EPSRC Future Metrology Hub, University of Huddersfield, Huddersfield HD1 3DH, UK.

PMID: 33260657 PMCID: PMC7759878 DOI: 10.3390/pharmaceutics12121162

Abstract

Hydrophilic matrix systems can be found in a wide range of extended release pharmaceutical formulations. The main principle of these systems is that upon contact with water, the hydrophilic component swells to form a hydrated gel layer which controls drug release. The following work demonstrates an explorative study into the use of dissolution imaging and focus variation microscopy with hydrophilic polymers. This study investigated the surface properties of xanthan gum (XG), polyethylene oxide (PEO), and hypromellose (hydroxypropyl methylcellulose, HPMC) compacts with each of these three hydrophilic polymers from one of each classification of natural, semi-synthetic, or synthetic polymer using a focus variation instrument. The auto correlation length (S

Keywords: focus variation; hypromellose; polyethylene oxide; surface dissolution imaging; swelling; xanthan gum

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