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Fuster DG, Morard GA, Schneider L, et al. Association of urinary sex steroid hormones with urinary calcium, oxalate and citrate excretion in kidney stone formers. Nephrol Dial Transplant. 2020;doi: 10.1093/ndt/gfaa360.
Fuster, D. G., Morard, G. A., Schneider, L., Mattmann, C., Lüthi, D., Vogt, B., & Dhayat, N. A. (2020). Association of urinary sex steroid hormones with urinary calcium, oxalate and citrate excretion in kidney stone formers. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, . https://doi.org/10.1093/ndt/gfaa360
Fuster, Daniel G, et al. "Association of urinary sex steroid hormones with urinary calcium, oxalate and citrate excretion in kidney stone formers." Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association vol. (2020). doi: https://doi.org/10.1093/ndt/gfaa360
Fuster DG, Morard GA, Schneider L, Mattmann C, Lüthi D, Vogt B, Dhayat NA. Association of urinary sex steroid hormones with urinary calcium, oxalate and citrate excretion in kidney stone formers. Nephrol Dial Transplant. 2020 Dec 09; doi: 10.1093/ndt/gfaa360. Epub 2020 Dec 09. PMID: 33295624.
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Nephrol Dial Transplant. 2020 Dec 09; doi: 10.1093/ndt/gfaa360. Epub 2020 Dec 09.

Association of urinary sex steroid hormones with urinary calcium, oxalate and citrate excretion in kidney stone formers.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Daniel G Fuster, Gaétan A Morard, Lisa Schneider, Cedric Mattmann, David Lüthi, Bruno Vogt, Nasser A Dhayat

Affiliations

  1. Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

PMID: 33295624 DOI: 10.1093/ndt/gfaa360

Abstract

BACKGROUND: Sex-specific differences in nephrolithiasis with respect to both distribution of prevalence and stone composition are widely described and may be influenced by sex hormones.

METHODS: We conducted a cross-sectional analysis of the relationship between 24-hour urinary sex hormone metabolites measured by gas chromatography-mass spectrometry with urinary calcium, oxalate and citrate excretion in a cohort of 628 kidney stone formers from a tertiary care hospital in Switzerland, taking demographic characteristics, kidney function and dietary factors into account.

RESULTS: We observed a positive association of urinary calcium with urinary testosterone and 17β-estradiol. Positive associations of urinary calcium with dehydroepiandrosterone, 5α-DH-testosterone, etiocholanolone, androsterone, and estriol were modified by net gastrointestinal alkali absorption or urinary sulfate excretion. As the only sex hormone, dehydroepiandrosterone was inversely associated with urinary oxalate excretion in adjusted analyses. Urinary citrate correlated positively with urinary testosterone. Associations of urinary citrate with urinary androsterone, 17β-estradiol and estriol were modified by urinary sulfate or sodium, or by sex.

CONCLUSIONS: Urinary androgens and estrogens are significantly associated with urinary calcium and citrate excretion, and associations are in part modified by diet. Our data furthermore reveal dehydroepiandrosterone as a novel factor associated with urinary oxalate excretion in humans.

© The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

Keywords: dietary factors; lithogenic risk factors; nephrolithiasis; sex steroid hormones

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