Display options
Cite
Olby NJ, da Costa RC, Levine JM, et al. Prognostic Factors in Canine Acute Intervertebral Disc Disease. Front Vet Sci. 2020;7:596059doi: 10.3389/fvets.2020.596059.
Olby, N. J., da Costa, R. C., Levine, J. M., Stein, V. M. (2020). Prognostic Factors in Canine Acute Intervertebral Disc Disease. Frontiers in veterinary science, 7596059. https://doi.org/10.3389/fvets.2020.596059
Olby, Natasha J, et al. "Prognostic Factors in Canine Acute Intervertebral Disc Disease." Frontiers in veterinary science vol. 7 (2020): 596059. doi: https://doi.org/10.3389/fvets.2020.596059
Olby NJ, da Costa RC, Levine JM, Stein VM. Prognostic Factors in Canine Acute Intervertebral Disc Disease. Front Vet Sci. 2020 Nov 26;7:596059. doi: 10.3389/fvets.2020.596059. eCollection 2020. PMID: 33324703; PMCID: PMC7725764.
Copy Download .nbib Format: NLM
Share it on

Front Vet Sci. 2020 Nov 26;7:596059. doi: 10.3389/fvets.2020.596059. eCollection 2020.

Prognostic Factors in Canine Acute Intervertebral Disc Disease.

Frontiers in veterinary science

Natasha J Olby, Ronaldo C da Costa, Jon M Levine, Veronika M Stein,

Affiliations

  1. Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, United States.
  2. Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, United States.
  3. Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, United States.
  4. Department for Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

PMID: 33324703 PMCID: PMC7725764 DOI: 10.3389/fvets.2020.596059

Abstract

Knowledge of the prognosis of acute spinal cord injury is critical to provide appropriate information for clients and make the best treatment choices. Acute intervertebral disc extrusions (IVDE) are a common cause of pain and paralysis in dogs with several types of IVDE occurring. Important prognostic considerations are recovery of ambulation, return of urinary and fecal continence, resolution of pain and, on the negative side, development of progressive myelomalacia. Initial injury severity affects prognosis as does type of IVDE, particularly when considering recovery of continence. Overall, loss of deep pain perception signals a worse outcome. When considering Hansen type 1 IVDE, the prognosis is altered by the choice of surgical vs. medical therapy. Concentration of structural proteins in the plasma, as well as inflammatory mediators, creatine kinase, and myelin basic protein in the cerebrospinal fluid (CSF) can provide additional prognostic information. Finally, cross-sectional area and length of T2 hyperintensity and loss of HASTE signal on MRI have been associated with outcome. Future developments in plasma and imaging biomarkers will assist in accurate prognostication and optimization of patient management.

Copyright © 2020 Olby, da Costa, Levine, Stein and the Canine Spinal Cord Injury Consortium (CANSORT SCI).

Keywords: acute intervertebral disc extrusion; acute non-compressive nucleus pulposus extrusion; ambulation; dog; pain perception; paraplegia; spinal cord injury

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

  1. J Am Vet Med Assoc. 1968 Dec 1;153(11):1412-7 - PubMed
  2. J Am Anim Hosp Assoc. 2009 Jul-Aug;45(4):155-63 - PubMed
  3. J Vet Intern Med. 2018 May;32(3):1116-1125 - PubMed
  4. Vet Surg. 2012 Feb;41(2):200-6 - PubMed
  5. Mol Oncol. 2008 Apr;1(4):406-12 - PubMed
  6. Vet Surg. 2007 Jul;36(5):492-9 - PubMed
  7. J Small Anim Pract. 2020 Jul;61(7):442-448 - PubMed
  8. Vet Surg. 2013 Oct;42(7):795-806 - PubMed
  9. J Vet Intern Med. 2017 Nov;31(6):1782-1789 - PubMed
  10. J Am Vet Med Assoc. 2009 Feb 15;234(4):495-504 - PubMed
  11. J Am Vet Med Assoc. 2008 Jul 1;233(1):129-35 - PubMed
  12. J Am Vet Med Assoc. 2016 Feb 15;248(4):405-12 - PubMed
  13. J Vet Med Sci. 2013 Jul 31;75(7):949-53 - PubMed
  14. Am J Vet Res. 2006 Feb;67(2):283-7 - PubMed
  15. Vet J. 2013 Aug;197(2):253-8 - PubMed
  16. J Neurotrauma. 2012 Mar 20;29(5):1000-11 - PubMed
  17. J Vet Intern Med. 2010 Jul-Aug;24(4):890-6 - PubMed
  18. J Am Vet Med Assoc. 2012 Dec 15;241(12):1617-26 - PubMed
  19. Am J Vet Res. 1988 Jul;49(7):1143-6 - PubMed
  20. Spine J. 2020 Feb;20(2):213-224 - PubMed
  21. J Am Vet Med Assoc. 2006 Mar 15;228(6):902-8 - PubMed
  22. J Neurotrauma. 2018 Feb 1;35(3):500-507 - PubMed
  23. Vet Rec. 2020 Nov 14;187(10):e81 - PubMed
  24. Vet Surg. 2002 Nov-Dec;31(6):513-8 - PubMed
  25. Vet Radiol Ultrasound. 2002 Jul-Aug;43(4):326-30 - PubMed
  26. J Vet Intern Med. 2019 Nov;33(6):2693-2700 - PubMed
  27. Vet Surg. 2007 Jul;36(5):482-91 - PubMed
  28. Berl Munch Tierarztl Wochenschr. 2008 Mar-Apr;121(3-4):159-70 - PubMed
  29. Vet Comp Orthop Traumatol. 2006;19(1):29-34 - PubMed
  30. BMC Vet Res. 2019 Dec 3;15(1):433 - PubMed
  31. Vet Rec. 2017 Dec;181(22):594-599 - PubMed
  32. J Neurotrauma. 2020 Nov 1;37(21):2261-2267 - PubMed
  33. Magn Reson Med. 1994 Oct;32(4):484-91 - PubMed
  34. J Neurotrauma. 2020 Dec 4;: - PubMed
  35. J Neurotrauma. 2017 Nov 1;34(21):2994-3002 - PubMed
  36. J Am Vet Med Assoc. 2005 Nov 1;227(9):1454-60 - PubMed
  37. J Neurotrauma. 2018 Aug 1;35(15):1726-1736 - PubMed
  38. Spinal Cord. 2007 Mar;45(3):190-205 - PubMed
  39. Vet Rec. 2010 Apr 24;166(17):523-8 - PubMed
  40. Vet Rec. 2017 Sep 16;181(11):293 - PubMed
  41. J Am Vet Med Assoc. 2001 May 15;218(10):1598-602 - PubMed
  42. AJNR Am J Neuroradiol. 1999 May;20(5):926-34 - PubMed
  43. J Vet Intern Med. 2017 Mar;31(2):492-497 - PubMed
  44. J Vet Intern Med. 2005 Nov-Dec;19(6):788-93 - PubMed
  45. J Vet Intern Med. 2019 Mar;33(2):726-734 - PubMed
  46. J Am Vet Med Assoc. 2003 Mar 15;222(6):762-9 - PubMed
  47. J Vet Intern Med. 2018 Nov;32(6):1989-1995 - PubMed
  48. Vet Surg. 1993 Jan-Feb;22(1):5-10 - PubMed
  49. Vet J. 2016 Nov;217:40-42 - PubMed
  50. Vet J. 2015 Mar;203(3):342-4 - PubMed
  51. AJNR Am J Neuroradiol. 1990 Sep-Oct;11(5):959-65 - PubMed
  52. Vet Clin North Am Small Anim Pract. 2014 Nov;44(6):1131-56 - PubMed
  53. Vet Rec. 2016 Dec 24;179(25):650 - PubMed
  54. Vet Rec. 2017 Dec;181(23):625 - PubMed
  55. J Spinal Disord Tech. 2012 May;25(3):E81-7 - PubMed
  56. Vet Radiol Ultrasound. 2017 Mar;58(2):197-205 - PubMed
  57. Vet Surg. 2014 Mar;43(3):301-7 - PubMed
  58. J Small Anim Pract. 2003 Feb;44(2):76-80 - PubMed
  59. J Am Vet Med Assoc. 2010 Nov 15;237(10):1160-5 - PubMed
  60. J Vet Intern Med. 2017 Mar;31(2):498-504 - PubMed
  61. Vet J. 2017 Mar;221:48-53 - PubMed
  62. Vet Anaesth Analg. 2014 Mar;41(2):137-44 - PubMed
  63. J Am Anim Hosp Assoc. 2004 Jul-Aug;40(4):316-20 - PubMed
  64. J Am Anim Hosp Assoc. 2003 Nov-Dec;39(6):513-7 - PubMed
  65. J Vet Intern Med. 2017 May;31(3):825-831 - PubMed
  66. Vet Surg. 1996 Jan-Feb;25(1):6-12 - PubMed
  67. J Vet Intern Med. 2017 May;31(3):842-848 - PubMed
  68. J Vet Intern Med. 2011 Jul-Aug;25(4):846-55 - PubMed
  69. J Am Anim Hosp Assoc. 2001 Jul-Aug;37(4):374-83 - PubMed
  70. J Small Anim Pract. 2002 Apr;43(4):158-63 - PubMed
  71. Vet Clin North Am Small Anim Pract. 1992 Jul;22(4):833-57 - PubMed
  72. Am J Vet Res. 1987 Oct;48(10):1525-30 - PubMed
  73. J Vet Emerg Crit Care (San Antonio). 2016 May;26(3):412-8 - PubMed
  74. J Am Vet Med Assoc. 2012 Mar 1;240(5):555-62 - PubMed
  75. J Small Anim Pract. 2016 Aug;57(8):409-15 - PubMed
  76. J Small Anim Pract. 1999 Sep;40(9):417-22 - PubMed
  77. Vet Surg. 2017 Apr;46(3):376-380 - PubMed
  78. J Transl Med. 2018 Sep 17;16(1):258 - PubMed
  79. Vet J. 2017 Feb;220:7-16 - PubMed
  80. Am J Vet Res. 1993 Nov;54(11):1935-41 - PubMed
  81. Vet Surg. 2014 Mar;43(3):289-93 - PubMed
  82. J Small Anim Pract. 2002 Oct;43(10):439-46 - PubMed
  83. Acta Vet Scand. 2015 Sep 25;57:58 - PubMed
  84. Am J Vet Res. 2011 Jul;72(7):893-8 - PubMed
  85. J Vet Intern Med. 2009 Nov-Dec;23(6):1220-6 - PubMed
  86. Am J Vet Res. 1998 Mar;59(3):300-6 - PubMed
  87. J Am Vet Med Assoc. 2016 Oct 1;249(7):767-75 - PubMed
  88. Am J Vet Res. 1979 Mar;40(3):326-33 - PubMed
  89. J Small Anim Pract. 2012 Feb;53(2):101-7 - PubMed
  90. J Neurotrauma. 2004 Jan;21(1):49-59 - PubMed
  91. J Neurotrauma. 2014 Sep 15;31(18):1561-9 - PubMed
  92. Vet J. 2018 Jul;237:49-54 - PubMed
  93. J Am Vet Med Assoc. 2016 Feb 15;248(4):386-94 - PubMed

Publication Types