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Kenes MT, McSparron JI, Marshall VD, et al. Propofol-Associated Hypertriglyceridemia in Coronavirus Disease 2019 Versus Noncoronavirus Disease 2019 Acute Respiratory Distress Syndrome. Crit Care Explor. 2020;2(12):e0303doi: 10.1097/CCE.0000000000000303.
Kenes, M. T., McSparron, J. I., Marshall, V. D., Renius, K., & Hyzy, R. C. (2020). Propofol-Associated Hypertriglyceridemia in Coronavirus Disease 2019 Versus Noncoronavirus Disease 2019 Acute Respiratory Distress Syndrome. Critical care explorations, 2(12), e0303. https://doi.org/10.1097/CCE.0000000000000303
Kenes, Michael T, et al. "Propofol-Associated Hypertriglyceridemia in Coronavirus Disease 2019 Versus Noncoronavirus Disease 2019 Acute Respiratory Distress Syndrome." Critical care explorations vol. 2,12 (2020): e0303. doi: https://doi.org/10.1097/CCE.0000000000000303
Kenes MT, McSparron JI, Marshall VD, Renius K, Hyzy RC. Propofol-Associated Hypertriglyceridemia in Coronavirus Disease 2019 Versus Noncoronavirus Disease 2019 Acute Respiratory Distress Syndrome. Crit Care Explor. 2020 Dec 16;2(12):e0303. doi: 10.1097/CCE.0000000000000303. eCollection 2020 Dec. PMID: 33354676; PMCID: PMC7746206.
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Crit Care Explor. 2020 Dec 16;2(12):e0303. doi: 10.1097/CCE.0000000000000303. eCollection 2020 Dec.

Propofol-Associated Hypertriglyceridemia in Coronavirus Disease 2019 Versus Noncoronavirus Disease 2019 Acute Respiratory Distress Syndrome.

Critical care explorations

Michael T Kenes, Jakob I McSparron, Vincent D Marshall, Karl Renius, Robert C Hyzy

Affiliations

  1. Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, MI.
  2. Department of Pharmacy, Michigan Medicine, University of Michigan, Ann Arbor, MI.
  3. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.

PMID: 33354676 PMCID: PMC7746206 DOI: 10.1097/CCE.0000000000000303

Abstract

OBJECTIVES: To characterize the incidence and characteristics of propofol-associated hypertriglyceridemia in coronavirus disease 2019 versus noncoronavirus disease 2019 acute respiratory distress syndrome.

DESIGN: Single-center prospective, observational cohort study.

SETTING: Medical ICU and regional infectious containment unit.

PATIENTS: Patients with acute respiratory distress syndrome admitted from April 7, 2020, to May 15, 2020, requiring continuous propofol administration.

INTERVENTIONS: None.

MEASUREMENTS AND MAIN RESULTS: Of 50 patients enrolled, 54% had coronavirus disease 2019 acute respiratory distress syndrome. Median Acute Physiology and Chronic Health Evaluation II and Sequential Organ Failure Assessment scores were 35.5 (interquartile range, 30.2-41) and 8 (interquartile range, 6-9). Pao

CONCLUSIONS: Patients with coronavirus disease 2019 acute respiratory distress syndrome experienced a higher rate of propofol-associated hypertriglyceridemia than noncoronavirus disease 2019 acute respiratory distress syndrome patients, even after accounting for differences in propofol administration.

Copyright © 2020 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine.

Keywords: coronavirus disease 2019; hypertriglyceridemia; inflammation; propofol; sedation

Conflict of interest statement

The authors have disclosed that they do not have any potential conflicts of interest.

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