Display options
Cite
Gallotti B, Galvao I, Leles G, et al. Effects of dietary fibre intake in chemotherapy-induced mucositis in murine model. Br J Nutr. 2020;126(6):853-864doi: 10.1017/S0007114520004924.
Gallotti, B., Galvao, I., Leles, G., Quintanilha, M. F., Souza, R. O., Miranda, V. C., Rocha, V. M., Trindade, L. M., Jesus, L. C. L., Mendes, V., Andre, L. C., d'Auriol-Souza, M. M., Azevedo, V., Cardoso, V. N., Martins, F. S., & Vieira, A. T. (2021). Effects of dietary fibre intake in chemotherapy-induced mucositis in murine model. The British journal of nutrition, 126(6), 853-864. https://doi.org/10.1017/S0007114520004924
Gallotti, B, et al. "Effects of dietary fibre intake in chemotherapy-induced mucositis in murine model." The British journal of nutrition vol. 126,6 (2021): 853-864. doi: https://doi.org/10.1017/S0007114520004924
Gallotti B, Galvao I, Leles G, Quintanilha MF, Souza RO, Miranda VC, Rocha VM, Trindade LM, Jesus LCL, Mendes V, Andre LC, d'Auriol-Souza MM, Azevedo V, Cardoso VN, Martins FS, Vieira AT. Effects of dietary fibre intake in chemotherapy-induced mucositis in murine model. Br J Nutr. 2021 Sep 28;126(6):853-864. doi: 10.1017/S0007114520004924. Epub 2020 Dec 10. PMID: 33298215.
Copy Download .nbib Format: NLM
Share it on

Br J Nutr. 2021 Sep 28;126(6):853-864. doi: 10.1017/S0007114520004924. Epub 2020 Dec 10.

Effects of dietary fibre intake in chemotherapy-induced mucositis in murine model.

The British journal of nutrition

B Gallotti, I Galvao, G Leles, M F Quintanilha, R O Souza, V C Miranda, V M Rocha, L M Trindade, L C L Jesus, V Mendes, L C Andre, M M d'Auriol-Souza, V Azevedo, V N Cardoso, F S Martins, A T Vieira

Affiliations

  1. Laboratório de Microbiota e Imunomodulação, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  2. Laboratório de Agentes Bioterapêuticos, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  3. Laboratório de Radioisótopos, Departamento de Analises Clinicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  4. Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Departamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  5. Laboratório de Toxicologia Ocupacional, Departamento de Analises Clinicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

PMID: 33298215 DOI: 10.1017/S0007114520004924

Abstract

Mucositis is an inflammation of the gastrointestinal mucosa resulting from high doses of radio/chemotherapy treatment and may lead to interruption of antineoplasic therapy. Soluble fibres, like pectin, increase SCFA production, which play a role in gut homoeostasis and inflammation suppression. Due to the properties of pectin, the aim of the present study was to evaluate the effect of a high-fibre (HF) diet on chemotherapy-induced mucositis in a murine model. C57/BL6 mice received control (AIN93M), HF, low/zero fibre (LF) diets for 10 d prior to mucositis challenging with irinotecan (75 mg/kg), or they were treated with acetate added to drinking water 5 d prior to and during the mucositis induction. Mice that received the HF diet showed decreased immune cells influx and improved histopathological parameters in the intestine, compared with mice that received the normal diet. Furthermore, the HF diet decreased intestinal permeability induced in the mucositis model when compared with the control group. This effect was not observed for acetate alone, which did not improve gut permeability. For instance, mice that received the LF diet had worsened gut permeability, compared with mice that received the normal diet and mucositis. The effects of the HF and LF diets were shown to modulate the intestinal microbiota, in which the LF diet increased the levels of Enterobacteriaceae, a group associated with gut inflammation, whereas the HF diet decreased this group and increased Lactobacillus and Bifidobacterium (SCFA producers) levels. In conclusion, the results demonstrated the importance of dietary fibre intake in the modulation of gut microbiota composition and homoeostasis maintenance during mucositis in this model.

Keywords: Fibre; Microbiota modulation; Mucositis; Pectin; SCFA

Publication Types